DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-c and DLC1

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001335010.1	Gene:	DLC1 / 10395	HGNCID:	2897	Length:	1528	Species:	Homo sapiens

Alignment Length:	1532	Identity:	452/1532 - (29%)
Similarity:	710/1532 - (46%)	Gaps:	347/1532 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1037 LVDVTKKGSTSTI-WTSEESILRSVGAVDEDNNSTSSSSACEEATGVLSSGKSGISLDSSGLDND 1100
            ||.|:.:.:.:.: .|.::.:|.:.|......:....:.:.|:|..::.|.:  :|.:|.|:..:
Human   107 LVHVSDEDNNADLCLTDDKQVLNTQGQKTSGQHMIQGAGSLEKALPIIQSNQ--VSSNSWGIAGE 169

  Fly  1101 N-----NESGIGTATPPKDMSHYWKSHHLQHHHHHHHRKCTGSAQDNESVS-SLEALRKMKFQKS 1159
            .     .|||                          .||.|      :|:| |||...::...:.
Human   170 TELALVKESG--------------------------ERKVT------DSISKSLELCNEISLSEI 202

  Fly  1160 GSVASSDDPDVLEVLSQCGSGGEANES-------QDDMLDEEKDKMSKSQDYDEIWDCDCTD--- 1214
            ......:..|.|.|..........|.:       :.|...:|.::.:.:...:|..|..||:
Human   203 KDAPKVNAVDTLNVKDIAPEKQLLNSAVIAQQRRKPDPPKDENERSTCNVVQNEFLDTPCTNRGL 267

  Fly  1215 ----GDASSA-----SGGGGVTATPVILRRKYT-----APPPIL----VPRTQRSHSLDHYHSPQ 1261
                .|..|.     |...|::|...:.:..::     :||.:.    :...|...:|.......
Human   268 PLLKTDFGSCLLQPPSCPNGMSAENGLEKSGFSQHQNKSPPKVKAEDGMQCLQLKETLATQEPTD 332

  Fly  1262 PLVHPRKVLPIHHHALKSKERGQLSLVLR--------QEPFQSLLSPSATAANQLHHFVELPSPS 1318
            ..|..||...|.....:::....:.|:::        :....:..|||.|..|...|..:|.|.|
Human   333 NQVRLRKRKEIREDRDRARLDSMVLLIMKLDQLDQDIENALSTSSSPSGTPTNLRRHVPDLESGS 397

  Fly  1319 SASLHSGLGDSGGIQEL------CTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLA 1377
            .:.     .|:..:.:.      .|:|...|..........:......|.:        |::..|
Human   398 ESG-----ADTISVNQTRVNLSSDTESTDLPSSTPVANSGTKPKTTAIQGI--------SEKEKA 449

  Fly  1378 EIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRL 1442
            ||||.|||.||||.|||||||:|||..||||::.|.::|..|:.|.:::|.|||..||:||.|:|
Human   450 EIEAKEACDWLRATGFPQYAQLYEDFLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKL 514

  Fly  1443 DQSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGL------------------ELPP 1489
            :.|  |...:..:..:||..|:|..||||...:||||:.|..:                  :.|.
Human   515 EIS--PHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPS 577

  Fly  1490 PG--LLSLNVEKTESSSKES----------SPDRFEEDGAGITLVTPG-------CSKAGGIPND 1535
            ||  |:.|: |:.|.||..|          :|.  .||.|     ||.       ||.:....||
Human   578 PGGTLMDLS-ERQEVSSVRSLSSTGSLPSHAPP--SEDAA-----TPRTNSVISVCSSSNLAGND 634

  Fly  1536 GS--SLGEGSD--SGRLRRSGSER-IKDQAKALLRRVESIKSR-----RRKRQNRENVVISGP-- 1588
            .|  ||....:  |......|.|: .|.:.::||:|:||:|.:     :.|..::..::||||
Human   635 DSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPIL 699

  Fly  1589 ---------------------------------TVLDLSQFGQRSSLRKPDAVYSTPPSP----- 1615
                                             :|.:.:|....||..:..:..|| |||
Human   700 QEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSSAVST-PSPVTRTR 763

