Protein Alignment NK7.1 and NKX6-1

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 115/434 - (26%)
• Similarity: 164/434 - (37%)
• Gaps: 105/434 - (24%)

  Fly   105 MLRV--RDNNNMASTISDSPPTTFLQKQLEAVVAPRPSSVHPQHQQPQQQTVQLQQQRRSVSTPA 167
            ||.|  .:....::.:..|||...|....|......|::..|....|..          |.|:.:
Human     1 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPS----------SSSSSS 55

  Fly   168 ITTTPGPPTNWHAHVYDRLPP----------------HPTPHSIADILGMSFVKKERPE--VAFD 214
            .:::|.||...| :.....||                ..|||.|.|||       .||.  ||..
Human    56 SSSSPSPPLGTH-NPGGLKPPATGGLSSLGSPPQQLSAATPHGINDIL-------SRPSMPVASG 112

  Fly   215 AQGPAKSPNSILKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVATPL 279
            |..|:.||:.            |||.|.|.||...::|.|.|.:||.|||:..|.:.|..
Human   113 AALPSASPSG------------SSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGL----- 160

  Fly   280 DQPLNLCVVKKSRDSNNSPMPATKQSQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTGSS 344
                       .|.|:.|| |..........||....:.|:   ..|.|:......|...|
Human   161 -----------PRFSSLSP-PPPPPGLYFSPSAAAVAAVGR---YPKPLAELPGRTPIFWP---- 206

  Fly   345 DSLMRDKLMANNSSSPGSNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKARTTFTGRQIFELE 409
             .:|:        |.|..:.......:..|.|.    |.|.      ::|..|.||:|:|||.||
Human   207 -GVMQ--------SPPWRDARLACTPHQGSILL----DKDG------KRKHTRPTFSGQQIFALE 252

  Fly   410 KMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQ---DNVTNNEAAEHKSSNAKPGA 471
            |.||..|||:..||..:|..|.:||:|||:|||||||||:|:   :..|..:..:.::...|..:
Human   253 KTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGAS 317

  Fly   472 TGTATTTPSGEPTDKRSSNATSPTVGNAATIAEIKKSPKSPNRG 515
            ..........:|.|..|.:         ..|.::.|..||.:.|
Human   318 ENEEEDDDYNKPLDPNSDD---------EKITQLLKKHKSSSGG 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	34/55 (62%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		32/126 (25%)
		Repressor domain. /evidence=ECO:0000250	102..268		63/227 (28%)
		Homeodomain	235..293	CDD:459649	34/57 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		10/68 (15%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		9/56 (16%)