DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-c and arhgap40

DIOPT Version :9

Sequence 1:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_004918589.2	Gene:	arhgap40 / 100493159	XenbaseID:	XB-GENE-6050151	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	124/527 - (23%)
Similarity:	207/527 - (39%)	Gaps:	109/527 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1635 KVPSHSDNFLSPNRSSPKRTPTTPRSM---------RTSPLHFFSSPMSQLKEGKSDDSSSYYSD 1690
            |:|  ...||..||:....|.:.|..|         |.:.|..|...:..:|:.:..|.....|.
Frog    15 KIP--RPQFLPANRTPLNSTQSCPCKMSRMLPIPATRQASLSDFWLEVEHIKQTRGPDVEECNSS 77

  Fly  1691 SQESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVKVKKLTRG 1755
            ....:..|:..       ..:||..|....||.....|.:     :|....:.|....|::....
Frog    78 DSGITEDGEAE-------AAWLQDAGLSTLIGDQYPLEDN-----IIMSTLTQTQAAAVRRRLDT 130

  Fly  1756 GSLNLGKDPKK--------------RDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQP-- 1804
            .|.::.|..|:              .|||...:.:.|:....:|.....|.....:....|.|
Frog   131 YSYSVRKRWKQPARDVRFVFTGKGTADGFFRKNGKVRTFGPPQAPGGVPTLPRMGSDNQHRVPGG 195

  Fly  1805 --VVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQL---QI----------IRK 1854
              :........|:..:|      .|:.:...:|||..|...::.|:|   |:          :..
Frog   196 ADIFDTDVAYSEQAASM------RKQEQASVQDAGAFPKFQLNKGRLGTTQVADLTPSDMKQVPA 254

  Fly  1855 LALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGV--PLLMILQRS---GQTLPL 1914
            |||:.||...:..        :.||.:  .|::.....:.::|||  |.|:|..:.   ...:||
Frog   255 LALIELTALCDVL--------DLELKR--NKVQKRKSAESQLFGVALPSLLIQDQKLVPDTKVPL 309

  Fly  1915 AVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIE--VTDSTAECMDVFDLQQAYDVADMLKQ 1977
            .::|.|..::.|.::..||.|.||.::||..|::::|  ..|......||    ..:|.:.:||.
Frog   310 ILQAIFTCIEKNGMEIQGILRISGSQARIKNLQQRLEKDFYDGLFSWDDV----HPHDASGLLKL 370

  Fly  1978 YFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQ 2042
            :.||||..||||:....|.|:...:..:.||.|:...:|:||:.||..|..|||||..|||..:.
Frog   371 FLRELPAPLLTTQYLPAFTAVQNIVDLKQRLQALNLLILILPEPNRSTLKALLEFLQKVAAMEKT 435

  Fly  2043 NQMTSNNLGVCLAQSIF--H--SSISTGSASVSASPRRKGKGSGMPDMKELAEAKASHECLSFM- 2102
            |.|:..|:...||.::|  |  .::..|.                   |:|||..|:    |.|
Frog   436 NLMSLWNVSTILAPNLFLYHCGKNLERGE-------------------KQLAEGTAA----SVMA 477

  Fly  2103 IEHYKQI 2109
            :.||:.:
Frog   478 MVHYQDL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	70/229 (31%)
		SRPBCC	2148..2343	CDD:301327
arhgap40	XP_004918589.2	RhoGAP	286..497	CDD:413382	70/226 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910