Protein Alignment NK7.1 and NKX1-1

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 108/399 - (27%)
• Similarity: 144/399 - (36%)
• Gaps: 67/399 - (16%)

  Fly   137 PRPSSVHPQHQQPQQQTVQLQQQRRSVSTP--AITTTPGPPTNWHAHVYDRLPPHPTPHSIADIL 199
            |.|.:.....|:......:|....|:.:.|  |..|.|..|....| .....|..||..|:.|||
Human    25 PAPPAPAAAAQEAMDGRAELPAFPRAGAPPLAASDTVPAAPEGAGA-ARPAAPLRPTSFSVLDIL 88

  Fly   200 GMSFVKKERPE------VAFDAQGPAKSPNSILKPYQEQQPIRSSSISMSDASEEESAAVAGATS 258
            ..:.....|..      ||..|..|..|......|....:|.|:..:      |..:.|.||...
Human    89 DPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAASGRPPRAEEL------ERRALAGAGGVG 147

  Fly   259 AATA---------AAAVAATITA----------ATVATPLDQPLNLCVVKKSRDSNNSPMPATKQ 304
            ||.|         .|..|.|...          :..|...|:      |....|.:....|.|:.
Human   148 AAGAEPPNAGDPFKAGEAETNDTNGYSSGGGGHSPSADSGDE------VPDDEDDDEDEAPETEA 206

  Fly   305 SQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSDSLMRDKLMANNSSSPGSNVNAQMQ 369
            ::  |....:....|..|   :......|...|.||..:.|.........|:..:.|....|...
Human   207 AR--GAEEARGGGGGLGA---RGSGCQGAAETDASPGATVDEAAAPGPRENSPVAQGPPGGAAAP 266

  Fly   370 SNANST-----------LETTEDDSDSGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSASER 423
            ..|.:|           .:.|..||.||     :.::|||.||..|:..||..|:..:|||..||
Human   267 GGAGTTPQGTATAAKPKRKRTGSDSKSG-----KPRRARTAFTYEQLVALENKFKATRYLSVCER 326

  Fly   424 TEMAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHKSSNAKPGATGTATTTPSGEPTDKRS 488
            ..:|..|.:|||||||||||||||||||:...:..|.........||| |..|..|.|     .|
Human   327 LNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPGPGA-GPGTGLPGG-----LS 385

  Fly   489 SNATSPTVG 497
            ..:.||.:|
Human   386 PLSPSPPMG 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	32/55 (58%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		38/205 (19%)
		Homeodomain	297..353	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		17/51 (33%)