Protein Alignment cv-c and ARHGAP40

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_001157903.2
• Gene: ARHGAP40 / 343578
• HGNCID: 16226
• Length: 675
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 132/573 - (23%)
• Similarity: 224/573 - (39%)
• Gaps: 136/573 - (23%)

  Fly  1613 PSPSALSPMHTFPKA------------------PFFGNDLKVPSHSDNFLSPNRSSPKRTPTTPR 1659
            |.|.| ||....|:|                  |..|...::|  ..|.|   |..|..:.....
Human    17 PGPLA-SPCPRIPRARIARRCAQRWADLGCSSGPSSGRMDQLP--QKNLL---RLHPAGSAGCST 75

  Fly  1660 SMRTSPLHFFSSPMSQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSKAR-RFLQRTGKVDDIGA 1723
            .:.:|.:..|...:.|:::  .|:.      .:|.|.|.:..|.:..:|. ::||.||....:|.
Human    76 GVESSSMDGFWMEVEQIQQ--RDEL------REEDSGGNEGQLPEEGEAESQWLQDTGLSGLLGG 132

  Fly  1724 HSDSECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKN- 1787
            ......||  :||     |..|:.:|..:.|           :.|.:..|..|...|..::.::
Human   133 LGLDGDHQ--ELL-----STLTQTQVAAVCR-----------RLDIYARSVRRQHKTPVRDVRDV 179

  Fly  1788 --------------DEDTAGATTNGGSKRQPVV-----------RWHSFQME------------- 1814
                          |....||..:.|:.:.|..           |..:|.|:
Human   180 FGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSAYSEQAAVLLQR 244

  Fly  1815 ERPN----MIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGW 1875
            .||:    ..:.||...|....:...|......:|...::.:..|||:.||.    .|..
Human   245 SRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIELTA----LCDI----- 300

  Fly  1876 NWELPKFIKKIKMPDYK--DKKVFGVPLLMILQRSGQTL-----PLAVRAAFRWLQLNALDQVGI 1933
               |...:|:.|...:|  :.::|||||..:|:...:.|     ||.::|....|:...||..||
Human   301 ---LGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 362

  Fly  1934 FRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAY--DVADMLKQYFRELPESLLTTKMSETFV 1996
            .|..|.::|:..|.:::| .|..|   .:|...:.:  |.:|:||::.|:||..|||.:....|
Human   363 LRVPGSQARVKGLEQKLE-RDFYA---GLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF- 422

  Fly  1997 AIFQHLP-AEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFH 2060
            |:..::| .:.||..:...:|:||:.||..|..|||||..|.|..|.|:||..|:...:|.::|
Human   423 AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF- 486

  Fly  2061 SSISTGSASVSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAA 2113
                          ..:|:...:|..||...|:.:.|.:..|:.:...::|.|
Human   487 --------------LHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVA 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	67/229 (29%)
		SRPBCC	2148..2343	CDD:472699
ARHGAP40	NP_001157903.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..118		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..218		5/30 (17%)
		RhoGAP	320..533	CDD:470621	67/226 (30%)