DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-c and GMIP

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_057657.2	Gene:	GMIP / 51291	HGNCID:	24852	Length:	970	Species:	Homo sapiens

Alignment Length:	690	Identity:	141/690 - (20%)
Similarity:	242/690 - (35%)	Gaps:	225/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1527 SKAGGIPNDG---SSLGEGSDSGRLRRSGSERIKDQAKALLRRVES-----IKSRRRKRQNRE-- 1581
            :::.|.|.|.   :|.|......|.|||     :::|:|..:..|:     ::....::|:.|
Human   229 ARSQGSPEDSAPQASPGPSKQQERRRRS-----REEAQAKAQEAEALYQACVREANARQQDLEIA 288

  Fly  1582 ---------NVVISGPTVL---DLSQFGQRSSL--RKPDAVYS-----TPPSPS--------ALS 1619
                     .:|..|..||   .||.||.|.:.  |.|.|..:     .|..|.        ||.
Human   289 KQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRALR 353

  Fly  1620 PMHTFPKAPFFGNDLKVPSHSDNFLSPNRSSPKRTPTTPRSMRTSPLHF---FSSPMSQLKEGKS 1681
            |....|..|.|.....:|                      |:.:|||..   .|.|:..    :.
Human   354 PEAPPPPPPAFSFQEFLP----------------------SLNSSPLDIRKKLSGPLPP----RL 392

  Fly  1682 DDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRT------GKVDDIGAHSDSECHQGRKLLIKDA 1740
            |::|:.....::..||.:            .|.|      ..||.:|..|:|     |.|   |:
Human   393 DENSAEPGPWEDPGTGWR------------WQGTPGPTPGSDVDSVGGGSES-----RSL---DS 437

  Fly  1741 NSNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSS-SFRSRSTSRKEAKNDEDTAGATTNG-GSKRQ 1803
            .:::.....::|.:..|          .|..|| .|..|         |.|......|| ||
Human   438 PTSSPGAGTRQLVKASS----------TGTESSDDFEER---------DPDLGDGLENGLGS--- 480

  Fly  1804 PVVRW--------HSFQMEERP----------------NMIFRKCFSKKIEPLQEDAGGMPFAAM 1844
            |..:|        |..:....|                ...|..|..:.:|
Human   481 PFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMVSGTECEECFLTCHKRCLE-------------- 531

  Fly  1845 SAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSG 1909
                       .|:.|.||  |..|:                :.|      :|||..|.:.:...
Human   532 -----------TLLILCGH--RRLPA----------------RTP------LFGVDFLQLPRDFP 561

  Fly  1910 QTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADM 1974
            :.:|..|......::..|||..||:|.||.:.|:.:|.:..|...:..|...    ...:||:.:
Human   562 EEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSG----NSPHDVSSV 622

  Fly  1975 LKQYFRELPESLLTTKMSETFVAIFQHL------------PAEVRLDAVQCAVLLLPDENREILY 2027
            ||::.:||.|.::...:.:.|:::.:.|            |:...:.:::..::.|||.|...|.
Human   623 LKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPDSNYNTLR 687

  Fly  2028 VLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPRRKGKGSGMPDMKELAEA 2092
            .|:..|..|||...:|:|::||||:....::...  ..|..:.||.|           :..|.::
Human   688 HLVAHLFRVAARFMENKMSANNLGIVFGPTLLRP--PDGPRAASAIP-----------VTCLLDS 739

  Fly  2093 KASHECLSFMIEHYKQIYTAAKEKLSKCNFSYMEESKPLP 2132
            ....:.:.|:|.||:||:  ..::|.:......::|.|.|
Human   740 GHQAQLVEFLIVHYEQIF--GMDELPQATEPPPQDSSPAP 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	55/234 (24%)
		SRPBCC	2148..2343	CDD:301327
GMIP	NP_057657.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..76
		BAR	93..164	CDD:325158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..263		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..478		28/143 (20%)
		C1	492..537	CDD:197519	6/69 (9%)
		RhoGAP_GMIP_PARG1	549..752	CDD:239843	51/219 (23%)
		Marek_A	760..>874	CDD:332932	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..878		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940