  Fly  1616 --SALSP---MHTFPKAPF----FGNDLKVPSHSDNFLSPNRSS-PKRT----------PTTPRS 1660
              ||.:.   |:.....||    |.|.::     .||  .||.| |:.|          .|.|::
Human   764 SLSACNKRVGMYLEGFDPFNQSTFNNVVE-----QNF--KNRESYPEDTVFYIPEDHKPGTFPKA 821

  Fly  1661 M----------------RTSPLHFFSSP--MSQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSK 1707
            :                ||...|   .|  :|..:|..||........:..||...:||:.....
Human   822 LTNGSFSPSGNNGSVNWRTGSFH---GPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVP 883

  Fly  1708 ARRFLQRTG------------KVDDIGAH--------------------------SDSECHQGRK 1734
            .......:|            ::|||..|                          |.|.|....|
Human   884 GSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPK 948

  Fly  1735 LLIKDA-NSNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNG 1798
            .:..|. |..||...:.  :.|.|||..::|                |....:.|.....:.|..
Human   949 QIHLDVDNDRTTPSDLD--STGNSLNEPEEP----------------SEIPERRDSGVGASLTRS 995

  Fly  1799 GSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGH 1863
            ...|   :||||||...||::               ::..:.....|..|:.:::|.:|:.||..
Human   996 NRHR---LRWHSFQSSHRPSL---------------NSVSLQINCQSVAQMNLLQKYSLLKLTAL 1042

  Fly  1864 MERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNAL 1928
            :|:|.||::.|::|.:|||:|:||:|||||:.||||||.:.:||:||.||.:::.|.|:|:.:.|
Human  1043 LEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCL 1107

  Fly  1929 DQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSE 1993
            ||||:|||||.||||..||   ::.:...:|:: ::.|.|||||||||||||:|||.|:|.|:||
Human  1108 DQVGLFRKSGVKSRIQALR---QMNEGAIDCVN-YEGQSAYDVADMLKQYFRDLPEPLMTNKLSE 1168

  Fly  1994 TFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSI 2058
            ||:.|:|::|.:.||.|::.|::||||||||:|..||.||:.|.|..::||||..||.||||.|:
Human  1169 TFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSL 1233

  Fly  2059 FHSSISTGSASVSASPR--RKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCN 2121
            ||  ::|.... ::|||  ::.:..|.||.|:|.|..|:.:.|:.||...|::: ...|::|:|.
Human  1234 FH--LNTLKRE-NSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLF-QVPEEMSRCR 1294

  Fly  2122 FSYME-ESKPLPLEALGEGMQFH-------NWRGYLYECTSATIKEGREKTRGWFSINSLNDSSV 2178
            .||.| |.|||.|||||     |       :::.:|.:|.....||.:||.:||.|.::  ....
Human  1295 NSYTEQELKPLTLEALG-----HLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYST--SEQA 1352

  Fly  2179 DIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALD 2243
            :::||||.:|.||||||...|:...|:|:|:.::|::..||.:||..:.::.||.:||||||..:
Human  1353 ELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQN 1417

  Fly  2244 GQL---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRV 2305
            ...   ..|:.|||:|:|:||:|||.::.||:||.:| |:.| ||..||.|||||||||.|:|::
Human  1418 SMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRA-PVVG-VRVNVLLSRYLIEPCGPGKSKL 1480

  Fly  2306 MHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKH 2342
            .::.|||::|..||||.|::||:|:..:.:||.:|.:
Human  1481 TYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSN 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	33/58 (57%)
		RhoGAP_DLC1	1893..2116	CDD:239840	107/224 (48%)
		SRPBCC	2148..2343	CDD:301327	85/198 (43%)
DLC1	NP_001335010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..310		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..436		13/68 (19%)
		SAM_DLC1	454..513	CDD:188990	33/58 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..617		15/66 (23%)
		Focal adhesion-targeting (FAT)	710..884		37/184 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..764		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..876		10/49 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..990		15/79 (19%)
		Polybasic cluster (PBR)	1051..1073		12/21 (57%)
		RhoGAP_DLC1	1072..1290	CDD:239840	108/225 (48%)
		START_STARD12-like	1315..1518	CDD:176917	85/207 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3097
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4702
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm40592
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	LDO	PTHR12659
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760