DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-c and ARHGAP28

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001353159.1	Gene:	ARHGAP28 / 79822	HGNCID:	25509	Length:	729	Species:	Homo sapiens

Alignment Length:	716	Identity:	152/716 - (21%)
Similarity:	262/716 - (36%)	Gaps:	202/716 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1446 HKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEKTESSSKESSPD 1510
            |.|...:...|:..::.::.:.|.....|:. |.:|  |.|.|||      .|.|.....|...:
Human    60 HPPAFSRSNSEASVDSASMEDFWREIESIKD-SSMG--GQEEPPP------AEVTPVDEGELEAE 115

  Fly  1511 RFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRLRRSGSERIKDQAKALLRRVESIKSRRR 1575
            ..::.|.. ||:      :|....||.:|            .|...:.||.|:.:|..:.....|
Human   116 WLQDVGLS-TLI------SGDEEEDGKAL------------LSTLTRTQAAAVQKRYHTYTQTMR 161

  Fly  1576 KRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKAPFFGNDLKVPSHS 1640
            |:                    .:.|:|....::....||    |..|      .||      |:
Human   162 KK--------------------DKQSIRDVRDIFGVSESP----PRDT------CGN------HT 190

  Fly  1641 DNFLSPNRSSPKRTPTTPRSMRTSPLHFFSSPMSQLKEGKSDD---SSSYYSDSQESSTGGKLSL 1702
            :..     ...|.....||.::||.    |.|         ||   :|:..||:.:...|.....
Human   191 NQL-----DGTKEERELPRVIKTSG----SMP---------DDASLNSTTLSDASQDKEGSFAVP 237

  Fly  1703 RKPSKARRFLQRTGKVDDIGAHSDSECHQGR-------------KLLIKDANSNTTEVKVKKL-T 1753
            |..|.|  .|:   .:..:..||:.....|:             |.:..:|...:.||...:: |
Human   238 RSDSVA--ILE---TIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVT 297

  Fly  1754 RGGSLN-LGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERP 1817
            .....| |.|...|::.:..:.|           |.:.|....|..|.
Human   298 EALKRNKLKKSEIKKEDYVLTKF-----------NVQKTRFGLTEAGD----------------- 334

  Fly  1818 NMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKF 1882
                                      :||..::.||.|:|:.||...:.:      |...:..|
Human   335 --------------------------LSAEDMKKIRHLSLIELTAFFDAF------GIQLKRNK- 366

  Fly  1883 IKKIKMPDYKDKKVFGVPLLMIL-----QRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSR 1942
            .:|:|   .:|..:|||||.::|     :..|..:||.::..|..::.:.|:..||||.||..::
Human   367 TEKVK---GRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAK 428

  Fly  1943 IMKLREQIEVTDSTAECMDVF--DLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLP-A 2004
            :.:.||:::...:.    |.|  |.....:.|.|||.:|||||.||...:....|:::.:..| .
Human   429 VKQYREELDAKFNA----DKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV 489

  Fly  2005 EVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSAS 2069
            :|:..|:...|:.|||.||:....|:.|...|.||..:|:|:..|:...:|.::|.|
Human   490 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFS-------- 546

  Fly  2070 VSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEESKPL 2131
                   :.|.|   |.:||..|..:...:..|:::.|.::....   .::.:.|.:.|...|.|
Human   547 -------RSKHS---DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQL 601

  Fly  2132 P 2132
            |
Human   602 P 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	63/233 (27%)
		SRPBCC	2148..2343	CDD:301327
ARHGAP28	NP_001353159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..105		13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..236		20/93 (22%)
		RhoGAP_ARHGAP18	377..588	CDD:239856	62/232 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810