Protein Alignment cv-c and stard13

DIOPT Version :9

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_031751944.1
• Gene: stard13 / 734093
• XenbaseID: XB-GENE-478898
• Length: 1349
• Species: Xenopus tropicalis
• Alignment Length: 1499
• Identity: 426/1499 - (28%)
• Similarity: 677/1499 - (45%)
• Gaps: 360/1499 - (24%)

  Fly  1061 GAVDEDNNSTSSSS-----ACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTA---TPPKDMSH 1117
            |.:::::||..|.|     ..|.......:|::..|..   ::.::|...:||.   .||
 Frog     3 GLLEDEDNSFYSMSYMHFLTAENMPYQFPAGRNEYSRQ---MEINDNILAMGTKIANLPP----- 59

  Fly  1118 YWKSHHLQHHH----HHHHRKC---TGSAQDNESVSSL--------------------------- 1148
                  ::.||    ....|.|   .|....:|.|...
 Frog    60 ------IKEHHVTLTETEERPCCVMVGKEFKSEEVGGAILYPPLAETNHFLAANANAKTRYIQVV 118

  Fly  1149 ----EALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLDEEKDKMSKSQDYDEIWD 1209
                .|:....|....|:..:..|::|.           :|:.:|           .:.|||
 Frog   119 EHEPSAILFRDFSLDSSIPGAIAPNILN-----------SETSED-----------KEVYDE--- 158

  Fly  1210 CDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHYHSPQPLVHPRKVLPIHH 1274
                |.:..|...|...|..|                         ||.|..|.:...:..||..
 Frog   159 ----DEEEESDENGDVFTELP-------------------------HYESMFPGLRRNQCHPISL 194

  Fly  1275 HALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASLHSGLGDSGGIQELCTKS 1339
            :.         :::...|....:||.:.:.|.|             :|:.|.|::...:......
 Frog   195 NG---------NIIFNFEDVCQILSSTQSGAEQ-------------TLNEGEGNNLMEERYRWSE 237

  Fly  1340 NSAPMLLKEREMSRRFD----------NFEAQHLTLRYSRS-QSDRYLAEIEAVEACKWLRAAGF 1393
            :...:::|..:::...:          |......:.:.:.| .:||...|:||.|||.|||||||
 Frog   238 SMTCLMMKLEQLNVDIEDAVMAGVSSLNLSPTDCSTQLANSLVTDRGSPELEAKEACDWLRAAGF 302

  Fly  1394 PQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESD 1458
            |||||:|||.|||||:.:|.:||..|:.|.::.|.|||..||:||:|:||.|.:   .::.|:||
 Frog   303 PQYAQLYEDSQFPIDIASVKRDHDFLDRDHVEPLCRRLKTLNKCASMKLDVSFQ---RKKSEDSD 364

  Fly  1459 DENF-ALSEHWTFQPHIRRWSRI----------------GEMG---------LELPPPGLLSLNV 1497
            :|:. |:|:.|.||...|:|||:                |||.         .:|..|.:.|::.
 Frog   365 EEDLCAISDKWRFQRLSRQWSRVDDIDSLFERSERLGSSGEMKNTTSSESVLTDLSEPEICSIHS 429

  Fly  1498 EKTESS-------SKESSPDRFE-------EDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRL 1548
            ..:..|       ...:|.:.||       .|...:|::.|.       |.|.|       .|:|
 Frog   430 GSSGGSDCRCSYVGNSASRETFECADTMCIHDPNSMTILPPW-------PKDVS-------DGKL 480

  Fly  1549 RRSGSERIKDQAKALLRRVESIKSR----RRKRQNRENVVISGPTVLDLS--------------- 1594
            .....:...::.|..|:.:.:::|:    :.|...|...::....:|.|.
 Frog   481 NAKNEKPAHNKTKTFLKCMGTLRSKGTYGKSKGLQRTGAIVISEPILQLEPEPLKPIPQLEPDPL 545

  Fly  1595 ----------------QFGQRSSLRKPDAVYSTPPSPSALSPMHTF---PKAPFFGNDLKV---- 1636
                            .|....:|.....:.::..|...|..|...   .:...:..|:.|
 Frog   546 KTMSCVGNGQVQDSSMNFTATGNLNSVSEIQTSTESSPCLKEMQALEPNKRGGMYLEDIDVFTDL 610

  Fly  1637 ------PSHSDNFLS--------PNRSSPKRTPTTPRSMRTSPLHFF--------SSPMSQLKEG 1679
                  .:|:.:|.|        |....|...|........||...|        ..|:|:.|..
 Frog   611 GTAKAGHNHNHDFHSQEDLVVHIPKDHKPGTFPKALSIESLSPTENFYGVNWRSGGIPLSRQKGI 675

