Protein Alignment cv-c and Stard8

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_038955618.1
• Gene: Stard8 / 312113
• RGDID: 1560770
• Length: 1136
• Species: Rattus norvegicus
• Alignment Length: 1216
• Identity: 377/1216 - (31%)
• Similarity: 570/1216 - (46%)
• Gaps: 261/1216 - (21%)

  Fly  1311 FVELPSPSSASLHS---GLGDSGGIQELCTKSNSAPMLL---------KEREMSRRFDNFEAQHL 1363
            |..|.|.||.|.|:   |.|..     ||   ...|..|         .|||      .|.:..|
  Rat     7 FSNLDSCSSTSTHAHSKGCGPC-----LC---RHYPCCLGFLSPSPSWNERE------TFLSWGL 57

  Fly  1364 TLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLY 1428
            .:   .|...::..|.||.:||:||||.|||||||::|:..||:|:.:|.||::.|:.|.|.:|.
  Rat    58 EV---GSPRHKWCLEAEAKKACEWLRATGFPQYAQLFEEGVFPLDIGSVKKDYSFLDQDSLGALC 119

  Fly  1429 RRLCVLNRCATMRLDQSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPP---- 1489
            |||..||.||:|:|:...:  ..|..:..::|...:|.||.|:...:..|..|...|..||
  Rat   120 RRLMTLNNCASMKLEVHFR--CKQDDDSEEEEQCTISSHWAFEQESKCGSLTGSSALLAPPSPSL 182

  Fly  1490 PGLLSLNVEKTESS-------SKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGS----SLGEGS 1543
            ||..|.....||.|       |...||     :.|.:.|:       |.:|:..:    |..:|.
  Rat   183 PGTSSCESVLTELSAASLPAISVSLSP-----ESADLPLL-------GHVPSPSNQPFLSPTQGQ 235

  Fly  1544 DSGRLRRSGSERIKDQ-AKALLRRVESIKSRRRKRQNRE-------------------------- 1581
            :..:      :::|.. :::.|:.:||:: |:.|..:|:
  Rat   236 EGSQ------DKVKKHYSRSFLKHLESLR-RKEKGDSRQTEPEQRLATSEKATKASSFRTCRGLL 293

  Fly  1582 --------NVVISGPTVLD-----------LSQFGQRSSLRKPDAVYSTP--PSPSALSPMHTFP 1625
                    |.|.:.|.|.|           ::.|......|:.|.:...|  ..|.      |||
  Rat   294 SVGFHRAKNRVTTSPRVRDGETQKTWEAWPVATFRHPQPNRRHDCLVHVPRDHKPG------TFP 352

  Fly  1626 KAPFFGNDLKVPSHSDNFL--SPN--------RSSPKRTPTTPRSMRTSPLHFFSSPMSQLKEGK 1680
            ::  ...:...|..|.:..  .||        |.|...|.:...:....|..:.:.|:....|.:
  Rat   353 RS--LSIESLCPDDSRHLADWQPNRCWGYEGRRGSCGSTGSHASTYDNLPELYPAEPIQAEAEDE 415

  Fly  1681 SDDSSSYYS---DSQESSTGGKLSLR----------------KPSKARRFLQRTGKV-------- 1718
            .::....|:   |..|...|  |..|                |..:.....:.|..|
  Rat   416 DEEGEGSYAHLDDILEHVWG--LQQRVELWSQAMYPDLRPGDKEEEEEEEEEATSSVEIATAEVE 478

  Fly  1719 --DDIGAHSDSECHQGRKLLIK--------------------------------DANSNTTEVKV 1749
              |:..|.::|:.|:|....:|                                ||||....:..
  Rat   479 GQDEALAQAESQVHRGFPTEVKEEVPLIVLDQAPTVVEPLVQAEAPAQAQHPEQDANSAAEPISA 543

  Fly  1750 KKLT--RGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTN----------GGSKR 1802
            ..|:  .|.|::       .....||...|...|..||...:..||...:          |.|..
  Rat   544 SSLSVEEGHSIS-------DTAVSSSELDSSGNSVNEADVADALAGPNASVPRERRDSGVGASLT 601

  Fly  1803 QPV--VRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHME 1865
            :|.  :||||||...||::               ::..:......|||:.::.|.:|:.|||.||
  Rat   602 RPCRKLRWHSFQNSHRPSL---------------NSESLEINRQFAGQINLLHKGSLLRLTGFME 651

  Fly  1866 RYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQ 1930
            :|...|:..|.|.:|||:|:.|.|||:...|||||.|:.:||:||.||.:::.|.|:|:...|||
  Rat   652 KYTVPHKQAWVWSMPKFMKRNKTPDYRGHHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQ 716

  Fly  1931 VGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETF 1995
            ||||||||.||||..||:..|.:.... |   ::.|.||||||:||||||:|||.:.|:|::.||
  Rat   717 VGIFRKSGVKSRIQSLRQMNETSPDNV-C---YEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTF 777

  Fly  1996 VAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFH 2060
            :.|:|.||.|..|.|.|.|.|||||||||:|..||.||:.: |::::||||:.||.||||.||||
  Rat   778 LQIYQLLPKEQWLAAAQAATLLLPDENREVLQTLLYFLSDI-ASAEENQMTAGNLAVCLAPSIFH 841

  Fly  2061 SSISTGSASVSASPRRKGKGS--GMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSK-C-N 2121
            .::|...   |.|||.|.|.|  |.|..::|:|..|:.:.||.||...|:::...::.:.: | :
  Rat   842 LNVSKKD---SPSPRIKSKRSLVGRPGPRDLSENMAATQGLSHMISDCKKLFQVPQDMVVQLCGS 903

  Fly  2122 FSYMEESKPLP-------LEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVD 2179
            :|..|.:.|.|       .:|.|..:..     |:.|.....:::..|:.:||  .|.......:
  Rat   904 YSAAELTPPGPALAELRQAQAAGVSLSL-----YMEESVQELLRDAAERFKGW--TNVPGPQHTE 961

  Fly  2180 IAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDG 2244
            :|.:|..||||||:|:.|||:..||..||..|:::||.||.:||:.|.::.|....|:|.|..|.
  Rat   962 LACRKAPDGHPLRMWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDS 1026

  Fly  2245 QL---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVM 2306
            ..   ..||.|||.|::|||||.|::|..|:|..:..|..| ||.::|.|:||:||||.||||:.
  Rat  1027 MAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESG-VRALMLTSQYLMEPCGLGRSRLT 1090

  Fly  2307 HLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHV-ADGPESKV 2351
            |:.|.|::|::|:||||.:||:|:..:::||.:|..: |.|||:|:
  Rat  1091 HICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	31/58 (53%)
		RhoGAP_DLC1	1893..2116	CDD:239840	110/224 (49%)
		SRPBCC	2148..2343	CDD:472699	81/197 (41%)
Stard8	XP_038955618.1	SAM_DLC1,2-like	73..132	CDD:188937	31/58 (53%)
		RhoGAP	682..896	CDD:470621	110/221 (50%)
		SRPBCC	923..1127	CDD:472699	83/211 (39%)