DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-c and Stard13

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001156965.1	Gene:	Stard13 / 243362	MGIID:	2385331	Length:	1132	Species:	Mus musculus

Alignment Length:	1202	Identity:	401/1202 - (33%)
Similarity:	594/1202 - (49%)	Gaps:	280/1202 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1343 PMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLA-----EIEAVEACKWLRAAGFPQYAQMYED 1402
            |:..:.:||..|||. .|:....|.||..:..:|.     ||||.|||.||||||||||||:|||
Mouse    18 PLTPESQEMYLRFDQ-TARRSPYRMSRILARHHLVTKIQQEIEAKEACDWLRAAGFPQYAQLYED 81

  Fly  1403 HQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQK--EESDDENFALS 1465
            .||||::..|.|||..||.|.::.|.|||..||:||:||||.:.     |:|  ::||:|:..:|
Mouse    82 SQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMRLDVNF-----QRKKGDDSDEEDLCIS 141

  Fly  1466 EHWTFQPHIRRWSRIGEMG---------------------------LELPPPGLLSLNVEKTESS 1503
            ..||||...|||||:.::.                           .:|..|.:.|::.|.:..|
Mouse   142 NKWTFQRTSRRWSRVDDLHTLFPVADRNGSPGGPRMRNTASSESVLTDLSEPEVCSIHSESSGGS 206

  Fly  1504 SKESSPDRFEEDGA---GITLVTPGCSKAGGIPNDGSSLGEGSDSGRLRRS----GSERIKDQAK 1561
            ...|.......|..   ..|||:             |||.:.:..| |.:|    ..:..:.:||
Mouse   207 DSRSQSGHHSADSTHALEATLVS-------------SSLPQSTREG-LNQSFHPKNEKPTRTRAK 257

  Fly  1562 ALLRRVESIKSR----RRKRQNRE-NVVISGPTVL-----------------DL----------- 1593
            :.|:|:::::.:    |.|...|. .:|||.|.:.                 ||
Mouse   258 SFLKRMDTLRVKGALGRHKGPGRTGGLVISRPVLQQEPESFKTMQCVQIPNGDLQTSPPAACRKG 322

  Fly  1594 -----SQFGQRSSLRKPDAVYSTP------------------------------PSPSALSPMH- 1622
                 ...|:.|.|.....| |||                              |..|..:.||
Mouse   323 LPCSSKSSGESSPLENSSTV-STPCMKERKCHHEANKRGGMYLEDLDVLAGTALPDTSDQNHMHG 386

  Fly  1623 ------------------TFPKAPFFGNDLKV----PSHSDNFLS-------------PNRSSPK 1652
                              |||||      |.:    |:.:.|.::             |....|:
Mouse   387 FHSQENLVVHIPKDHKPGTFPKA------LSIESLSPTDNSNGVNWRTGSISLGRQQGPGMREPR 445

  Fly  1653 RTPTTPRSMRTSPLHFFSSPMSQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGK 1717
            ...:..|:.|.|  .:.:.|.|.|                .:|||..|.|.|..       ...:
Mouse   446 LMSSCHRASRVS--IYDNVPSSHL----------------YASTGDLLDLEKDG-------LLPQ 485

  Fly  1718 VDDIGAHSD---SECHQGRKLLIKDANSNTTEVKVKKLT------------RGGSLNLGK-DPKK 1766
            :|||..|.:   .......|.::.:..|::|......|:            .|.|::.|: .|..
Mouse   486 LDDILQHVNGIQEVVDDWSKNILPELQSHSTLAGDPGLSPFPSPNQVTLDFEGNSVSEGRTTPSD 550

  Fly  1767 RDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEP 1831
            .:..|:|...|.:|..:|.:  :...||:....::|   :||.|||:..:|
Mouse   551 VERDRTSLNESEATGVRERR--DSGVGASLTRPNRR---LRWSSFQLSHQP-------------- 596

  Fly  1832 LQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGW-------------------NW 1877
             |........::.:|.||.::::.:|:.||..||:|..|::.||                   :.
Mouse   597 -QPSPATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWTCLSAQSAPGALHDLVSVNSR 660

  Fly  1878 ELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSR 1942
            .:|||:|:||.|||:||.||||||::.:||:||.||.:::.|.|:|:.|.|||||:|||||.|||
Mouse   661 SVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSR 725

  Fly  1943 IMKLREQIE-VTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEV 2006
            |..||:..| ..|:.:     ::.|.|||||||:||:||:|||.|.|.|:||||:.|:|::|.|.
Mouse   726 IHALRQMNENFPDNVS-----YEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQ 785

  Fly  2007 RLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVS 2071
            ||.|||.|:|||.|||||.|..||.||..|.....:||||..||.||||.|:||.::    ....
Mouse   786 RLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFHLNL----LKKE 846

  Fly  2072 ASPR--RKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYMEESKPLP-L 2133
            :||:  :|...:|.||.|:|.|..|:.:.|:.||....:::....|.:::...||:|....:| |
Mouse   847 SSPKVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRDSYLEAEIHVPSL 911

  Fly  2134 EALG-----EGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRL 2193
            |.||     .|..||.   ||........||.:||.:||.:.:|  ..:.|:|:|||||||||:|
Mouse   912 EDLGAQLAESGATFHT---YLEHLVQGLQKEAKEKFKGWVTCSS--PDNTDLAFKKVGDGHPLKL 971

  Fly  2194 WRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRS 2255
            |:.|.|:|.||..||..|:::|..||.:.:|.:.|::||.:||||||.|:..:   :.||.|||:
Mouse   972 WKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVERLDKQTEIYQYVLNSMVPHPSRDFLVLRT 1036

  Fly  2256 WQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEW 2320
            |:||||:|.|.:|..|:::.:|: |.|.||.||:.|:|||||||||:||:.|:.|:|:||.:|||
Mouse  1037 WKTDLPKGMCTLVSLSVEYEEAQ-LMGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEW 1100

  Fly  2321 YNKNYGHICSHYLSRIRLAFKH-VADGPESKV 2351
            |:|.:||:|:..::|||.:|:. ||:|||:|:
Mouse  1101 YSKGFGHLCAAEVTRIRNSFQPLVAEGPETKI 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	37/58 (64%)
		RhoGAP_DLC1	1893..2116	CDD:239840	108/225 (48%)
		SRPBCC	2148..2343	CDD:301327	94/198 (47%)
Stard13	NP_001156965.1	SAM_DLC2	57..120	CDD:188991	41/62 (66%)
		SAM	61..120	CDD:197735	37/58 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..218		6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..256		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..343		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..443		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..578		13/65 (20%)
		RhoGAP_DLC1	676..893	CDD:239840	108/225 (48%)
		SRPBCC	920..1123	CDD:301327	97/208 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3058
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm42668
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.840