Protein Alignment cv-c and stard13a

DIOPT Version :9

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_683100.5
• Gene: stard13a / 555484
• ZFINID: ZDB-GENE-091116-18
• Length: 1138
• Species: Danio rerio
• Alignment Length: 1129
• Identity: 388/1129 - (34%)
• Similarity: 566/1129 - (50%)
• Gaps: 227/1129 - (20%)

  Fly  1378 EIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRL 1442
            ||||.|||.||||||||||||:|||.||||:::.|.:||..|:.|.::.|.|||..||:||:|:|
Zfish    82 EIEAKEACDWLRAAGFPQYAQLYEDSQFPIEISAVKRDHDFLDKDLVEPLCRRLNTLNKCASMKL 146

  Fly  1443 DQSHKPQTPQQKEESDDEN--FALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEKTESSSK 1505
            |.|    .|::|.|..||.  .|:|..|||:.:.|||||:.::...|              ..::
Zfish   147 DVS----LPKKKSEDSDEEDLLAISNRWTFEWNSRRWSRLQDIDYLL--------------GRAE 193

  Fly  1506 ESSPDRFEEDGAGITLVTPG------------CS-----KAGGIPNDGSSLGE----------GS 1543
            |.||   .|.|.|:......            ||     ....:| |.:||..          ||
Zfish   194 ERSP---SEVGEGLRTTVSSESILTDLSEPEICSLHSEDSLAAMP-DSASLTPLHLPRELPHYGS 254

  Fly  1544 DSGRLRRSGSERIKDQAKALLRRVESIK---SRRRKRQNRENVVISGPTVLDLSQFGQRSSLR-- 1603
            ...:.||.|..|.||    .|||:|::.   .....|..|.::|||.|.:  .|:.....:||
Zfish   255 LPAKSRRRGRTRAKD----FLRRMETLGRTWGPSMGRSERRSLVISSPVL--QSEPEALKTLRCV 313

  Fly  1604 -----KPDAVYSTPPS---PSALSPMHTFPKAPFFGNDLKVPSHSDNFL---------------- 1644
                 .|....:|||:   |::|.......::...|:....|:::....
Zfish   314 QIFNGAPINAENTPPADNLPNSLPSSEASSQSETSGSAGSTPNNAGRLSKLYPPGKRAGVYLEDI 378

  Fly  1645 -----SPNRSSP----------------------KRTPTTPRSMRTSPLHFFS------------ 1670
                 :|.|..|                      .:..|.|:::....|...:
Zfish   379 DVLAGAPQRRRPVEQSRKNEFRSYDELLVHIPKDHKPGTFPKALSIESLTLANKEHGNWKVLDSE 443

  Fly  1671 -SPMSQLKEGKSD-----------DSSSYYSDSQES----STGGKLSLRKPSKARRFLQRTGKVD 1719
             .|....|.|..:           ...|.|.:...|    |||..|.|.|              :
Zfish   444 PQPFKCRKVGGREVRPVTRCCPRGSRISVYDNVPGSHLYASTGDLLDLEK--------------E 494

  Fly  1720 DIGAHSDS--ECHQGRKLLIKDANSNTTEVKVKKLTRG-GSLNLGKDPKKRDGFRSS----SFRS 1777
            ||..|.|.  :...|.:.::...:.|     |...:.| |....|:|.:..||..||    .|..
Zfish   495 DIFPHLDDILQHVNGLQQIVDHWSKN-----VLPESEGEGDGGRGQDKRMIDGQSSSQITLDFEG 554

  Fly  1778 RS-----TSRKEAK------NDEDTAGATTN-----GGSKRQPVVRWHSFQMEERPNMIFRKCFS 1826
            .|     |:..:..      ||.||:.....     |.|..:|.:||.||:|.   |::.:...|
Zfish   555 TSVIEGLTTPSDGNRDGVSLNDTDTSSTRERRDSGVGASLTRPRLRWPSFRMS---NLLSQSGIS 616

  Fly  1827 KKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDY 1891
            .:|            ::.|.|||.:::|.:|:.||..||:|..|::.||.|.:|||:|:||.|||
Zfish   617 LQI------------SSQSVGQLSLLQKFSLLRLTAIMEKYSMSNKHGWTWSVPKFMKRIKGPDY 669

  Fly  1892 KDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDST 1956
            |||.||||||::.:||.|..||:.::.|.|:|:...|||||:|||||.||||..||:..|.:...
Zfish   670 KDKTVFGVPLIVHVQRYGHPLPMCLQLALRFLRSQCLDQVGLFRKSGVKSRIQALRQMCETSPEN 734

  Fly  1957 AECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDE 2021
            ..    :|.|.|||||||:||:||:|||.|||:||.|||:.|:|::|.|.||.|||.|::|:.||
Zfish   735 VN----YDDQSAYDVADMVKQFFRDLPEPLLTSKMGETFLHIYQYVPKEQRLQAVQAAIMLMADE 795

  Fly  2022 NREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPR--RKGKGSGMP 2084
            |||:|..||.||..|.::.::||||..||.||||.|:||.:|....   :.|||  ::...:|.|
Zfish   796 NREVLQTLLCFLNDVTSSVEENQMTPMNLAVCLAPSLFHLNIMKND---NLSPRSIQRKYATGRP 857

  Fly  2085 DMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME------------ESKP-LPLEAL 2136
            |.|:|.|..|:.:.|:.||.....::...:|.:|:...||||            :.:| |..|..
Zfish   858 DQKDLNENLAATQGLAHMIAECNHLFEIPQEMVSQSRNSYMEAELLAPSIDELCKKQPQLDEEEE 922

  Fly  2137 GEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIE 2201
            .|..:....|.:|.......::|.::||:||  :...|..:.::::||||||.|||.||.|.|:|
Zfish   923 EEEEEEGTCRSFLDSLIQNLMRESKDKTKGW--VTRSNIDNAELSFKKVGDGTPLRRWRVSAEVE 985

  Fly  2202 GPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDLPRG 2263
            .||..||..::::|..|||:|||.:.::.||.:||:|||.|....   :.||.|||:|:|||.:|
Zfish   986 APPSVVLNRILRERHLWDTDLLQWKLLETLDKQTEVYQYELKSMAPHPSRDFVVLRTWRTDLAKG 1050

  Fly  2264 ACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYGHI 2328
            .||:|..||:|.::..|.| ||.|::.|:||:||||||:||:.|:.|.|:|||:||||||.:||:
Zfish  1051 VCVLVSVSIEHEESPHLAG-VRAVLMESQYLLEPCGSGKSRLTHICRADLKGKSPEWYNKTFGHV 1114

  Fly  2329 CSHYLSRIRLAFKHV-ADGPESKV 2351
            |:....|||.:|:.: .:|||:|:
Zfish  1115 CASEAIRIRNSFQTLDPEGPETKI 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	35/58 (60%)
		RhoGAP_DLC1	1893..2116	CDD:239840	106/224 (47%)
		SRPBCC	2148..2343	CDD:301327	91/197 (46%)
stard13a	XP_683100.5	SAM_DLC2	82..145	CDD:188991	39/62 (63%)
		SAM	86..145	CDD:197735	35/58 (60%)
		RhoGAP_DLC1	671..889	CDD:239840	106/224 (47%)
		SRPBCC	929..1129	CDD:301327	92/202 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3074
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I926
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm25015
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.890