Protein Alignment NK7.1 and NKX6-2

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 60/178 - (33%)
• Similarity: 80/178 - (44%)
• Gaps: 32/178 - (17%)

  Fly   321 PAAK-----KKKLSSTVALPPDISPTGSSDSLMRDKLMANNSSSPGSNVNAQMQSNANSTLETTE 380
            |||.     .|.|:.....||...|.....:..||..:|  ..:|...|.
Human    95 PAAAVARGYPKPLAELPGRPPIFWPGVVQGAPWRDPRLA--GPAPAGGVL--------------- 142

  Fly   381 DDSDSGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRR 445
             |.|.      :||.:|.||:|:|||.|||.||..|||:..||..:|..|.:||:|||:||||||
Human   143 -DKDG------KKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRR 200

  Fly   446 TKWKKQDNVTNNEAAEHKSSNA---KPGATGTATTTPSGEPTDKRSSN 490
            |||:|:..|....|.:.:.|:|   |.|.:..........|.|..|.:
Human   201 TKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDD 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	34/55 (62%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		8/46 (17%)
		Homeodomain	147..205	CDD:459649	35/57 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		8/39 (21%)