DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-c and dlc1

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_017211480.1	Gene:	dlc1 / 567965	ZFINID:	ZDB-GENE-130206-12	Length:	1669	Species:	Danio rerio

Alignment Length:	1661	Identity:	485/1661 - (29%)
Similarity:	728/1661 - (43%)	Gaps:	415/1661 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   970 QLSGGDMETMLASQPMSMPKRVGINHAVLTSRNAITPPPASASSASQSAASVHSAKGSSSAGTTP 1034
            |...||.:....::. .:...:.::|.|         |.|.|...:....:| ...|.|...|..
Zfish   129 QTHNGDADNKKLNKD-KVSSAISLSHLV---------PSAEALDQTNGLGNV-LKDGISLNNTVK 182

  Fly  1035 GYLVDVTKKGSTSTIWTSEESILRSVGA---VDEDNNSTSSSSACEEATGVLSSGKSGISLDSSG 1096
            ....::|.....:::..:|..:..:||:   |.|..|.|||.:   |.|     .|...| |||.
Zfish   183 EDCSELTHPKEETSVENTESMVKVNVGSEKLVYEHMNVTSSIT---EIT-----NKPPTS-DSSA 238

  Fly  1097 LDNDNNESG-------------IGTATPPKDMSHYWKSHHLQHHHHHHH-----------RKCTG 1137
             |..:||.|             |.|....|.||   .|...|..||..|           :.|..
Zfish   239 -DPCDNEEGHCCETSEQAILKCIKTERSSKPMS---SSSTSQEDHHIPHTEDANKANLACKDCNM 299

  Fly  1138 SAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEV------------LSQCGSGGEANESQDDM 1190
            :.::|                ...:....|.|.|.|            |.:||        ..|:
Zfish   300 TPEEN----------------GDGIFKCADGDTLNVGCINPHACESSQLKECG--------VIDI 340

  Fly  1191 LDEEKDKMSKSQDYDEIWDCDCTD-GDASSA--SGGGGVTATPVILRRK----YTAPPPILVPRT 1248
            :|...|..||.|   .|.:..|.: ||.|||  ||.|....|...|..:    .||...:..|:.
Zfish   341 MDTWHDCSSKLQ---TIHEGSCPESGDDSSAQISGDGPEEPTCRGLNTRNCENLTASEDLREPQP 402

  Fly  1249 QRSHSLDHYHSPQPLVHPRKVLP------------IHHHALKSKERGQL-SLVL-------RQEP 1293
            :..:. ||..:........:::|            ...|..:.|||.:| |:||       ..:.
Zfish   403 EGIYE-DHQATQNTAAKDCEMVPKADGSIVKLRTRKSSHEEREKERSRLDSMVLLIMKLDQLDKE 466

  Fly  1294 FQSLLSPSATAANQLHH----FVELP--------SPSSASLH-------SGLGDSG--GIQELCT 1337
            .::.||.|..:...|..    .|:|.        |.||.||:       |.|..||  |......
Zfish   467 IENALSSSLNSTPNLKRRIISDVDLETLDSAGSLSASSQSLNTPLYRSSSSLSSSGPTGTPGARP 531

  Fly  1338 KSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYED 1402
            |:.::.:|                        |::||  |||||.|||.||||||||||||:|||
Zfish   532 KNETSAVL------------------------SENDR--AEIEAKEACTWLRAAGFPQYAQLYED 570

  Fly  1403 HQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQK--EESD-DENFAL 1464
            .||||::::|.:||..|:.|.:::|.|||..||:||.|||:     .|||:|  |:|| ||..|:
Zfish   571 GQFPIEISSVTRDHDFLDQDAIEALCRRLNTLNKCALMRLE-----ITPQRKRSEDSDEDEPCAI 630

  Fly  1465 SEHWTFQPHIRRWSRIGEMGLELPPP---------GLLS---------LNVEKTESSSKESSPDR 1511
            |..||||...:||||:.::.|::..|         ..||         |..|...:|.:....|.
Zfish   631 SGRWTFQRDSKRWSRMDQLDLDVFSPTAGDTGSFAAFLSQDEHFVRGPLQKEGVNASVESILTDL 695

  Fly  1512 FEEDGAGI-----------------------------TLVTPGCSKAGGIPNDGSSLGEGSDS-- 1545
            .|:...|.                             |..|...|....:.:.|:| |...||
Zfish   696 SEQPEVGSLHSTGSGGRGGSLSTTVPSSPATTISNANTATTTRASSVASVCSSGTS-GANEDSMS 759

  Fly  1546 -----------------GRLRRSGSER-IKDQAKALLRRVESIK--------SRRRKR--QNREN 1582
                             ..|..|.:|: .:.:||:.|:|:||::        |:|:|:  .....
Zfish   760 DGLPSPLERGTFAFDVKPNLISSAAEKSTRSRAKSFLKRMESLRLRTSSNAGSKRKKKGVPGHGR 824

  Fly  1583 VVISGPTV--------------LDLSQFGQRSSLRKPDAVYST---------------------P 1612
            :.||||.:              :|::.. .|::.|.....|||                     .
Zfish   825 LEISGPVLKEGLDEDKLRRLNCVDIATL-DRNANRNRSISYSTQTSSGSAGSSQSEASSGSAVST 888

