DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and si:dkey-33c12.12

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001082916.2	Gene:	si:dkey-33c12.12 / 100000024	ZFINID:	ZDB-GENE-081028-30	Length:	214	Species:	Danio rerio

Alignment Length:	204	Identity:	104/204 - (50%)
Similarity:	155/204 - (75%)	Gaps:	10/204 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMK 284
            :|||.:|.||:|:|:|||.||.|:||||.|.:::|:||||.|.||||||||:|||||.||:|:||
Zfish     1 MGSPFSLKNTITSGIISSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMK 65

  Fly   285 VTAGISFAIPIDYVKVFLERAAEKRKK---GSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQN 346
            ||||||||||:..|::||:|:|:|:|.   .|.:|     :||:|:.||||||.|:.||:.|..:
Zfish    66 VTAGISFAIPLGRVRLFLDRSADKQKSWFGESGWK-----RRYIGVMMLTLTPSIIEELRMRDPS 125

  Fly   347 MPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVK 411
            .| :::||||:.:|||||||:..|::|||::..||..::..|.::|:|:. .|::|::|:.||..
Zfish   126 FP-DISHGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEIYNAVR-TSESLNVVVRRGAD 188

  Fly   412 QMHVTITPE 420
            .:.:.:|||
Zfish   189 LLMLHMTPE 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	104/204 (51%)
		Trypsin_2	141..280	CDD:290102	39/59 (66%)
		PDZ_serine_protease	323..417	CDD:238487	39/93 (42%)
si:dkey-33c12.12	NP_001082916.2	Trypsin_2	<1..61	CDD:290102	39/59 (66%)
si:dkey-33c12.12	NP_001082916.2	PDZ_serine_protease	102..186	CDD:238487	37/85 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579598
Domainoid	1	1.000	176	1.000	Domainoid score	I3556
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2456
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm25664
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760