DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-c and ARHGAP18

DIOPT Version :9

Sequence 1:NP_001097786.1 Gene:cv-c / 41749 FlyBaseID:FBgn0285955 Length:2351 Species:Drosophila melanogaster
Sequence 2:NP_277050.2 Gene:ARHGAP18 / 93663 HGNCID:21035 Length:663 Species:Homo sapiens


Alignment Length:869 Identity:172/869 - (19%)
Similarity:303/869 - (34%) Gaps:298/869 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1447 KPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEKTESSSKE----- 1506
            ||...:...:...:..::.::|                :||.       |::|:..:|:|     
Human    58 KPPFDRSISQDSLDELSMEDYW----------------IELE-------NIKKSSENSQEDQEVV 99

  Fly  1507 --SSPDRFEEDGAGITLVTPGCSKAGGIPN-DGSSLGEGSDS----GRLRRSGSERIKDQAKALL 1564
              ..||..|.:...:        |..|:.| .|.|.|:..:|    ..|.|:       ||.|:.
Human   100 VVKEPDEGELEEEWL--------KEAGLSNLFGESAGDPQESIVFLSTLTRT-------QAAAVQ 149

  Fly  1565 RRVESIKSRRRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKAPF 1629
            :|||::....||:..:..:    |.|.|:  |.|:                              
Human   150 KRVETVSQTLRKKNKQYQI----PDVRDI--FAQQ------------------------------ 178

  Fly  1630 FGNDLKVPSHSDNFLSPNRSSPKRTP--TTPRSMRTSPLHFFSSPMSQLKEGKSDDSSSYYSDSQ 1692
                              |.|.:..|  |..:|:||:...:         :|:.|::|:..    
Human   179 ------------------RESKETAPGGTESQSLRTNENKY---------QGRDDEASNLV---- 212

  Fly  1693 ESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVKVKKLTRGGS 1757
                                                   |.:.||....:...|.         .
Human   213 ---------------------------------------GEEKLIPPEETPAPET---------D 229

  Fly  1758 LNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFR 1822
            :||           ..||..::.::||:..::.   ..:.|.....|     ||::.        
Human   230 INL-----------EVSFAEQALNQKESSKEKI---QKSKGDDATLP-----SFRLP-------- 267

  Fly  1823 KCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIK 1887
                      ::..|......::...::.:..|||:.||...:..      |...:..|.: |||
Human   268 ----------KDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVL------GIELKQQKAV-KIK 315

  Fly  1888 MPDYKDKKVFGVPLLMILQRS-----GQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLR 1947
            .   ||..:|.|||..:|::.     |..:||..:.....::...|:..|:.|..|...||..|.
Human   316 T---KDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLC 377

  Fly  1948 EQIEVT--DSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPA-EVRLD 2009
            :::|..  :.|.....|    :.:|.|.:||.:.||||:.||:.:..:.|.|: |:||. :.:|.
Human   378 QELEAKFYEGTFNWESV----KQHDAASLLKLFIRELPQPLLSVEYLKAFQAV-QNLPTKKQQLQ 437

  Fly  2010 AVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIF--HSSISTGSASVSA 2072
            |:...|:||||.||:.|..|||||..|..|.::|:||..|:.:.:|.::|  |:           
Human   438 ALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHA----------- 491

  Fly  2073 SPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEESKPLPLE 2134
                  .|....:.:|...|..:...:..:|::.|.::|..|   .::.|.|....::.|....:
Human   492 ------LGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKK 550

  Fly  2135 ALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTE 2199
            .|         :...|:      :|..||     ...|.||:.|.....:|...|   |.:.|..
Human   551 LL---------KKMAYD------REKYEK-----QDKSTNDADVPQGVIRVQAPH---LSKVSMA 592

  Fly  2200 I----EGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQLTTDFCVLRSWQTDL 2260
            |    |....:||...:.|.:.      ..||:||    .|::.|.:.|.:........::..||
Human   593 IQLTEELKASDVLARFLSQESG------VAQTLKK----GEVFLYEIGGNIGERCLDDDTYMKDL 647

  Fly  2261 ----PRGACVIVETSIDHAKAKPL 2280
                |....||        |:|||
Human   648 YQLNPNAEWVI--------KSKPL 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-cNP_001097786.1 SAM_DLC1,2-like 1382..1441 CDD:188937
RhoGAP_DLC1 1893..2116 CDD:239840 65/235 (28%)
SRPBCC 2148..2343 CDD:301327 33/141 (23%)
ARHGAP18NP_277050.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 179..227 13/99 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..277 7/59 (12%)
RhoGAP_ARHGAP18 321..534 CDD:239856 64/234 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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