DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-c and Dlc1

DIOPT Version :9

Sequence 1:NP_001097786.1 Gene:cv-c / 41749 FlyBaseID:FBgn0285955 Length:2351 Species:Drosophila melanogaster
Sequence 2:NP_001181869.1 Gene:Dlc1 / 50768 MGIID:1354949 Length:1543 Species:Mus musculus


Alignment Length:1715 Identity:486/1715 - (28%)
Similarity:729/1715 - (42%) Gaps:505/1715 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   838 VLKPEKHATIPLQSFYLDCGRNEASPATKSNVAYMRTLSAPNGG--------FASGGGGGAARGS 894
            :|.|::|             ..::..:.|...::|:|||.....        .|.......|.||
Mouse   127 ILTPQRH-------------ERDSQDSVKGAGSFMKTLSTMQSSQDSHNTWRMAGKADMSPAEGS 178

  Fly   895 GAPALPPQSQRKSLA-CPPLNGQADTITPTP-------------ATHKLTNFQSALKIEEMAAAK 945
            | .....::..|||. |.  |..||.....|             .|.|.....|::.||::    
Mouse   179 G-ERKDVEAINKSLGLCK--NTSADETKDVPIGNTFQSLNTEDDVTPKTLLLDSSVLIEDV---- 236

  Fly   946 GTAMATGESQLATTIEDLKSRRQRQLSGGDMET----MLASQPMSMP--KRVGINHAVLTSRNAI 1004
                 |.|:||..:....:..|:......|.|.    :|....::.|  .| |:.......|:::
Mouse   237 -----TPETQLLDSAVITQQCRKSDFPKDDQENNRHHVLEEDVLAAPYVDR-GLPLLKADCRSSL 295

  Fly  1005 TPPPASASSASQSAASVHSAKGSSSAGTTPGYLVDVTKKGSTSTIWTSEESILRSVGAVDEDNNS 1069
            ..||              |..|..||                                   :|: 
Mouse   296 LQPP--------------SCPGGMSA-----------------------------------END- 310

  Fly  1070 TSSSSACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHHHHHHHRK 1134
                                  |:.||.....|:|.:|.:          :...:|..|      
Mouse   311 ----------------------LEKSGFSEYQNKSTLGVS----------REDGMQCLH------ 337

  Fly  1135 CTGSAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLDEEKDKMS 1199
            ..|.....|:|.:...|||.|..:.....:..|..||.::..            |.||:      
Mouse   338 LRGPVTTQETVDNQVRLRKRKETREDRDRTRLDSMVLLIMKL------------DQLDQ------ 384

  Fly  1200 KSQDYDEIWDCDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHYHSPQPLV 1264
                     |.:.....|||.|      :||..|||                      |.|    
Mouse   385 ---------DIENALSTASSPS------STPTNLRR----------------------HVP---- 408

  Fly  1265 HPRKVLPIHHHALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASLHSGLGDS 1329
                          ..|.|.          :|.....|....|::...|...|||..     |.:
Mouse   409 --------------DLESGS----------ESRTDSMAVNQTQVNLSSESTDPSSTP-----GSN 444

  Fly  1330 GGIQELCTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFP 1394
            .|.:   .|:.:|| .:.|:||                         |||||.|||.|||..|||
Mouse   445 SGTK---PKAMAAP-CVGEKEM-------------------------AEIEAKEACDWLRVTGFP 480

  Fly  1395 QYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESDD 1459
            ||||:|||..||||:..|.::|..|:.|.:::|.|||..||:||.|:|:.|  |...:.::..:|
Mouse   481 QYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEIS--PHRKRSEDSDED 543

  Fly  1460 ENFALSEHWTFQPHIRRWSRIGEMGL----ELPPPGL------------------LSLNVE---- 1498
            |..|:|..||||...:||||:.|..:    :.|.||.                  ||.:.|    
Mouse   544 EPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQEVASV 608

  Fly  1499 KTESSSKESSPDRFEEDGAGIT----LVTPGCSKAGGIPNDG--SSLGE----GSDSGRLRRSGS 1553
            ::.||:..|.|......|...|    .|...||....:.||.  |||..    .|.|..::....
Mouse   609 RSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMKGHHE 673

  Fly  1554 ERIKDQAKALLRRVESIKSR-----RRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPP 1613
            :..|.:.::||:|:||:|.:     :.|..::..::||.|.   |.:....:.|::.:.|     
Mouse   674 KNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPI---LQEGMDEAKLKQLNCV----- 730