  Fly  1613 PSPSALSPMHTFPKA-------------PF------------------FGNDLKVPSHSDNFLSP 1646
            |||.:.:..|:....             ||                  ..|..|.||.:|.....
Zfish   889 PSPVSRARSHSTAAGSSKRGGMYLEGFDPFNFVVLQPSEDQDVKENHQTQNKRKEPSSTDENNRR 953

  Fly  1647 NRSSPKRTPTTPRSMRTSP--LHFFSSPMSQLKEGKSD--------DSSSYYSDSQESSTGGKLS 1701
            ||.|...........|...  :.||..|     ||...        |..||:.....|
Zfish   954 NRQSSDNRQMEDEESRVEEGGVIFFYLP-----EGHKPGTFPKALADGGSYHGVDNTS------- 1006

  Fly  1702 LRKPSK--------ARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVK--VKKLTRGG 1756
             |:|.:        :|..:.......::|...|....:..||  :|.......::  |.:....|
Zfish  1007 -RRPPRRGSSASLDSRMSIYDNVPFSEVGDDEDEVGEEEPKL--EDVLERVRGLQQLVNEWPETG 1068

  Fly  1757 SLNLGKDPKKRDGFRSSSFRSRS--------TSRKEAKN--DEDTAG------------------ 1793
            .....:|.::.:|...|:..|.|        ...:|.:|  |:|:.|
Zfish  1069 IGEEEEDEEEEEGDSDSALDSASPCPSSPLQNRLEETENGSDQDSTGNPLAERDETLSSRERCDS 1133

  Fly  1794 ---ATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKL 1855
               |:....::.|. :||.|||...||::      |..:         :.....|..|:.:::|.
Zfish  1134 GVEASLTRANRTQK-LRWPSFQSSHRPSL------SSTV---------LQVGCQSVLQMNLLQKY 1182

  Fly  1856 ALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAF 1920
            :|:.||..:|||.|:::.|::|.:|||:|:||:.||||:.||||||.:|:|||||.||.:::.|.
Zfish  1183 SLLKLTALLERYTPTNKHGFSWAVPKFMKRIKVRDYKDRSVFGVPLQVIVQRSGQPLPQSIQQAM 1247

  Fly  1921 RWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPES 1985
            |:|:...|||||:|||||.||||..||:..|...:....:: ::.|.|||||||||||||:|||.
Zfish  1248 RYLRSQCLDQVGLFRKSGVKSRIQALRQMNESCGAVGGGVN-YEGQLAYDVADMLKQYFRDLPEP 1311

  Fly  1986 LLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNL 2050
            |||:|:|:||:.|:|::|.|.||.||:.|||||||||||.|..||.||:.|.|:..:||||..||
Zfish  1312 LLTSKLSDTFLQIYQYVPKEQRLQAVRAAVLLLPDENREALQTLLCFLSDVTASVGENQMTCTNL 1376

  Fly  2051 GVCLAQSIFHSSISTGSASVSASPRRKGKGS--GMPDMKELAEAKASHECLSFMIEHYKQIYTAA 2113
            .||||.|:||.:.....   |:|||...:.:  |.||.::|.|..|:...|:.||:..:::: ..
Zfish  1377 AVCLAPSLFHLNTLRRE---SSSPRVMNRKNTLGKPDQRDLNENLAATHGLAHMIQECRKLF-QI 1437

  Fly  2114 KEKLSKCNFSYMEES-KPLPLEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSS 2177
            .|::|:|..||||:. .|:.:|.|.|.....|::..|.:...:.:||.::|.:|:.|.::  ..:
Zfish  1438 PEEMSRCRNSYMEQGLSPMRMEVLAENCGSCNYQSLLKDSIDSLLKEAKDKFKGYDSCST--PEN 1500

  Fly  2178 VDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQY-- 2240
            .::|||||.||..||.|:...::....::||:.:::::..||.:||:.:.|:.||..||:|||
Zfish  1501 AELAYKKVQDGSSLRQWKVCVDVPASAEDVLQRILREQERWDEDLLESRIVETLDHNTEVYQYVR 1565

  Fly  2241 -ALDGQLTTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSR 2304
             ::......|..|||||.||||:|.|.:|..|:||..|..|  .||..||.|||.|||||:.:||
Zfish  1566 NSMPPHPPRDHVVLRSWMTDLPKGVCTLVSVSVDHESAAVL--GVRANVLTSRYYIEPCGANKSR 1628

  Fly  2305 VMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAF 2340
            :.|::|:|.:|:.||||||.|||:|:..:.|||..|
Zfish  1629 LAHISRIDCRGRCPEWYNKLYGHLCAAEVVRIRDTF 1664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	35/58 (60%)
		RhoGAP_DLC1	1893..2116	CDD:239840	111/224 (50%)
		SRPBCC	2148..2343	CDD:301327	80/196 (41%)
dlc1	XP_017211480.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3074
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I926
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm25015
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	LDO	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.890