Protein Alignment cv-c and Dlc1

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_001181869.1
• Gene: Dlc1 / 50768
• MGIID: 1354949
• Length: 1543
• Species: Mus musculus
• Alignment Length: 1715
• Identity: 486/1715 - (28%)
• Similarity: 729/1715 - (42%)
• Gaps: 505/1715 - (29%)

  Fly   838 VLKPEKHATIPLQSFYLDCGRNEASPATKSNVAYMRTLSAPNGG--------FASGGGGGAARGS 894
            :|.|::|             ..::..:.|...::|:|||.....        .|.......|.||
Mouse   127 ILTPQRH-------------ERDSQDSVKGAGSFMKTLSTMQSSQDSHNTWRMAGKADMSPAEGS 178

  Fly   895 GAPALPPQSQRKSLA-CPPLNGQADTITPTP-------------ATHKLTNFQSALKIEEMAAAK 945
            | .....::..|||. |.  |..||.....|             .|.|.....|::.||::
Mouse   179 G-ERKDVEAINKSLGLCK--NTSADETKDVPIGNTFQSLNTEDDVTPKTLLLDSSVLIEDV---- 236

  Fly   946 GTAMATGESQLATTIEDLKSRRQRQLSGGDMET----MLASQPMSMP--KRVGINHAVLTSRNAI 1004
                 |.|:||..:....:..|:......|.|.    :|....::.|  .| |:.......|:::
Mouse   237 -----TPETQLLDSAVITQQCRKSDFPKDDQENNRHHVLEEDVLAAPYVDR-GLPLLKADCRSSL 295

  Fly  1005 TPPPASASSASQSAASVHSAKGSSSAGTTPGYLVDVTKKGSTSTIWTSEESILRSVGAVDEDNNS 1069
            ..||              |..|..||                                   :|:
Mouse   296 LQPP--------------SCPGGMSA-----------------------------------END- 310

  Fly  1070 TSSSSACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHHHHHHHRK 1134
                                  |:.||.....|:|.:|.:          :...:|..|
Mouse   311 ----------------------LEKSGFSEYQNKSTLGVS----------REDGMQCLH------ 337

  Fly  1135 CTGSAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLDEEKDKMS 1199
            ..|.....|:|.:...|||.|..:.....:..|..||.::..            |.||:
Mouse   338 LRGPVTTQETVDNQVRLRKRKETREDRDRTRLDSMVLLIMKL------------DQLDQ------ 384

  Fly  1200 KSQDYDEIWDCDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHYHSPQPLV 1264
                     |.:.....|||.|      :||..|||                      |.|
Mouse   385 ---------DIENALSTASSPS------STPTNLRR----------------------HVP---- 408

  Fly  1265 HPRKVLPIHHHALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASLHSGLGDS 1329
                          ..|.|.          :|.....|....|::...|...|||..     |.:
Mouse   409 --------------DLESGS----------ESRTDSMAVNQTQVNLSSESTDPSSTP-----GSN 444

  Fly  1330 GGIQELCTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFP 1394
            .|.:   .|:.:|| .:.|:||                         |||||.|||.|||..|||
Mouse   445 SGTK---PKAMAAP-CVGEKEM-------------------------AEIEAKEACDWLRVTGFP 480

  Fly  1395 QYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESDD 1459
            ||||:|||..||||:..|.::|..|:.|.:::|.|||..||:||.|:|:.|  |...:.::..:|
Mouse   481 QYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEIS--PHRKRSEDSDED 543

  Fly  1460 ENFALSEHWTFQPHIRRWSRIGEMGL----ELPPPGL------------------LSLNVE---- 1498
            |..|:|..||||...:||||:.|..:    :.|.||.                  ||.:.|
Mouse   544 EPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQEVASV 608

  Fly  1499 KTESSSKESSPDRFEEDGAGIT----LVTPGCSKAGGIPNDG--SSLGE----GSDSGRLRRSGS 1553
            ::.||:..|.|......|...|    .|...||....:.||.  |||..    .|.|..::....
Mouse   609 RSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMKGHHE 673

