Protein Alignment NK7.1 and HOXC13

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_059106.2
• Gene: HOXC13 / 3229
• HGNCID: 5125
• Length: 330
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 65/345 - (18%)
• Similarity: 107/345 - (31%)
• Gaps: 128/345 - (37%)

  Fly   222 PNSILKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVATPLDQPLNLC 286
            |.|::..|::            .|:|.......|.....|..|....:..:...|..:|...:.|
Human    12 PESLMYVYED------------SAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSC 64

  Fly   287 VVKKSRDSNNSPM----PATKQSQILG--KSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSD 345
            .....||....|:    ||.     ||  :.|...:.....||::       ..||...||.||.
Human    65 PASHCRDLLPHPVLGRPPAP-----LGAPQGAVYTDIPAPEAARQ-------CAPPPAPPTSSSA 117

  Fly   346 SL-----------------------------MRDKLMANNSSSPGSNVNAQMQSNA--------- 372
            :|                             ..||....:.:.||.:::::.:..|
Human   118 TLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSY 182

  Fly   373 -----------------------------------------NSTLETTEDDSDSGS--------- 387
                                                     :|.:..:::.|.|..
Human   183 QAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDV 247

  Fly   388 -------TDARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRR 445
                   :..||.:|.|..:|..|:.||||.:...|:::..:|..::....::|.||.|||||||
Human   248 VPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRR 312

  Fly   446 TKWKKQDNVTNNEAAEHKSS 465
            .|.||   |.:...|.|..|
Human   313 VKEKK---VVSKSKAPHLHS 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	21/55 (38%)
HOXC13	NP_059106.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..50		3/19 (16%)
		HoxA13_N	54..168	CDD:463521	24/125 (19%)
		Homeodomain	261..312	CDD:459649	18/50 (36%)