DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and si:dkey-84o3.2

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_005161042.1	Gene:	si:dkey-84o3.2 / 100330919	ZFINID:	ZDB-GENE-091113-19	Length:	209	Species:	Danio rerio

Alignment Length:	179	Identity:	96/179 - (53%)
Similarity:	138/179 - (77%)	Gaps:	9/179 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMK 284
            :||..:|.||:|:|::||.||.|:||||.|.:::|:||||.|.||||||||:|||||.||:|:||
Zfish     1 MGSLFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMK 65

  Fly   285 VTAGISFAIPIDYVKVFLERAAEKRKK---GSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQN 346
            ||||||||||.|.|::||||:|:|:|.   .|.:|     :||:|:.||||||.|:.||:.|..:
Zfish    66 VTAGISFAIPSDRVRLFLERSADKQKSWFGESGWK-----RRYIGVMMLTLTPSIIEELRMRDPS 125

  Fly   347 MPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDAL 395
            .| :::||||:.:|||||||:..|::|||::..||..::..|.::|:|:
Zfish   126 FP-DVSHGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEIYNAV 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	96/179 (54%)
		Trypsin_2	141..280	CDD:290102	37/59 (63%)
		PDZ_serine_protease	323..417	CDD:238487	34/73 (47%)
si:dkey-84o3.2	XP_005161042.1	Trypsin_2	<4..61	CDD:290102	35/56 (63%)
si:dkey-84o3.2	XP_005161042.1	PDZ_serine_protease	102..>179	CDD:238487	34/73 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579615
Domainoid	1	1.000	70	1.000	Domainoid score	I9474
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113300
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740