  Fly  1554 ERIKDQAKALLRRVESIKSR-----RRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPP 1613
            :..|.:.::||:|:||:|.:     :.|..::..::||.|.   |.:....:.|::.:.|
Mouse   674 KNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPI---LQEGMDEAKLKQLNCV----- 730

  Fly  1614 SPSALSPMHTFPKAPFFGNDLKVP-----SHSDNFLSPNRSSPKRTP---TTP------RSMRT- 1663
            ..|||:           ||.:.||     |.|::..:.:.||...|.   :||      ||:.|
Mouse   731 EISALN-----------GNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTC 784

  Fly  1664 -----------SPLHFFSSPMSQLKEGKSDDSSSYYSD-------------------------SQ 1692
                       .|  |..|.::.:.|....:..||..|                         |.
Mouse   785 NKRVGMYLEGFDP--FSQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSHGSFCPSG 847

  Fly  1693 ESS----TG-----GKLSLRK------PSKARR---------------------FLQRTG----- 1716
            .||    ||     |.||||:      |.:.:|                     ....:|
Mouse   848 NSSVNWRTGSFHGPGHLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADL 912

  Fly  1717 -------KVDDIGAH--------------------------SDSECHQGRKLLIKDANSNTTEVK 1748
                   ::|||..|                          |.|.|....|.:..|.:.:.....
Mouse   913 ENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPS 977

  Fly  1749 VKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQM 1813
            ....| |.|||..::|               |...| :.|.....:.|.....|   :||||||.
Mouse   978 DLDST-GNSLNEPEEP---------------TDIPE-RRDSGVGASLTRCNRHR---LRWHSFQS 1022

  Fly  1814 EERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWE 1878
            ..||::               ::..:.....|..|:.:::|.:|:.||..:|:|.||::.|::|.
Mouse  1023 SHRPSL---------------NSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWA 1072

  Fly  1879 LPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRI 1943
            :|||:|:||:|||||:.||||||.:.:|||||.||.:::.|.|:|:.:.|||||:|||||.||||
Mouse  1073 VPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRI 1137

  Fly  1944 MKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRL 2008
            ..||:..|..:....    ::.|.|||||||||||||:|||.|:|.|:||||:.|:|::|.:.||
Mouse  1138 QALRQMNESAEDNVN----YEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRL 1198

  Fly  2009 DAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSAS 2073
            .|::.|::||||||||:|..||.||:.|.|..::||||..||.||||.|:||  ::|.... ::|
Mouse  1199 QAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFH--LNTLKRE-NSS 1260

  Fly  2074 PR--RKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEA 2135
            ||  ::.:..|.||.|:|.|..|:.:.|:.||...|::: ...|::|:|..||.| |.|||.|||
Mouse  1261 PRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLF-QVPEEMSRCRNSYTEQELKPLTLEA 1324

  Fly  2136 LG--EGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCST 2198
            ||  ...|..::|.:|.:|.....||.:||.:||.|..:  ....:::||||.:|.||||||.:.
Mouse  1325 LGHLNSDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPT--SEQAELSYKKVSEGPPLRLWRSTI 1387

  Fly  2199 EIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDL 2260
            |:...|:|:|:.::|::..||.:||..:.::.||.:||||||..:...   ..|:.|||:|:|:|
Mouse  1388 EVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNL 1452

  Fly  2261 PRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNY 2325
            |||||.::.||:||.:| |:.| ||..||.|||||||||||:|::.::.|.|::|..||||:|::
Mouse  1453 PRGACALLLTSVDHDRA-PVAG-VRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYSKSF 1515

  Fly  2326 GHICSHYLSRIRLAFKHVADGPESK 2350
            ||:|:..:.:||.:|.:  ...|||
Mouse  1516 GHLCAAEVVKIRDSFSN--QNTESK 1538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	32/58 (55%)
		RhoGAP_DLC1	1893..2116	CDD:239840	108/224 (48%)
		SRPBCC	2148..2343	CDD:472699	86/197 (44%)
Dlc1	NP_001181869.1	SAM_DLC1	468..527	CDD:188990	32/58 (55%)
		RhoGAP_DLC1	1087..1305	CDD:239840	109/225 (48%)
		SRPBCC	1330..1533	CDD:472699	88/208 (42%)