Protein Alignment cv-c and Stard8

DIOPT Version :9

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_006528061.1
• Gene: Stard8 / 236920
• MGIID: 2448556
• Length: 1099
• Species: Mus musculus
• Alignment Length: 1150
• Identity: 352/1150 - (30%)
• Similarity: 548/1150 - (47%)
• Gaps: 253/1150 - (22%)

  Fly  1378 EIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRL 1442
            |.||.:||:||||.||.||||::|:..||:|:.:|.||::.|:.|.|.:|.|||..||.||:|:|
Mouse    27 EAEAKKACEWLRATGFSQYAQLFEEGVFPLDIGSVKKDYSFLDQDSLGALCRRLMTLNNCASMKL 91

  Fly  1443 DQSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPP-PGLL----------SLN 1496
            :...  |..|..:..::|...:|.||.|:...:..|.:|...|..|| |.||          .|:
Mouse    92 EVHF--QCKQDDDSEEEEQCTISSHWAFEQESKCGSLMGSSALLAPPSPSLLGTSSCESVLTELS 154

  Fly  1497 VEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGI-PNDGSSLGEGSDSGRLRRSGSERIKDQ- 1559
            .....:.|...||:..::...|:   .|..|....: |..|.   |||         .:::|..
Mouse   155 AASLPAISASLSPESADQPLLGL---VPSPSNQPFLSPPQGQ---EGS---------QDKVKKHY 204

  Fly  1560 AKALLRRVESIKSRRRKRQNRE----------------------------------NVVISGPTV 1590
            :::.|:.:||:: |:.|..:|:                                  |.|.:...|
Mouse   205 SRSFLKHLESLR-RKEKGDSRQTEPEQCLATSEKATKASSFRTCRGFLSAGFHRAKNRVTTSARV 268

  Fly  1591 LD-----------LSQFGQRSSLRKPDAVYSTPPSPSALSPMH---TFPKA-------PFFGNDL 1634
            .|           ::.|.....:|:.|.:...|..       |   |||::       |..|..|
Mouse   269 RDGETQKAWEAWPVATFRHPQPIRRRDYLVHVPGD-------HKPGTFPRSLSIESLCPDEGRHL 326

  Fly  1635 -------------------KVPSHSDNFLSPNRSSPKRTPTTPRSMRTSP--------------- 1665
                               ...||:..:    .:.|:..|..|.......
Mouse   327 ADWQSSRCWGYEGRRGSCGSTGSHASTY----DNLPELYPAEPIQAEAEAEAEEGEGSYAHLDDI 387

  Fly  1666 ----------LHFFSSPM-SQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGKVD 1719
                      :..:|..| ..|:.|..::......:.:|:::..:::.         ::..|:.:
Mouse   388 LEHVWGLQQRVELWSQTMYPDLRPGDKEEEEEEEEEEEEATSSVEVAT---------VEVEGQDE 443

  Fly  1720 DIGAHSDSECHQGRKLLIK----------------------------------DANSNTTEVKVK 1750
            |: |.::|:.|:|....:|                                  :|||....:...
Mouse   444 DL-AQAESQAHRGFPTQVKEEVPLIVLDQAPNVVEPLVQAEAEAPAQAQDLEQEANSTAEPISAS 507

  Fly  1751 KLT--RGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTN----------GGSKRQ 1803
            .|:  .|.|::       .....||...|...|..||...:..||...:          |.|..:
Mouse   508 SLSVEEGHSIS-------DTAVSSSELDSSGNSMNEADAADAPAGLQASVPRERRDSGVGASLTR 565

  Fly  1804 PV--VRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMER 1866
            |.  :||||||...||::               ::..:......|||:.::.|.:|:.|||.||:
Mouse   566 PCRKLRWHSFQNSHRPSL---------------NSESLEINRQFAGQINLLHKGSLLRLTGFMEK 615

  Fly  1867 YCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQV 1931
            |...|:..|.|.:|||:|:.|.|||:...|||||.|:.:||:||.||.:::.|.|:|:...||||
Mouse   616 YTVPHKQAWVWSMPKFMKRNKTPDYRGHHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQV 680

  Fly  1932 GIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFV 1996
            |||||||.||||..||:..|.:.... |   ::.|.||||||:||||||:|||.:.|:|::.||:
Mouse   681 GIFRKSGVKSRIQSLRQMNENSPDNV-C---YEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFL 741

  Fly  1997 AIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHS 2061
            .|:|.||.|..|.|.|.|.|||||||||:|..||.||:.: |::::||||:.||.||||.||||.
Mouse   742 QIYQLLPKEQWLAAAQAATLLLPDENREVLQTLLYFLSDI-ASAEENQMTAGNLAVCLAPSIFHL 805

  Fly  2062 SISTGSASVSASPRRKGKGS--GMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSK-C-NF 2122
            ::|...   |:|||.|.|.|  |.|..::|:|..|:.:.||.||...|:::...::.:.: | ::
Mouse   806 NVSKKD---SSSPRIKSKRSLVGRPGPRDLSENMAATQGLSHMISDCKKLFQVPQDMVVQLCGSY 867

  Fly  2123 SYMEESKPLP-------LEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDI 2180
            |..|.|.|.|       .:|.|..:..     |:.|.....:::..|:.:||  .|.......::
Mouse   868 SAAELSPPGPALAELRQAQAAGVSLSL-----YMEESVQELLRDAAERFKGW--TNVPGPQHTEL 925

  Fly  2181 AYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQ 2245
            |.:|..||||||:|:.|||:..||..||..|:::||.||.:||:.|.::.|....|:|.|..|..
Mouse   926 ACRKAPDGHPLRMWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSM 990

  Fly  2246 L---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMH 2307
            .   ..||.|||.|::|||||.|::|..|:|..:..|..| ||.::|.|:||:||||.||||:.|
Mouse   991 APHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESG-VRALMLTSQYLMEPCGLGRSRLTH 1054

  Fly  2308 LARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHV-ADGPESKV 2351
            :.|.|::|::|:||||.:||:|:..:::||.:|..: |.|||:|:
Mouse  1055 ICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	30/58 (52%)
		RhoGAP_DLC1	1893..2116	CDD:239840	110/224 (49%)
		SRPBCC	2148..2343	CDD:301327	81/197 (41%)
Stard8	XP_006528061.1	SAM_DLC1,2-like	31..90	CDD:188937	30/58 (52%)
		RhoGAP	645..859	CDD:383032	110/221 (50%)
		SRPBCC	886..1090	CDD:387369	83/211 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3058
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm42668
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810