Protein Alignment NK7.1 and NKX2-2

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 62/196 - (31%)
• Similarity: 89/196 - (45%)
• Gaps: 30/196 - (15%)

  Fly   269 TITAATVATPLDQP----LNLCVVKKSRDSNNSPMPATKQSQILGKSATKKESSGKPAAKKKKLS 329
            |.|..:|...||.|    ....|.:...:.|..|.|| |::..||:.|               |.
Human     6 TKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPA-KRAGPLGQGA---------------LD 54

  Fly   330 STVALPPDISPTGSSDSLMRDKLMANNS---SSPGSNVNAQMQSNANSTLETTEDDS-------D 384
            :..:||.......|||:.....|.:...   |..|....|..|.:::.:.|.:.|:|       .
Human    55 AVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETP 119

  Fly   385 SGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWK 449
            .|..||.:|:|.|..|:..|.:|||:.|..::||||.||..:|.|:.:|.|||||||||.|.|.|
Human   120 GGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMK 184

  Fly   450 K 450
            :
Human   185 R 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	28/55 (51%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		16/65 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		9/40 (23%)
		Homeodomain	129..185	CDD:459649	28/55 (51%)