DRSC/TRiP Functional Genomics Resources

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Protein Alignment NK7.1 and Cdx2

DIOPT Version :10

Sequence 1:NP_650357.2 Gene:NK7.1 / 41747 FlyBaseID:FBgn0024321 Length:721 Species:Drosophila melanogaster
Sequence 2:NP_031699.2 Gene:Cdx2 / 12591 MGIID:88361 Length:311 Species:Mus musculus


Alignment Length:347 Identity:81/347 - (23%)
Similarity:118/347 - (34%) Gaps:100/347 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 AQGPAKSPNSILKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVA--T 277
            ||.|..|     .|.....|:|......:......:.|||...:..:.|||:..:..|...|  .
Mouse    58 AQSPGPS-----WPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHH 117

  Fly   278 PLDQPLNLCVVKKSRDSNNSPMPATKQSQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTG 342
            |...|.:               ||...|...|...|.......|||        .|....:||:|
Mouse   118 PHHHPHH---------------PAASPSCASGLLQTLNLGPPGPAA--------TAAAEQLSPSG 159

  Fly   343 SSDSL---MRDKLMANNSSSPGSNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKARTTFTGRQ 404
            ...:|   ||         .|.       |.:..|.::|            |.|.|.|..:|..|
Mouse   160 QRRNLCEWMR---------KPA-------QQSLGSQVKT------------RTKDKYRVVYTDHQ 196

  Fly   405 IFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHKSSNAKP 469
            ..||||.|...:|::...::|:|..|.::|.||||||||||.|.:|   :...:..:.:....:|
Mouse   197 RLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK---IKKKQQQQQQQQQQQP 258

  Fly   470 GATGTATTTPSGEPTDKRSSNATSPTVGNAATIAEIKKSPKSPNRGSNNNNNNTLNNNVNNSEGK 534
                   ..|..:|        :.|..|...::.|    |.||               |.:.:|.
Mouse   259 -------PQPPPQP--------SQPQPGALRSVPE----PLSP---------------VTSLQGS 289

  Fly   535 VPAKQSTTKIKKQLNALLEKTV 556
            ||.  |...:......:|..||
Mouse   290 VPG--SVPGVLGPAGGVLNSTV 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NK7.1NP_650357.2 Homeodomain 394..450 CDD:459649 25/55 (45%)
Cdx2NP_031699.2 Caudal_act 13..178 CDD:461413 34/163 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..151 11/62 (18%)
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626 185..215 11/29 (38%)
Homeodomain 187..242 CDD:459649 25/54 (46%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626 227..241 11/13 (85%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..311 19/110 (17%)
4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724 281..293 6/28 (21%)

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