DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-c and Dlc1

DIOPT Version :9

Sequence 1:NP_001097786.1 Gene:cv-c / 41749 FlyBaseID:FBgn0285955 Length:2351 Species:Drosophila melanogaster
Sequence 2:NP_001357926.1 Gene:Dlc1 / 58834 RGDID:68416 Length:1542 Species:Rattus norvegicus


Alignment Length:1564 Identity:455/1564 - (29%)
Similarity:698/1564 - (44%) Gaps:373/1564 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1058 RSVGAVDEDNNSTSSSSACEEATGVLSSGKSGISLDSSGLDND---NNESGIGTATPPKDMSHYW 1119
            |.:|.:..:.:.:.|....|....:.:|.::.:.:.....|:|   .|:|.|   .||       
  Rat    76 RPMGHISPEVDESDSQEGEERFLSLEASTETLVHISDEDTDSDLHLINDSQI---LPP------- 130

  Fly  1120 KSHHLQHHHHHHHRKCTG------------SAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLE 1172
                 |.|....|....|            |:||:.:..::....::...:.|. ...|...:.:
  Rat   131 -----QRHERDSHESVKGAGSFRKTLSTMQSSQDSHNTWTMAGEAEISAAEGGE-ERKDGDTISK 189

  Fly  1173 VLSQC--GSGGEANE-----------SQDD------MLDE---EKDKMSKSQDYDE--------- 1206
            .|..|  .|..|.||           ::||      :||.   .||...::|..|.         
  Rat   190 SLEHCKSTSASETNEVAKVNTFQSLNAKDDITPKTQLLDSLVLVKDVTPETQLLDSAVIAQQHRK 254

  Fly  1207 -------------------------------IWDCDCTDGDASSASGGGGVTATPVILR---RKY 1237
                                           :...||........|..||::|...:.|   .:|
  Rat   255 PDFPNDDQEKNLHHVVEEDFLVAPYTDRGLPLLKADCGSCLLRPPSCPGGMSAENDLERSGFSEY 319

  Fly  1238 TAPPPILVPRTQRSHSLDHYHSP---------QPLVHPRKVLPIHHHALKSKERGQL-SLVLR-- 1290
            ....|:.|.:......| |...|         |..:..||      ...:.::|.:| |:||.  
  Rat   320 QNKSPLRVSQEGVMQCL-HVRGPVTTQETGDNQVRLRKRK------ETREDRDRTRLDSMVLLIM 377

  Fly  1291 ---------QEPFQSLLSPSATAANQLHHFVELPSPSSASLHS--------GLGDSGGIQELCTK 1338
                     :....:..|||:|..|...|..:|.|.|.:...|        .|............
  Rat   378 KLDQLDQDIENALSAASSPSSTPTNLRRHVPDLESGSESGTESITVNQTQVNLSSESTDPSSTPA 442

  Fly  1339 SNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYEDH 1403
            |||.   .|.:.|:               ....:::..|||||.|||.|||..|||||||:|||.
  Rat   443 SNSG---TKPKAMA---------------VPCIAEKETAEIEAKEACDWLRVTGFPQYAQLYEDL 489

  Fly  1404 QFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESDDENFALSEHW 1468
            .||||:..|.::|..|:.|.:::|.|||..||:||.|:|:.|  |...:.::..::|..|:|..|
  Rat   490 LFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEIS--PHRKRSEDSDEEEPCAISGKW 552

  Fly  1469 TFQPHIRRWSRIGEMGL----ELPPPGL------------------LSLNVE----KTESSSKES 1507
            |||...:||||:.|..:    :.|.||.                  ||.:.|    ::.||:..|
  Rat   553 TFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSRESMLTDLSEHQEVSSIRSLSSTSSS 617

  Fly  1508 SPDRFEEDGAGIT----LVTPGCSKAGGIPNDGS-----SLGEGSDSGRLRRSGSERIKDQAKAL 1563
            :|......|...|    .|...||.:..:.|:.|     |..|.|......:...:..|.:.::|
  Rat   618 APTHVPHSGEATTPRTNSVISVCSSSHFVGNEDSFSSLPSPKELSSFSFSMKGHEKNTKSKTRSL 682

  Fly  1564 LRRVESIKSR-----RRKRQNRENVVISGP----------------------------------- 1588
            |:|:||:|.:     :.|..::..::||.|                                   
  Rat   683 LKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEEKLKQLNCVEISALNGNHINVPMVRKR 747

