Protein Alignment cv-c and Arhgap18

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_001164046.1
• Gene: Arhgap18 / 293947
• RGDID: 1305053
• Length: 665
• Species: Rattus norvegicus
• Alignment Length: 872
• Identity: 178/872 - (20%)
• Similarity: 318/872 - (36%)
• Gaps: 281/872 - (32%)

  Fly  1439 TMRLDQSHK--PQTPQQKEESDD--ENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEK 1499
            ||..:.|.|  .:.|..:..|.|  :..::..:||...:|:|.:.                |.::
  Rat    45 TMNPESSTKLSERPPFDRSSSQDSLDEVSMEAYWTELENIKRSTE----------------NCQE 93

  Fly  1500 TESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRLRRSGSERI-------K 1557
            .:.:.....||..|.:...:        |..|:.|   ..||.:|..:      |.|       :
  Rat    94 GQEAIVVKEPDEGELEEEWL--------KEAGLSN---LFGESADDSQ------ESIVFLSTLTR 141

  Fly  1558 DQAKALLRRVESIKSRRRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMH 1622
            .||.|:.:|||::....||:..:.::    |.|.|:  |.|:...::
  Rat   142 TQAAAVQKRVETVSQTLRKKSKQYHI----PDVRDI--FAQQREAQE------------------ 182

  Fly  1623 TFPKAPFFGNDLKVPSHSDNFLSPNRSSPKRTPTTPRSMRTSPLHFFSSPMSQLKEGKSDDSSSY 1687
                        |.|..||                .||:||:         ....:||.|..||.
  Rat   183 ------------KSPDDSD----------------LRSVRTN---------ENEDQGKDDQPSSG 210

  Fly  1688 YSDSQESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVKVKKL 1752
            ..|::|...      |.|             :||.|   ||.....::...:...|..|:..:::
  Rat   211 AVDNKEPIP------RVP-------------EDIPA---SETDINLEVSFAEQAVNQKELSKERM 253

  Fly  1753 --TRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEE 1815
              |||...:|            .|||.          .:|..|.|..|               :.
  Rat   254 QKTRGNDASL------------PSFRL----------PKDKTGTTRIG---------------DL 281

  Fly  1816 RPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELP 1880
            .|..:.:.|:                       |.:|...||..:.|              .||
  Rat   282 APQDMKKVCY-----------------------LSLIELTALYDVLG--------------VEL- 308

  Fly  1881 KFIKKIKMPDYKDKKVFGVPLLMILQRS-----GQTLPLAVRAAFRWLQLNALDQVGIFRKSGGK 1940
            |..|.:|:.. :|..:||:||.::|::.     |..:||..:.....::..:|:..|:.|..|..
  Rat   309 KQQKAVKIKT-RDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISCIEEGSLETEGLLRIPGAA 372

  Fly  1941 SRIMKLREQIEVT--DSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLP 2003
            .|:..|.:::|..  :.|.....|    :.:|.|.:||.:.||||:.||:|:..:.|.|: |:||
  Rat   373 MRVKNLCQELEAKFYEGTFNWESV----KQHDAASLLKLFLRELPQPLLSTEYLKAFQAV-QNLP 432

  Fly  2004 A-EVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIF--HSSIST 2065
            . :.:|.|:...|:||||.||:.|..|||||..|..|.::|:||:.|:.:.:|.::|  |:
  Rat   433 TKKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAVNVAMVMAPNLFMCHA---- 493

  Fly  2066 GSASVSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEE 2127
                         .|....:.:|...|..:...:..:|.:.|.::|..|   .::.|.|.::.::
  Rat   494 -------------LGLKSSEHREFEMAAGTANTMHLLIRYQKLLWTIPKFIVNQVRKHNTAHQKK 545

  Fly  2128 SKPLPLEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLR 2192
            .: ..::.|.:.|.:...:....:..:    .|.:..:|...:.:.:.|.|.:|.:
  Rat   546 ER-RAMKKLLKKMAYDREKHEKQDRAA----NGADVPQGVIRVQAPHLSKVSMAIQ--------- 596

  Fly  2193 LWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQLTTDFCVLRSWQ 2257
                .|| |....:||...:.|.:.      ..||:||    .|::.|.:.|.:........::.
  Rat   597 ----LTE-ELKASDVLARFLSQESG------VAQTLKK----GEVFLYEIGGNIGERCLDDDTYM 646

  Fly  2258 TDL----PRGACVIVETSIDHAKAKPL 2280
            .||    |....||        |:||:
  Rat   647 KDLYHLNPNAEWVI--------KSKPV 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	1/1 (100%)
		RhoGAP_DLC1	1893..2116	CDD:239840	65/235 (28%)
		SRPBCC	2148..2343	CDD:472699	26/137 (19%)
Arhgap18	NP_001164046.1	RhoGAP_ARHGAP18	323..536	CDD:239856	64/234 (27%)