Protein Alignment NK7.1 and NOTO

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001127934.1
• Gene: NOTO / 344022
• HGNCID: 31839
• Length: 251
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 91/375 - (24%)
• Similarity: 123/375 - (32%)
• Gaps: 154/375 - (41%)

  Fly   121 SPPTTFLQKQLEAVVAPRPSSVHPQHQQPQQQTVQLQQQRRSVSTPAITTTPGPPTNWHAHVYDR 185
            |||.           ||..|.|.|.               ||..:||..:..||.|       .|
Human     9 SPPP-----------APSGSRVRPP---------------RSGRSPAPRSPTGPNT-------PR 40

  Fly   186 LPPH-PTPHSIADILGMSFVKKERPEVAFDAQGPAKSPNSILKPYQEQQPIRSSSISMSDASEEE 249
            .|.. .:|.|:..||.       ||    |...||.|           ||..|:.:.
Human    41 APGRFESPFSVEAILA-------RP----DPCAPAAS-----------QPSGSACVH-------- 75

  Fly   250 SAAVAGATSAATAAAAVAATITAATVATPLDQPLNLCVVKKSRDSNNSPMPATKQSQI---LGKS 311
                    .|...||::.||............|..|.|       ...|:|..:.:.:   ||..
Human    76 --------PAFWTAASLCATGGLPWACPTSWLPAYLSV-------GFYPVPGPRVAPVCGLLGFG 125

  Fly   312 ATKKE---SSGKPAAKKKKLSSTVALPPDISPTGSSDSLMRDKLMANNSSSPGSNVNAQMQSNAN 373
            .|..|   .||..|.            ||.:||
Human   126 VTGLELAHCSGLWAF------------PDWAPT-------------------------------- 146

  Fly   374 STLETTEDDSDSGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVK 438
            ..|:.||          |::|:.||.|...|:.||||:|..:..|...:|.::|..|.:||.||:
Human   147 EDLQDTE----------RQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVR 201

  Fly   439 IWFQNRRTKWKKQDN----VTNNEA-----------AEHKSSNAKPGATG 473
            :||||||.|::||..    ||:.||           |..:|.:|:.|..|
Human   202 VWFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIASIQSDDAESGVDG 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	25/55 (45%)
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		17/70 (24%)
		PHA03247	<16..120	CDD:223021	35/170 (21%)
		Homeodomain	157..213	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..251		6/26 (23%)