Protein Alignment cv-c and STARD8

DIOPT Version :9

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_005262371.1
• Gene: STARD8 / 9754
• HGNCID: 19161
• Length: 1107
• Species: Homo sapiens
• Alignment Length: 1149
• Identity: 361/1149 - (31%)
• Similarity: 547/1149 - (47%)
• Gaps: 241/1149 - (20%)

  Fly  1377 AEIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMR 1441
            ||.||..||:||:|.|||||.|::|:..||:|:.:|.|:|..|:.|.|.:|.|||..||.||:|:
Human    26 AEAEAKRACEWLQATGFPQYVQLFEEGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMK 90

  Fly  1442 LD---QSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPP-PGLLSLNVEKTES 1502
            |:   || |....|.::..::|...:|.||.||...:.||.:|...|..|| |||.:  ....||
Human    91 LEVHFQS-KQCLSQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPA--TSSCES 152

  Fly  1503 SSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRLR-RSGSERIKDQAK----- 1561
            ...|.|......    ||:..|  .:...:|..|.: ...||...|. ..|.|..:|:||
Human   153 VLTELSATSLPV----ITVSLP--PEPADLPLPGRA-PSSSDRPLLSPTQGQEGPQDKAKKRHRN 210

  Fly  1562 -ALLRRVESIKSRRRKRQNRENVVISGPT---VLDLSQF-----------------------GQR 1599
             :.|:.:||::.:.:....:.....|..|   |...|.|                       |..
Human   211 RSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSG 275

  Fly  1600 SSLRK-----PDAVYSTPP----------SPSALSPMHTFPKAPFFGNDLKVPSHSDNFLSP--- 1646
            ::.||     |.|.:..|.          .|....| .|||::      |.:.|     |.|
Human   276 ANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKP-GTFPRS------LSIES-----LCPEDG 328

  Fly  1647 ----------------NRSSPKRTPTTPRSMRTSPLHFFSSPMSQLKEGKSDD------------ 1683
                            .|.|...|.:...:....|..:.:.|:....|.:.:|
Human   329 HRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLD 393

  Fly  1684 ----------------SSSYYSD-------SQESSTGGKLS------------------------ 1701
                            |.:.|.|       .:|:::..:::
Human   394 DILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPA 458

  Fly  1702 -------------LRKPSKARRFLQRTGKV------------DDIGAHSDSECHQGRKLLIKDAN 1741
                         .:.|::|....|...:.            .:..|||..|......|.:::.:
Human   459 WAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGH 523

  Fly  1742 S-NTTEVKVKKL-TRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQP 1804
            | :.|.....:| :.|.|:|..:......|.::|..|.|..|           |.   |.|..:|
Human   524 SISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDS-----------GV---GASLTRP 574

  Fly  1805 V--VRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERY 1867
            .  :||||||...||::               ::..:......|||:.::.|.:|:.||..||:|
Human   575 CRKLRWHSFQNSHRPSL---------------NSESLEINRQFAGQINLLHKGSLLRLTAFMEKY 624

  Fly  1868 CPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVG 1932
            ...|:.||.|.:|||:::.|.|||:.:.|||||.|:.:||:||.||.:::.|.|:|:...|||||
Human   625 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVG 689

  Fly  1933 IFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVA 1997
            ||||||.||||..||:..|.:.... |   ::.|.||||||:||||||:|||.:.|:|::.||:.
Human   690 IFRKSGVKSRIQNLRQMNETSPDNV-C---YEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQ 750

  Fly  1998 IFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSS 2062
            |:|.||.:..|.|.|.|.|||||||||:|..||.||:.: |::::||||:.||.||||.||||.:
Human   751 IYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDI-ASAEENQMTAGNLAVCLAPSIFHLN 814

  Fly  2063 ISTGSASVSASPRRKGKGS--GMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEK-LSKC-NFS 2123
            :|...   |.|||.|.|.|  |.|..::|::..|:.:.||.||...|:::...::. |..| ::|
Human   815 VSKKD---SPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYS 876

  Fly  2124 YMEESKPLP-------LEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIA 2181
            ..|.|.|.|       .:|.|..:..     |:.|.....:::..|:.:||.|:.  .....::|
Human   877 AAELSPPGPALAELRQAQAAGVSLSL-----YMEENIQDLLRDAAERFKGWMSVP--GPQHTELA 934

  Fly  2182 YKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL 2246
            .:|..||||||||:.|||:..||..||..|:::||.||.:||:.|.::.|....|:|.|..|...
Human   935 CRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMA 999

  Fly  2247 ---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHL 2308
               ..||.|||.|::|||||.|::|..|:|..:..|..| ||.::|.|:||:||||.||||:.|:
Human  1000 PHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESG-VRALMLTSQYLMEPCGLGRSRLTHI 1063

  Fly  2309 ARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHV-ADGPESKV 2351
            .|.|::|::|:||||.:||:|:..:::||.:|..: |.|||:|:
Human  1064 CRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	29/58 (50%)
		RhoGAP_DLC1	1893..2116	CDD:239840	108/224 (48%)
		SRPBCC	2148..2343	CDD:301327	82/197 (42%)
STARD8	XP_005262371.1	SAM_superfamily	31..90	CDD:301707	29/58 (50%)
		RhoGAP	653..867	CDD:295372	108/221 (49%)
		START_STARD8-like	894..1098	CDD:176916	84/211 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3097
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm40592
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.810