Protein Alignment cv-c and gei-1

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_497694.3
• Gene: gei-1 / 175436
• WormBaseID: WBGene00001559
• Length: 1510
• Species: Caenorhabditis elegans
• Alignment Length: 1742
• Identity: 431/1742 - (24%)
• Similarity: 671/1742 - (38%)
• Gaps: 499/1742 - (28%)

  Fly   831 QQQQNGLVLKPEKHATIPLQSFYLDCGRNEAS----------------PATKSNVAYMRTLSAPN 879
            :||:..||::|:       .|..|..|:|::|                |..:...|..|.:..
 Worm    47 KQQRKSLVIEPD-------ISLILAAGQNQSSSSDDDDTKVQIDSNTLPQNRRKYAGRRNMKK-- 102

  Fly   880 GGFASGGGGGAARGSGAPALPPQSQRKSLACPPLNGQADTITPTPATHKLTNFQSALKIEEMAAA 944
             .|.|.................|...|||:...|||  |.|          :|.:...:::..
 Worm   103 -RFYSTSNLKGNEDENDENSSKQIGTKSLSVRDLNG--DNI----------DFNNRDSVKKWT-- 152

  Fly   945 KGTAMATGESQLATTIEDLKSRRQRQLSGGDME-TMLASQPMSMPKRVGINHAVLTSRNAITPPP 1008
                     ||:...:|.:.|.|:     |.|| |...:.|   |..:.||.|     ..:.||.
 Worm   153 ---------SQIFAELESIPSSRR-----GSMEVTRAMTNP---PPELMINLA-----PTLAPPS 195

  Fly  1009 A----------SASSASQSAASVHSAKGSSSAGTTPGYLVD-VTKKGSTSTIWTSEESILRSVGA 1062
            .          ...:..|..|.|.|.:........|.:|.| :|...|.|....|..|
 Worm   196 PMKRKRFPVFDEQEAGFQPIAPVPSPRRQQEDVVGPTFLRDLLTASCSRSPCSESNYS------- 253

  Fly  1063 VDEDNNSTSSSSACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHH 1127
               |..:||.::..::|:                                :..|..|    |::.
 Worm   254 ---DRLATSDTATTQKAS--------------------------------RASSFEW----LENS 279

  Fly  1128 HHHHHRKCTGSAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLD 1192
            .|..:.:|:....|.| |:|:|.::                                  |.::|.
 Worm   280 GHGKYEQCSSDEADRE-VASIEMVK----------------------------------QTEVLQ 309

  Fly  1193 EEKDKMSKSQDYDEIWDCDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHY 1257
            .:|......:..:|:           .:.|.|.....|         |||....|.|...|
 Worm   310 RKKTIEDLEESVNEL-----------QSLGNGSWFPHP---------PPPPAEARDQIYES---- 350

  Fly  1258 HSPQPLVHPRKVLPIHHHALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASL 1322
                        ||......||:.        |:....|:...:|.::          .|||:..
 Worm   351 ------------LPASFRNRKSEN--------RKNAVGSVYDNAAISS----------KPSSSET 385

  Fly  1323 HSGLGDSGGIQELCTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKW 1387
            .|.......|........:.||:.:..|:|....|.::::...:.|.:.| ..|||.:||:||.|
 Worm   386 TSFSQQKPIIDRKPFSLENLPMVQRLTELSAAKKNADSKNEVAKRSNTFS-LQLAERDAVDACSW 449

  Fly  1388 LRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQ 1452
            ||.|||.:||..:|:.:.||   ..:||.|.||.| |::|.||:.|||||.||::|     ..|.
 Worm   450 LRKAGFSKYADQFEEGKLPI---VASKDPTLLEAD-LRALNRRIDVLNRCHTMKVD-----SVPM 505

  Fly  1453 QKE-----------ESDDENFALSEHWTF-----QPHIRRWSRI---------GEMGL------- 1485
            ::.           :.||.:...|:.|.:     ..|...|||.         |.:..
 Worm   506 RRRINNEFPRLDPMKIDDNSGYSSDSWRYGSVGGSHHSNTWSRPSGSDHHVYGGSLARMPNSTSS 570

  Fly  1486 ----ELPPPGLLSLNVEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSG 1546
                ::..|...|..|.:|:....:::|.|...:....|..:..|      .|:.:|
 Worm   571 AWHHQMADPTRDSRKVLRTDWYDAQNTPPRGRNNDVLETASSAAC------VNELNS-------- 621

  Fly  1547 RLRRSGSERIKDQAKALLRRVESIKSRRRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAV--- 1608
            :|:||.||||||:|:|::::::...:.:|.::.|                |:.:.:...|.|
 Worm   622 KLQRSQSERIKDRARAIMKKMDLRSTNKRPKETR----------------GRPAPMNIGDPVLVS 670

  Fly  1609 YSTPPS---------PSALSP--MHTFPKAPFFGNDLKVPSHSDNFLSPNRSSPK--RTPTTPRS 1660
            |.||.:         ||.|..  ...:|.:|:     :.||.|.:....||....  .|||:|.|
 Worm   671 YDTPKNSIRSHHIDRPSILPERGRQLYPTSPY-----QAPSRSKSIAQNNRRGGLVFITPTSPNS 730