  Fly  1614 SPSALSPMHTFPKAPFFGNDLKVP-----SHSDNFLSPNRSSPKRTP---TTP------RSMRT- 1663
            ..|||:           ||.:.||     |.|::..:.:.||...|.   :||      ||:.| 
Mouse   731 EISALN-----------GNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTC 784

  Fly  1664 -----------SPLHFFSSPMSQLKEGKSDDSSSYYSD-------------------------SQ 1692
                       .|  |..|.::.:.|....:..||..|                         |.
Mouse   785 NKRVGMYLEGFDP--FSQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSHGSFCPSG 847

  Fly  1693 ESS----TG-----GKLSLRK------PSKARR---------------------FLQRTG----- 1716
            .||    ||     |.||||:      |.:.:|                     ....:|     
Mouse   848 NSSVNWRTGSFHGPGHLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADL 912

  Fly  1717 -------KVDDIGAH--------------------------SDSECHQGRKLLIKDANSNTTEVK 1748
                   ::|||..|                          |.|.|....|.:..|.:.:.....
Mouse   913 ENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPS 977

  Fly  1749 VKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQM 1813
            ....| |.|||..::|               |...| :.|.....:.|.....|   :||||||.
Mouse   978 DLDST-GNSLNEPEEP---------------TDIPE-RRDSGVGASLTRCNRHR---LRWHSFQS 1022

  Fly  1814 EERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWE 1878
            ..||::               ::..:.....|..|:.:::|.:|:.||..:|:|.||::.|::|.
Mouse  1023 SHRPSL---------------NSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWA 1072

  Fly  1879 LPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRI 1943
            :|||:|:||:|||||:.||||||.:.:|||||.||.:::.|.|:|:.:.|||||:|||||.||||
Mouse  1073 VPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRI 1137

  Fly  1944 MKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRL 2008
            ..||:..|..:....    ::.|.|||||||||||||:|||.|:|.|:||||:.|:|::|.:.||
Mouse  1138 QALRQMNESAEDNVN----YEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRL 1198

  Fly  2009 DAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSAS 2073
            .|::.|::||||||||:|..||.||:.|.|..::||||..||.||||.|:||  ::|.... ::|
Mouse  1199 QAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFH--LNTLKRE-NSS 1260

  Fly  2074 PR--RKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEA 2135
            ||  ::.:..|.||.|:|.|..|:.:.|:.||...|::: ...|::|:|..||.| |.|||.|||
Mouse  1261 PRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLF-QVPEEMSRCRNSYTEQELKPLTLEA 1324

  Fly  2136 LG--EGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCST 2198
            ||  ...|..::|.:|.:|.....||.:||.:||.|..:  ....:::||||.:|.||||||.:.
Mouse  1325 LGHLNSDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPT--SEQAELSYKKVSEGPPLRLWRSTI 1387

  Fly  2199 EIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDL 2260
            |:...|:|:|:.::|::..||.:||..:.::.||.:||||||..:...   ..|:.|||:|:|:|
Mouse  1388 EVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNL 1452

  Fly  2261 PRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNY 2325
            |||||.::.||:||.:| |:.| ||..||.|||||||||||:|::.::.|.|::|..||||:|::
Mouse  1453 PRGACALLLTSVDHDRA-PVAG-VRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYSKSF 1515

  Fly  2326 GHICSHYLSRIRLAFKHVADGPESK 2350
            ||:|:..:.:||.:|.:  ...|||
Mouse  1516 GHLCAAEVVKIRDSFSN--QNTESK 1538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-cNP_001097786.1 SAM_DLC1,2-like 1382..1441 CDD:188937 32/58 (55%)
RhoGAP_DLC1 1893..2116 CDD:239840 108/224 (48%)
SRPBCC 2148..2343 CDD:301327 86/197 (44%)
Dlc1NP_001181869.1 SAM_DLC1 468..527 CDD:188990 32/58 (55%)
RhoGAP_DLC1 1087..1305 CDD:239840 109/225 (48%)
SRPBCC 1330..1533 CDD:387369 88/208 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 199 1.000 Domainoid score I3058
eggNOG 1 0.900 - - E1_KOG2200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4702
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001209
OrthoInspector 1 1.000 - - otm42668
orthoMCL 1 0.900 - - OOG6_103453
Panther 1 1.100 - - LDO PTHR12659
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3060
SonicParanoid 1 1.000 - - X752
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.790

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