Protein Alignment NK7.1 and NKX2-1

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 81/351 - (23%)
• Similarity: 131/351 - (37%)
• Gaps: 108/351 - (30%)

  Fly   173 GPPTNWHA--------------HVYDRLPPHPTPHSIADILGMSFVKKERPEVAFDAQGPAKSPN 223
            |....|.|              .:....|.|.||.|::|||  |.:::...:|..:. |...:|
Human     7 GKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDIL--SPLEESYKKVGMEG-GGLGAP- 67

  Fly   224 SILKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVATPLDQPLNLCVV 288
              |..|::.|....::     |.::.:....||.:|       |..:|||.|..
Human    68 --LAAYRQGQAAPPTA-----AMQQHAVGHHGAVTA-------AYHMTAAGVPQ----------- 107

  Fly   289 KKSRDSNNSPMPATKQSQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSDSLMRDKLM 353
                               |..||.....:|       .|.:...|||            ....|
Human   108 -------------------LSHSAVGGYCNG-------NLGNMSELPP------------YQDTM 134

  Fly   354 ANNSSSPG--------------------SNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKART 398
            .|::|.||                    |.:|........|..:.:::.:...|..   ::|.|.
Human   135 RNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAP---RRKRRV 196

  Fly   399 TFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHK 463
            .|:..|::|||:.|:.:|||||.||..:|.::.:|.|||||||||.|.|.|:|   ..::||:.:
Human   197 LFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ---AKDKAAQQQ 258

  Fly   464 -SSNAKPGATGTATTTPSGEPTDKRS 488
             ..::..|..|..|..|..:...::|
Human   259 LQQDSGGGGGGGGTGCPQQQQAQQQS 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	28/55 (51%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	28/55 (51%)