  Fly  1661 MRTSPLHFFSSPMSQLKEGKSDDSSSYYSD--SQESSTGGKLSLRKPSKAR-------------- 1709
            :.||             .|.||.:||..|.  |...|...:||:..||:.|
 Worm   731 LDTS-------------FGYSDTNSSVVSSHRSNGESRRRELSMPPPSRHRVQMNGPSYPVMDGT 782

  Fly  1710 ------------------RFLQRTGKV-------------DDIGAHSDSECHQGRKLLIKDANSN 1743
                              :.|:|..|.             ||:   .|....:..|....::.||
 Worm   783 LRRREIMPFDSYLYAGNPKMLERYDKTYESPRNLIPDRMYDDL---DDLPLPKSTKTTNSNSTSN 844

  Fly  1744 TTEVKVKK--------------------------LTRGGSLNLGKDPKKRDGFRSS--------- 1773
            :..:..||                          ||.....||..:.:|.|...||
 Worm   845 SNSLDNKKTDNISMFNDGYYTHEIKTALPRHHNILTTVKPENLKVNTEKIDIISSSDEPIGRTAL 909

  Fly  1774 ---------SFRSRSTSRKEAKNDEDT----AGATTNGGSKRQPVVRWHSFQM---EERPNMIFR 1822
                     |..|||.|....:....:    :.||::..| ......|.|...   |::|
 Worm   910 TKRSDSGLGSSLSRSPSGPHTQRIRQSLLPYSNATSSSAS-AYSCCSWGSSTKLLDEQQP----- 968

  Fly  1823 KCFSKKIEPLQEDAGGMPFAAMSAGQLQII-----RKLALVTLTGHMER---------------Y 1867
             .|:..:|           .|.|...|.:|     ||.|.:.|:..:||               .
 Worm   969 -FFTDMVE-----------LARSIDSLNLIEMTRLRKTAFLRLSSILERNIEGKGVGLVDPDQEE 1021

  Fly  1868 CPSHRSGWNWELPKFIKKIKMPDYK--------DKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQ 1924
            .||...   |.:.:.||::|:.|.:        |..||||.|.:|..|:|..||..:....::|:
 Worm  1022 LPSKHV---WSVQRLIKRMKINDGQKREKDVDGDGAVFGVGLDVIFNRTGYFLPRPILEVMKFLR 1083

  Fly  1925 LNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVF------DLQQAYDVADMLKQYFRELP 1983
            ..|.:.||||||:|.||||.:||..||   |.:...|||      |..|.:||||:||||||:||
 Worm  1084 NIAPETVGIFRKNGVKSRIAELRSIIE---SYSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLP 1145

  Fly  1984 ESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSN 2048
            |.|:|.||||.|..|...:|...|:.|:|.|:|||||||||.|..||.||..|:.|||.|.||:.
 Worm  1146 EPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQ 1210

  Fly  2049 NLGVCLAQSIFHSSISTGSASVSASPRRKGKG-SGMPDMKELAEAKASHECLSFMIEHYKQIYTA 2112
            ||.||...|:|....|........:.|.|..| :|:|..||:.||:|...||:.:||:.:.::..
 Worm  1211 NLSVCFTPSLFQLGASRLDKVTPGNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMV 1275

  Fly  2113 AKEKLSKCNFSYMEESKPLPLEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSS 2177
            ........:   .|:..| .|..||    ....|.:|.:.....|::..::.:.|....|..  .
 Worm  1276 PDGLDDSMD---AEDDNP-NLTELG----LKGPRSFLVDRVIDLIRDHSDQWKNWTIEGSFR--G 1330

  Fly  2178 VDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLD-DRTEIYQYA 2241
            ::|:.|:..|.|||:.:|....:...||.|:..::|:|.:||::::..:.::.:. ..|:|:||.
 Worm  1331 IEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLEYVSAPDTDIHQYV 1395

  Fly  2242 LD---GQLTTDFCVLRSWQTDLP--RGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSG 2301
            ::   |..|.|..|.|...:.|.  ||||.|.|.|:...:.: |.|.|...:...|:||||...|
 Worm  1396 VNETIGHPTKDCHVARFHSSGLTEIRGACAIAERSVKCTEDQ-LLGGVSATIFDQRFLIEPVSGG 1459

  Fly  2302 RSRVMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHVAD--GPESKV 2351
            :|||.::||||:||::.:||||::|.|...:|.|:|.:| |:.|  |||:.|
 Worm  1460 QSRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESF-HLGDKGGPETNV 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	30/58 (52%)
		RhoGAP_DLC1	1893..2116	CDD:239840	102/229 (45%)
		SRPBCC	2148..2343	CDD:472699	63/200 (32%)
gei-1	NP_497694.3	SAM_superfamily	444..499	CDD:472832	30/58 (52%)
		RhoGAP_DLC1	1052..1279	CDD:239840	102/229 (45%)
		SRPBCC	1302..1501	CDD:472699	64/202 (32%)