DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and si:dkey-112g5.13

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001103205.1	Gene:	si:dkey-112g5.13 / 100003308	ZFINID:	ZDB-GENE-081028-21	Length:	200	Species:	Danio rerio

Alignment Length:	201	Identity:	102/201 - (50%)
Similarity:	152/201 - (75%)	Gaps:	4/201 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMK 284
            :|||.:|.||:|:|::||.||.|:||||.|.:::|:||||.|.||||||||.|||||.||:|:||
Zfish     1 MGSPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLTNLDGEVIGINTMK 65

  Fly   285 VTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPS 349
            ||||||||||...|::||:|:|:|:|  |.:......:||:|:.||||||.|:.||:.|..:.|
Zfish    66 VTAGISFAIPSGRVRLFLDRSADKQK--SWFGESGSKRRYIGVMMLTLTPSIIKELRMRDLSFP- 127

  Fly   350 NLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMH 414
            :::||||:.:|||||||:..|::|||::..||..::..|.::|:|:. .|::|::|:.||...:.
Zfish   128 DVSHGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEIYNAVR-TSESLNVVVRRGADLLM 191

  Fly   415 VTITPE 420
            :.:|||
Zfish   192 LHMTPE 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	102/201 (51%)
		Trypsin_2	141..280	CDD:290102	38/59 (64%)
		PDZ_serine_protease	323..417	CDD:238487	39/93 (42%)
si:dkey-112g5.13	NP_001103205.1	Trypsin_2	<1..61	CDD:290102	38/59 (64%)
si:dkey-112g5.13	NP_001103205.1	PDZ_serine_protease	102..186	CDD:238487	37/85 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579602
Domainoid	1	1.000	70	1.000	Domainoid score	I9474
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113300
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.710