Protein Alignment cv-c and LOC100490096

DIOPT Version :10

• Sequence 1: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_031754649.1
• Gene: LOC100490096 / 100490096
• XenbaseID: XB-GENE-29080035
• Length: 1086
• Species: Xenopus tropicalis
• Alignment Length: 1120
• Identity: 350/1120 - (31%)
• Similarity: 540/1120 - (48%)
• Gaps: 219/1120 - (19%)

  Fly  1369 RSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCV 1433
            :|..:|.|:||||.|||.||||||||||||:|||.||||::..|..||..|:.|.::||||||..
 Frog    30 KSARERRLSEIEAKEACDWLRAAGFPQYAQLYEDLQFPINIELVKNDHEFLDRDAMESLYRRLNT 94

  Fly  1434 LNRCATMRLDQSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPP--------- 1489
            ||:||.|:::.:.:.:...:.||  ||..|:|..|::|...:||||:..:...||.
 Frog    95 LNKCAAMKIEINRRRKRSDESEE--DEPCAISNKWSYQRQSQRWSRLENLDCPLPDEASCLSLPI 157

  Fly  1490 -PGL--------LSLNVEKTESSS--------KESSPDRFEEDGAGITLVTPGCSKAGGIPNDGS 1537
             |.|        .||.::|.::||        .:|||..:||  ...:..:..||....:..|.:
 Frog   158 IPVLNIPKEDAAFSLLIDKNDTSSLHSSSSGESDSSPKPYEE--LETSRSSSRCSSIKFVSLDST 220

  Fly  1538 SLGEGSDSGRLRRSGSERIKD-----QAKALLRRVESIKSR----RRKRQNRENVVISGPTVLD- 1592
            .....|.|..|.....|||.|     :.|:|:||:|.::.|    :|....::...||||.:||
 Frog   221 FSPSPSPSEMLNVISEERIIDKPPSKKGKSLIRRMEKLRIRSSTVKRNTHLKDKPTISGPVLLDG 285

  Fly  1593 -------------------------LSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKAPFFGN 1632
                                     .|...|..|...|....||..:||.:
 Frog   286 LDEDKLRNLNCVNISDLADTHSKAGFSCSSQTCSSSSPSETSSTVSTPSPV-------------- 336

  Fly  1633 DLKVPSH-------SDNFLSPNRSS------------------------PK--RTPTTPRSMRTS 1664
             ::|.||       :::| :||:.|                        |:  :..|.|:::..|
 Frog   337 -IRVRSHGKRGGIYAEDF-NPNKLSLWNDISERNFRNERHLREHQIFQIPQGHKPGTFPKALTNS 399

  Fly  1665 PL-------------HFFSSPMSQLKEGKSDDSSSYYSDSQESSTGGKLSL--RKPSKARRFLQR 1714
            .|             .|.....::::...|.||.  ...|..|....:||:  ..|:....|
 Frog   400 ILSPIDNTSVNWRTGSFHGCNRNRMRSSSSKDSE--VPSSPLSLVDNRLSIYDNVPNIPFHF--- 459

  Fly  1715 TGKV-----DDIGAHSDS--ECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKD-----PKKR 1767
             ||:     ||:.:..|:  |...|.:.|:.:.:        :|.:..|..:...|     |...
 Frog   460 -GKLESPGDDDVFSELDNVMEHVNGLRKLVSEWS--------EKFSDDGDSDFANDSISPCPSSP 515

  Fly  1768 DGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPL 1832
            :...........:..|....|.:...:.|...|...|.:.....      :..|..|..:..||:
 Frog   516 NTIHLEVNEHLHSKSKTDIGDVERCKSCTYSDSTTLPYITVSEI------DSTFTDCSRQSPEPV 574

  Fly  1833 QEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVF 1897
            ...   |...:.||..|..|::|||:.||..|::|.||.:.||||.:||||:||:.||||||.||
 Frog   575 NLT---MQVDSQSAAYLNKIQRLALLKLTALMDKYSPSSKQGWNWNVPKFIRKIRAPDYKDKNVF 636

  Fly  1898 GVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDV 1962
            |||.|:.:||:|..:|.::..|..:|:::.|||||:|||||.||||..|||..|.......
 Frog   637 GVPFLLNVQRTGHPIPKSILQAMEYLRIHFLDQVGLFRKSGVKSRIQTLREMNEQDSKYVN---- 697

  Fly  1963 FDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILY 2027
            ::.|.|:|||||:|||||:|||.:.|:|:.|:|:.|:|:||.:.:..|||.|:|||||||||.|.
 Frog   698 YEGQSAFDVADMVKQYFRDLPEPIFTSKLCESFLHIYQYLPKDQQPHAVQAAILLLPDENREALK 762

  Fly  2028 VLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFH-SSISTGSASVSASPRRKGKGSGMPDMKELAE 2091
            :||.||..|.|...:||||..|:.||||.|:|| :::...|:|.|...:|| ...|.||.|:|:|
 Frog   763 ILLYFLRDVVACVTENQMTPTNIAVCLAPSLFHLNTLRRESSSSSRLSQRK-YSLGKPDQKDLSE 826

  Fly  2092 AKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYMEESKPLPLE------------------ALGE 2138
            ..|:.:.|:.||....:::..:......|  ..:.:::|:..|                  :|..
 Frog   827 NLAATQGLAHMIAECNRLFQLSDYWCDMC--PSLCDAQPIHAETSVNTSTNSLAAHCSTLISLEN 889

  Fly  2139 GMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKV-GDGHPLRLWRCSTEIEG 2202
            .||             :.:::.::|.|.|.:.:..  ..|::||||| .|..|:|:|:.|||||.
 Frog   890 SMQ-------------SLLRDAKDKYRSWVACSGF--EHVELAYKKVESDDFPIRMWKASTEIEA 939

  Fly  2203 PPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQ---LTTDFCVLRSWQTDLPRGA 2264
            .|..||:.::|::.:||.||.|.:.::.||:.|:||.|..:..   ...::.|||:|:||...|.
 Frog   940 APHAVLQHILKEQHTWDPNLQQSKIIETLDEDTDIYHYITESMPPLPCREYVVLRTWRTDPQNGT 1004

  Fly  2265 CVIVETSID----HAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNY 2325
            |::..|||:    |      .|.:.|.|:..::|||..|:.:.:|.|..|.|.:|::.|||||.|
 Frog  1005 CILAATSIECEDVH------IGGILGHVILCQHLIENIGTQKCKVTHSCRTDTRGRSTEWYNKVY 1063

  Fly  2326 GHICSHYLSRIRLAF 2340
            ||:|:..:.||:.:|
 Frog  1064 GHMCAAEILRIKDSF 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	37/58 (64%)
		RhoGAP_DLC1	1893..2116	CDD:239840	102/223 (46%)
		SRPBCC	2148..2343	CDD:472699	69/201 (34%)
LOC100490096	XP_031754649.1	SAM_DLC1	43..102	CDD:188990	37/58 (64%)
		RhoGAP_DLC1	632..851	CDD:239840	102/223 (46%)
		START_RhoGAP	886..1078	CDD:176878	71/212 (33%)