DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MCM6 and rec

DIOPT Version :9

Sequence 1:NP_005906.2 Gene:MCM6 / 4175 HGNCID:6949 Length:821 Species:Homo sapiens
Sequence 2:NP_001262615.1 Gene:rec / 49241 FlyBaseID:FBgn0003227 Length:885 Species:Drosophila melanogaster


Alignment Length:845 Identity:195/845 - (23%)
Similarity:330/845 - (39%) Gaps:192/845 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     5 AAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFV--- 66
            ||.|.|...|.:.|.:..|....:|:  ||.|......|:....:|.|... :||.....||   
  Fly    93 AAPEDGLQVQSIAVDNPRAYSGWRLY--FLREKYEEGNELATRIMAVEAYY-QRNPHTFDFVMIR 154

Human    67 ----------------DLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK------------- 102
                            .|::....||..|:|...|....|..|:.|.|.:.:             
  Fly   155 DRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVST 219

Human   103 ------EIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDC 161
                  ..|..:..|....|......|..::.||:..|..|.|.|.........|....|.|..|
  Fly   220 PEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRC 284

Human   162 QTVIRDVEQQFKYTQPNICRNPVCANRRRF--LLDTNKSRFVDFQKVRIQETQAELPRG---SIP 221
            |..|...::.....:|..|:...|..|..|  |..:..:|....|.:|::|:...|...   |:|
  Fly   285 QMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMP 349

Human   222 RSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRA 286
            ..::|.||.:.|::.:.|.:       :||..:.||...|....|....:.:..|       |:|
  Fly   350 AEMDVELRHDLVDAVRVGQE-------VVVTGILKLQELGDDTTTGDTSNQMQPY-------LKA 400

Human   287 LGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLC 351
            :.:||                              |.|||.:.:.::.|.:..::.:.|.:..|.
  Fly   401 VSIRD------------------------------ASSIKREFSERDLEAIVMINAEPNSFKLLV 435

Human   352 TSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRA 416
            .|:.|.::|::..|...||.|.|      |:|..... |||.:||||...|::.|:...:.:.|.
  Fly   436 QSIAPEVYGHELPKAACLLSLLG------GKGAETEA-INVLLVGDPGIGKTKILQSCAQIAERG 493

Human   417 VYTSGK--ASSA--AGLTAAVVRDEESHEFVIEAGALMLAD-NGVCCIDEFDKMDVRDQVAIHEA 476
            .:.|||  |.||  .|:|.|     ..::.|::||:||:|. .|.|.:|:.||: ...|..:.:.
  Fly   494 AHVSGKRGAQSAQQLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQC 552

Human   477 MEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECN 541
            ::.:.:::..||..|:..|:.|::|.|||..|.||..:.|.||||:|..::..|.|.:||:|:.:
  Fly   553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS 617

Human   542 EVTDYAIARRIVDLHS---------------------------------------RIEESIDRV- 566
            | .|.::...:..||:                                       :.|:..|.: 
  Fly   618 E-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIM 681

Human   567 ---YSLDD------------------IRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSGV 609
               |.||.                  |:::|.:||| ..|.:::::.:.::..:..|:.......
  Fly   682 QQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDE 746

Human   610 TKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQM 674
            ..|| :|...||.::|.||:|.||:.....|.|:||::...||.:||.:...       :|....
  Fly   747 DVSS-QIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSL-------KEGSSR 803

Human   675 EVDEGAGGINGHADSPAPVN-------------GINGYNEDINQESAPKASLRLGFSEYCRISNL 726
            :...|.||..|.|...|.:.             |...:..|..:|...:|.:..|||:...::||
  Fly   804 QGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANL 868

Human   727  726
              Fly   869  868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCM6NP_005906.2 MCM_N 27..114 CDD:405270 23/124 (19%)
MCM 119..657 CDD:214631 147/609 (24%)
Arginine finger 528..531 0/2 (0%)
MCM6_C 713..817 CDD:408078 5/14 (36%)
recNP_001262615.1 RNR_PFL <117..200 CDD:299130 19/85 (22%)
MCM 243..792 CDD:214631 146/607 (24%)
P-loop_NTPase 468..606 CDD:304359 48/143 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 1 1.000 - - FOG0001226
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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