Protein Alignment NK7.1 and NANOG

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_079141.2
• Gene: NANOG / 79923
• HGNCID: 20857
• Length: 305
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 66/243 - (27%)
• Similarity: 106/243 - (43%)
• Gaps: 47/243 - (19%)

  Fly   300 PATKQSQILGKSATKKESSGKPAAKKKKLS------STVALP--PDISPTGSS-DSLMRDKLMAN 355
            ||..||....:::..||||..|.....:.:      |:..:|  ..:||..|| |.|::|.  .:
Human     5 PACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDS--PD 67

  Fly   356 NSSSPGSNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSA 420
            :|:||    ..:..::|..::...||....      :|:|.||.|:..|:..|...|:.:||||.
Human    68 SSTSP----KGKQPTSAEKSVAKKEDKVPV------KKQKTRTVFSSTQLCVLNDRFQRQKYLSL 122

  Fly   421 SERTEMAKLLMVTETQVKIWFQNRRTK---WKKQDNVTNNEAAEHKSSNAKPGATGTATTTPSGE 482
            .:..|::.:|.::..|||.||||:|.|   |:|.:...|:.....|:|         |.|.|| .
Human   123 QQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKAS---------APTYPS-L 177

  Fly   483 PTDKRSSNATSPTVGNAATIAEIKKSPKSPNRGSNNNNNNTLNNNVNN 530
            .:........:|| ||.            |...:...||:|.:|...|
Human   178 YSSYHQGCLVNPT-GNL------------PMWSNQTWNNSTWSNQTQN 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	23/58 (40%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		24/102 (24%)
		COG5576	74..191	CDD:227863	37/133 (28%)
		Homeodomain	97..152	CDD:459649	22/54 (41%)
		Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768	122..151		11/28 (39%)
		8 X repeats starting with a Trp in each unit	196..240		5/17 (29%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240		5/17 (29%)
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305