| Sequence 1: | NP_650357.2 | Gene: | NK7.1 / 41747 | FlyBaseID: | FBgn0024321 | Length: | 721 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_082292.1 | Gene: | Nanog / 71950 | MGIID: | 1919200 | Length: | 305 | Species: | Mus musculus |
| Alignment Length: | 165 | Identity: | 32/165 - (19%) |
|---|---|---|---|
| Similarity: | 59/165 - (35%) | Gaps: | 52/165 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 494 IRKEMFYP-GEVLND---------IQIIDQVFAQIVEDCKKSYPYRIREQDRKQVETVLRQYEIP 548
Fly 549 PSDLNNQSNIHPDVKVAVIELARLWPLYFNQVYEVVEKRPDESVSTIFAISEHGIRLIVHTPHDL 613
Fly 614 ENPLKIQDFFP--FETIADVSLEANDILSVHVRHE 646 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NK7.1 | NP_650357.2 | Homeodomain | 394..450 | CDD:459649 | |
| Nanog | NP_082292.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..30 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 46..95 | 11/57 (19%) | |||
| Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 | 96..155 | 17/89 (19%) | |||
| Homeodomain | 98..153 | CDD:459649 | 16/85 (19%) | ||
| Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 | 123..152 | 10/49 (20%) | |||
| PTZ00395 | <190..>250 | CDD:185594 | |||
| 10 X repeats starting with a Trp in each unit | 198..247 | ||||
| Sufficient for transactivation activity | 198..247 | ||||
| Sufficient for strong transactivation activity | 248..305 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||