Protein Alignment NK7.1 and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 449
• Identity: 127/449 - (28%)
• Similarity: 173/449 - (38%)
• Gaps: 106/449 - (23%)

  Fly   105 MLRV--RDNNNMASTISDSPPTTFLQKQLEAVVAPRPSSVHPQHQQPQQQTVQLQQQRRSVSTPA 167
            ||.|  .:....::.:..|||...|....|......|::..|....|..          |.|:.:
Mouse     1 MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPS----------SSSSSS 55

  Fly   168 ITTTPGPPTNWH---------AHVYDRL--PPH----PTPHSIADILGMSFVKKERPE--VAFDA 215
            .:::|.||...|         |.....|  ||.    .|||.|.|||       .||.  ||..|
Mouse    56 SSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDIL-------SRPSMPVASGA 113

  Fly   216 QGPAKSPNSILKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVATPLD 280
            ..|:.||:.            |||.|.|.||         ||||:.||||.||...||.     .
Mouse   114 ALPSASPSG------------SSSSSSSSAS---------ATSASAAAAAAAAAAAAAA-----S 152

  Fly   281 QPLNLCVVKKSRDSNNSPMPATKQSQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSD 345
            .|..| :....|.|:.|| |..........||....:.|:   ..|.|:......|...|
Mouse   153 SPAGL-LAGLPRFSSLSP-PPPPPGLYFSPSAAAVAAVGR---YPKPLAELPGRTPIFWP----- 207

  Fly   346 SLMRDKLMANNSSSPGSNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKARTTFTGRQIFELEK 410
            .:|:        |.|..:.......:..|.|.    |.|.      ::|..|.||:|:|||.|||
Mouse   208 GVMQ--------SPPWRDARLACTPHQGSILL----DKDG------KRKHTRPTFSGQQIFALEK 254

  Fly   411 MFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHKSSNAKPGA-TGT 474
            .||..|||:..||..:|..|.:||:|||:|||||||||:|:      .|||..::..|..: |..
Mouse   255 TFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKK------HAAEMATAKKKQDSETER 313

  Fly   475 ATTTPSGEPTDKRSSNATSPTVGNAATIAEIKKSPKSPNRGSNNNNNNTLNNNVNNSEG 533
            ...|...|..|...:....|. .:...|.::.|..||        :..:|..:.:.:||
Mouse   314 LKGTSENEEDDDDYNKPLDPN-SDDEKITQLLKKHKS--------SGGSLLLHASEAEG 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	34/55 (62%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		37/138 (27%)
		Repressor domain. /evidence=ECO:0000250	102..269		67/227 (30%)
		Homeodomain	236..294	CDD:459649	34/57 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		16/84 (19%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		12/66 (18%)