  Fly  1680 KSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGKV-----DDIGAHSD-----------SE 1728
            ::.:....   |...|.|.:||:............||.:     ||:..|.|           |.
 Frog   676 RAKEPRIM---SSRCSRGSRLSVYDNVPGSHLYASTGDLMDLDRDDLFPHLDDVLQHINGLQQSV 737

  Fly  1729 CHQGRKLL--IKDANSNTTEVKVKKLTRGGSLNLG-KDPKKRDGFRSSSFRSRSTSRKEAK---- 1786
            .|..:.::  ::|.:.:..|        .|:.|.. .:|...| |..:|.....|:..:.:
 Frog   738 YHWSKDIMPDLQDDDFSVGE--------SGTSNFHLPNPMSMD-FEGNSISDGRTTPSDMERDAT 793

  Fly  1787 --NDEDT----------AGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAG-G 1838
              ||.||          .||:....::|   .||.|||:..:                |..:| .
 Frog   794 SLNDSDTTGTRERRDSGVGASLTRTNRR---FRWSSFQLSHQ----------------QSSSGAS 839

  Fly  1839 MPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLM 1903
            :..:..|||||.:::|.:|:.||..||:|..|::.||.|.:|||:|::|.||:|||.:|||||::
 Frog   840 LQISNQSAGQLNLLQKFSLLRLTAIMEKYSLSNKHGWTWSVPKFMKRMKGPDFKDKTIFGVPLMV 904

  Fly  1904 ILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQA 1968
            .:||:||.||.:::.|.|:|:.:.|||||:|||||.||||..||:..|.........|    |.|
 Frog   905 HVQRTGQPLPQSIQQALRFLRSHCLDQVGLFRKSGVKSRIQALRQMNETASENVSYED----QCA 965

  Fly  1969 YDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFL 2033
            ||||||:||:||:|||.|||:|:.|||:.|:|::|.:.||.|||.|::|:.|||||:|..||.||
 Frog   966 YDVADMMKQFFRDLPEPLLTSKLGETFLHIYQYVPKDQRLQAVQSAIMLMSDENREVLQTLLCFL 1030

  Fly  2034 TIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPR--RKGKGSGMPDMKELAEAKASH 2096
            :.| .:.::||||..||.||||.|:||.::    .....|||  :|...:|.||.|:|.|..|:.
 Frog  1031 SDV-TSVEENQMTPMNLAVCLAPSLFHLNL----LKKDNSPRAIQKKYATGRPDQKDLNENFAAT 1090

  Fly  2097 ECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEALGEGMQFHNWRGYLYECTSATI--- 2157
            :.|:.||....:::....:.:::...||:| :...|.:|.||:  |.....|.:.....:||
 Frog  1091 QGLAHMIMECNRLFEIPHDVIAQSRNSYVEADVHVLTMEELGK--QLEEEGGSVSTYFESTIQGL 1153

  Fly  2158 -KEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTN 2221
             ||.:||.:||.|::|..::  |:||||||||:.||:|:.|.|:|.||..||..::::|..||.:
 Frog  1154 QKEAKEKFKGWMSLSSAENT--DLAYKKVGDGNSLRVWKVSVEVEAPPSVVLNRILRERQLWDDD 1216

  Fly  2222 LLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGA 2283
            |||.:.::.||::||:|||.|:...   :.||.|||||:||||:|.|.:...|::|.:|. |.|.
 Frog  1217 LLQSKVIESLDNQTEVYQYVLNSMAPHPSRDFVVLRSWRTDLPKGICALAAVSVEHDEAH-LIGG 1280

  Fly  2284 VRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHVA-DGP 2347
            ||..||.:||||||||||:|::.|::|||:||.:||||||.:||:|:....|||.:|:.:: :||
 Frog  1281 VRAAVLDTRYLIEPCGSGKSKLTHISRVDLKGHSPEWYNKCFGHLCASEALRIRNSFQPISTEGP 1345

  Fly  2348 ESKV 2351
            |:|:
 Frog  1346 ETKI 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	36/58 (62%)
		RhoGAP_DLC1	1893..2116	CDD:239840	104/224 (46%)
		SRPBCC	2148..2343	CDD:301327	95/201 (47%)
stard13	XP_031751944.1	SAM_DLC2	287..350	CDD:188991	39/62 (63%)
		RhoGAP_DLC1	894..1109	CDD:239840	104/223 (47%)
		SRPBCC	1136..1340	CDD:417480	96/206 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm47768
Panther	1	1.100	-	-	O	PTHR12659
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100