DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and LOC100331049

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_002665901.2	Gene:	LOC100331049 / 100331049	-ID:	-	Length:	301	Species:	Danio rerio

Alignment Length:	310	Identity:	156/310 - (50%)
Similarity:	225/310 - (72%)	Gaps:	19/310 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 DSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPA 179
            |..|:|    |||  .|||:.:..||||||||..:.||:||.|||.||  ..|.|:|::|.|:..
Zfish     4 DVAVHI----TRH--PFSGREVPISNGSGFIISSDDLIVTNGHVVANK--RGVCVKLTNGETYNT 60

  Fly   180 TIEDVDQTSDLATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ 243
            |::||||.:|:||::|.|.| |..:||||||.:|.||:|||:||..:|.||:|:|::|..||.|:
Zfish    61 TVQDVDQAADIATIKINVKNPLPTLRLGKSSDVRQGEFVVAMGSLFSLKNTITSGIVSFAQRGSK 125

  Fly   244 ELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEK 308
            ||||.|.:::|:||||.|.||||||||:|||||.||:|:||||||||||||.|.|::|.:|:|:|
Zfish   126 ELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISFAIPSDRVRLFFDRSADK 190

  Fly   309 RKK---GSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGG 370
            :|.   .|.:|     :||:|:.||||||.|:.||:.|..:.| :::||||:.:|||||||:..|
Zfish   191 QKSWFGESGWK-----RRYIGVMMLTLTPSIIEELRMRDPSFP-DVSHGVLIHRVIVGSPANRAG 249

  Fly   371 LQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPE 420
            ::|||::..||..::..|.::|:|:. .|::|::|:.||...:.:.:|||
Zfish   250 MKPGDVIIEINGVKVNTSEEIYNAVR-TSESLNVVVRRGADLLMLHMTPE 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	156/310 (50%)
		Trypsin_2	141..280	CDD:290102	80/139 (58%)
		PDZ_serine_protease	323..417	CDD:238487	39/93 (42%)
LOC100331049	XP_002665901.2	Trypsin_2	24..162	CDD:290102	80/139 (58%)
LOC100331049	XP_002665901.2	PDZ_serine_protease	203..287	CDD:238487	37/85 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9474
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113300
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920