  Fly  1589 TVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKA---------PF----FGNDLKVPSHS 1640
            :|.:.:|....||..:..:..|||...:....:.|..|.         ||    |.|..:     
  Rat   748 SVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMYLEGFDPFSQSAFNNVTE----- 807

  Fly  1641 DNFLSPNRSS-PKRT----------PTTPRSM---------------RTSPLHFFSSP--MSQLK 1677
            .|:  .||.| |:.|          .|.|:::               ||...|   .|  :|..:
  Rat   808 QNY--KNRESYPEDTVFYIPEDHKPGTFPKALSNGSFCPSGNSSVNWRTGSFH---GPGHLSLRR 867

  Fly  1678 EGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTG------------KVDDIGAH------ 1724
            |..||........:..||...::|:............:|            ::|||..|      
  Rat   868 ENSSDSPKELKRRNSSSSVSSRMSIYDNVPGSILYSSSGELADLENEDIFPELDDILYHVKGMQR 932

  Fly  1725 --------------------SDSECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKDPKKRDG 1769
                                |.|.|....|.:..|.:.:.........| |.|||..::|     
  Rat   933 IVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDST-GNSLNEPEEP----- 991

  Fly  1770 FRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQE 1834
                      |...| :.|.....:.|.....|   :||||||...||::               
  Rat   992 ----------TDIPE-RRDSGVGASLTRCNRHR---LRWHSFQSSHRPSL--------------- 1027

  Fly  1835 DAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGV 1899
            ::..:.....|..|:.:::|.:|:.||..:|:|.||::.|::|.:|||:|:||:|||||:.||||
  Rat  1028 NSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGV 1092

  Fly  1900 PLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFD 1964
            ||.:.:|||||.||.:::.|.|:|:.:.|||||:|||||.||||..||:..|    :||....::
  Rat  1093 PLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNE----SAEDYVNYE 1153

  Fly  1965 LQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVL 2029
            .|.|||||||||||||:|||.|:|.|:||||:.|:|::|.:.||.|::.|::||||||||:|..|
  Rat  1154 GQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTL 1218

  Fly  2030 LEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPR--RKGKGSGMPDMKELAEA 2092
            |.||:.|.|..::||||..||.||||.|:||  ::|.... ::|||  ::.:..|.||.|:|.|.
  Rat  1219 LYFLSDVTAAVKENQMTPTNLAVCLAPSLFH--LNTLKRE-NSSPRVMQRKQSLGKPDQKDLNEN 1280

  Fly  2093 KASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEALG--EGMQFHNWRGYLYECTS 2154
            .|:.:.|:.||...|::: ...|::|:|..||.| |.|||.|||||  ...|..::|.:|.:|..
  Rat  1281 LAATQGLAHMIAECKKLF-QVPEEMSRCRNSYTEQELKPLTLEALGHLSNDQPADYRHFLQDCVD 1344

  Fly  2155 ATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWD 2219
            ...||.:||.:||.|..:  ....:::||||.:|.||||||.:.|:...|:|:|:.::|::..||
  Rat  1345 GLFKEVKEKFKGWVSYPT--SEQAELSYKKVSEGPPLRLWRATIEVPAAPEEILKRLLKEQHLWD 1407

  Fly  2220 TNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLF 2281
            .:||..:.::.||.:||||||..:...   ..|:.|||:|:|:||||||.::.||:||.:| |:.
  Rat  1408 VDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPRGACALLFTSVDHDRA-PVA 1471

  Fly  2282 GAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHVADG 2346
            | ||..||.|||||||||||:|::.::.|.|::|..||||.|::||:|:..:.:||.:|.:  ..
  Rat  1472 G-VRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYTKSFGHLCAAEVVKIRDSFSN--QS 1533

  Fly  2347 PESK 2350
            .|||
  Rat  1534 TESK 1537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-cNP_001097786.1 SAM_DLC1,2-like 1382..1441 CDD:188937 32/58 (55%)
RhoGAP_DLC1 1893..2116 CDD:239840 110/224 (49%)
SRPBCC 2148..2343 CDD:301327 86/197 (44%)
Dlc1NP_001357926.1 SAM_DLC1 468..527 CDD:188990 32/58 (55%)
RhoGAP_DLC1 1086..1304 CDD:239840 111/225 (49%)
SRPBCC 1329..1532 CDD:417480 88/208 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 196 1.000 Domainoid score I3033
eggNOG 1 0.900 - - E1_KOG2200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001209
OrthoInspector 1 1.000 - - otm44733
orthoMCL 1 0.900 - - OOG6_103453
Panther 1 1.100 - - LDO PTHR12659
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X752
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.810

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