Protein Alignment NK7.1 and CDX1

DIOPT Version :10

• Sequence 1: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 65/223 - (29%)
• Similarity: 89/223 - (39%)
• Gaps: 37/223 - (16%)

  Fly   297 SPMPATKQSQILGKSATKKESSGKPAAKKKKLSSTVALPPDISPT----GSSDSLMRDKLMA-NN 356
            :|.||.|...    :|........|||....|:  ...|||.||.    |....|:...|.. ..
Human    63 APFPAPKDDW----AAAYGPGPAAPAASPASLA--FGPPPDFSPVPAPPGPGPGLLAQPLGGPGT 121

  Fly   357 SSSPGSNVNAQMQSNANSTLETTEDDSDSGSTDARRKKKARTTFTGRQIFELEKMFENKKYLSAS 421
            .||||    ||..:.......:.......||...|.|.|.|..:|..|..||||.|...:|::..
Human   122 PSSPG----AQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIR 182

  Fly   422 ERTEMAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHKSSNAKPGATGTATTTPSGEPTDK 486
            .::|:|..|.:||.||||||||||.|.:|.     |:..:.:....:|......|.||:|
Human   183 RKSELAANLGLTERQVKIWFQNRRAKERKV-----NKKKQQQQQPPQPPMAHDITATPAG----- 237

  Fly   487 RSSNATSPTVG-----NAATIAEIKKSP 509
                   |::|     |.:.:|.....|
Human   238 -------PSLGGLCPSNTSLLATSSPMP 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	26/55 (47%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		25/99 (25%)
		Caudal_act	13..142	CDD:461413	23/88 (26%)
		Homeodomain	156..211	CDD:459649	26/54 (48%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		8/20 (40%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		9/10 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		13/69 (19%)