DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-c and stard8

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_004916864.1	Gene:	stard8 / 100494346	XenbaseID:	XB-GENE-992346	Length:	1049	Species:	Xenopus tropicalis

Alignment Length:	1125	Identity:	377/1125 - (33%)
Similarity:	562/1125 - (49%)	Gaps:	206/1125 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1351 MSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKD 1415
            ::|.:....|.....|..|..|.....::||.:||.||||||||||||:|||.|||:|::.|.:|
Frog     7 LNRSYFKDRASKTWQRLRRRLSAPLELDLEAKKACDWLRAAGFPQYAQLYEDSQFPVDISCVKRD 71

  Fly  1416 HTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESD-DENFALSEHWTFQPHIRRWSR 1479
            |:.|:.|.|:||.|||..||.||.|:|:..::    :|.|:|| |:..|:|:.|.||....||||
Frog    72 HSFLDEDSLKSLCRRLMTLNSCAPMKLEVHYR----KQNEDSDEDDQCAISDRWAFQRDQGRWSR 132

  Fly  1480 IGEMGLELP----PPGL------------LSLNVEKTESSSKESSPDRFEEDGAGITLVTP-GCS 1527
            :..:.|..|    ||.:            ||..:|.|...|..||     ..|..|.::.| |.|
Frog   133 LDSVELLSPTYAGPPTIKSTSSRDSILTDLSTELEATSLQSAGSS-----RGGLDIVVIPPQGMS 192

  Fly  1528 KAGGIPNDGSSLGEGSDSGRL--RRSGSERIKD-QAKALLRRVESIKSRRRKRQNRENVVISGPT 1589
            .....|.........||....  ||...|:.|. :.:..|:|:||:: ||.|.:.::.|
Frog   193 SVSSSPAPSKPCRSLSDQSLAPQRRGLKEKTKKRKTRGFLKRMESLR-RREKDKGKKEV------ 250

  Fly  1590 VLDLSQFGQRSSLRKPDAVYSTPPSPSAL--SPMHTFPKAPFFGNDLKVPSHSDNFLSP------ 1646
                                   ||.|||  |...|...|....:|...|....:||.|
Frog   251 -----------------------PSDSALDDSGRETLSYANHCADDGDFPVFEKDFLHPGYRTKC 292

  Fly  1647 --------------------------------NRSSPK-----------RTPTTPRSMRTSPLHF 1668
                                            .|:|.|           :..|.||::....|..
Frog   293 ASSGSIRKPHLDGQCRGVYLEDFEMVRKDGIRQRNSQKSDRLVCIPTDHKPGTFPRALSIESLCP 357

  Fly  1669 FSS-PMSQLKEG---------KSDDS---------SSYYSDSQESS-----------TGGKLSLR 1703
            .|. |:...|.|         .|.||         .||.|....||           :|..|.|
Frog   358 ASRVPLESWKMGSKSLGQSVCSSMDSHGLEGRPRRGSYSSIGSRSSIYDNVPCSLSGSGDHLEL- 421

  Fly  1704 KPSKARRFLQRTGKVDDIGAHSDSECHQGRKL-LIKDANSNTTEVKVKKLTRGGSLNLG----KD 1763
                        |...|:..|.|...:..|.| .:.:..|.|...::.:.|..|....|    ::
Frog   422 ------------GGSSDLFGHLDDVLNHVRGLQRMVELWSRTVCPELDEGTDSGGEQAGHLAYEE 474

  Fly  1764 PKKRD-GFRSSSFRSRSTSRKEAKNDEDTAGATTN-GGSKRQPV--VRWHSFQMEERPNMIFRKC 1824
            ....| |..:|.|.|...|..|.:.:|......:. |.|..:|.  :||||||...||::
Frog   475 RSISDVGTSASDFDSTGNSLNETEENEMRERRDSGVGASLTRPCRKLRWHSFQNSHRPSL----- 534

  Fly  1825 FSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMP 1889
                      .:..:.....||.||.:::||:|:.||..||::....:.||.|.:|||:|:.|:|
Frog   535 ----------SSASLEINRQSAAQLNLLQKLSLLRLTAIMEKHSVPSKQGWAWTVPKFMKRSKVP 589

  Fly  1890 DYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTD 1954
            ||:.:.||.||.::.:||:||.||.:::.|.|:::...|||||||||||.||||..||:..|.:.
Frog   590 DYRGRAVFSVPPIINVQRTGQPLPQSIQQAMRYIRSQCLDQVGIFRKSGVKSRIQALRQMNESSP 654

  Fly  1955 STAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLP 2019
            .....:.    |.||||||:||||||:|||.:.|:|:::||:.|:|::|.|.||.|||.|:||:|
Frog   655 DHVSYVG----QSAYDVADLLKQYFRDLPEPIFTSKLTDTFLQIYQYVPKEQRLRAVQAAILLMP 715

  Fly  2020 DENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPR---RKGKGS 2081
            |||||:|..||.||:.: :::|.||||..||.||||.|:||.:||....|   |||   |:|. |
Frog   716 DENREVLQTLLYFLSDI-SSAQINQMTPGNLAVCLAPSLFHLNISKKETS---SPRVMHRRGT-S 775

  Fly  2082 GMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYM-EESKPLPLEAL-----GEGM 2140
            |.|..|:|:|..|:.:.|..||...|:::....:.:.:...||: .::.||.||.|     ||..
Frog   776 GKPGHKDLSENLAATQGLLHMITECKKLFQIPHDMMLQSRNSYVAADAHPLSLEELAGVSEGEPQ 840

  Fly  2141 QFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPK 2205
            :..:   .|.....:.::|..|:.:||.:::|  ..:.:::.||:|||:|||:|:.|||:|.||.
Frog   841 ELSS---VLDNSIQSLLQESVERFKGWVTMSS--PENTELSCKKLGDGNPLRVWKVSTEVEAPPS 900

  Fly  2206 EVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDLPRGACVI 2267
            .:|..|:::|..||.:|||.:.::.|...|||:.|..|...   ...|.|||.|:||||||.|::
Frog   901 SLLHRVLRERHLWDDDLLQGKVLETLGQNTEIFHYVTDTMAPHPRRQFLVLRKWRTDLPRGGCLL 965

  Fly  2268 VETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYGHICSHY 2332
            |.|||||: .:.|...|:.|:|:|:||:||||.|||::.::.|.|::|::|:||||.:||:|:..
Frog   966 VSTSIDHS-TRQLDEGVQAVILSSQYLMEPCGMGRSKLTYICRTDLRGRSPDWYNKVFGHLCAME 1029

  Fly  2333 LSRIRLAFKHVAD-GPESKV 2351
            ::|||.:|..:.. |||:::
Frog  1030 IARIRNSFPPLNPCGPETQL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	36/58 (62%)
		RhoGAP_DLC1	1893..2116	CDD:239840	106/225 (47%)
		SRPBCC	2148..2343	CDD:301327	82/197 (42%)
stard8	XP_004916864.1	SAM_DLC1,2-like	38..97	CDD:188937	36/58 (62%)
		RhoGAP_DLC1	594..810	CDD:239840	106/224 (47%)
		SRPBCC	836..1040	CDD:387369	84/209 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12659
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100