DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-B and Xrcc3

DIOPT Version :9

Sequence 1:	NP_476740.1	Gene:	spn-B / 41746	FlyBaseID:	FBgn0003480	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_083151.1	Gene:	Xrcc3 / 74335	MGIID:	1921585	Length:	349	Species:	Mus musculus

Alignment Length:	332	Identity:	109/332 - (32%)
Similarity:	163/332 - (49%)	Gaps:	50/332 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RQQSLHTIVRKCTPD----------DVRVLKDAAAKWL-AEMPQSADSLF--KPLVNVRWSRVSF 90
            |.:|:..|:....||          ||:.|..||:..| .....||..||  |.....:..|:|.
Mouse    20 RLKSVKEILCYSGPDLQRLTGLPSHDVQCLLRAASLHLRGSRVLSALHLFQQKESFPEQHQRLSL 84

  Fly    91 GCSALDRCTGGGVVTRGITELCGAAGVGKTQLLLQLSLCVQLPRELGGLGKGVAYICTESSFPAR 155
            ||..||:..|||:...|||.|.|.:..|||||.|||.|.||.||:.|||..|..|||||.:||::
Mouse    85 GCPVLDQFLGGGLPLEGITGLAGCSSAGKTQLALQLCLAVQFPRQYGGLEAGAVYICTEDAFPSK 149

  Fly   156 RLLQMSKACEKR----HPE---MELNFLGNIFVENHIEAEPLLACVINRIPRLMQQHGIGLIIID 213
            ||.|:. |.::|    .||   .::.|..:||:|:..:.:.||.||..::|.|:.:....|:::|
Mouse   150 RLWQLI-AQQRRLRTDAPEELIEKIRFSNHIFIEHAADVDTLLECVSKKVPILLSRGMARLVVVD 213

  Fly   214 SVAAIFRLYNDYLE----RARHMRRLADALLSYADKYNCAVVCVNQVATR-DGQDEI-------- 265
            |:||.||. ..:|:    ||:.:..|...|...:..:...|:|:|||... :.|..:
Mouse   214 SIAAPFRC-EFHLQASAIRAKLLLSLGATLRRLSSTFRSPVLCINQVTDMVEDQQSVSRSLGASE 277

  Fly   266 ----PCLGLQWAHLGRTRLRVSRVPKQHRMGDQLIT------VRKLEILYSPETPNDFAEFLITA 320
                |.||:.||:....||.|.|..:     |.:.|      ||.|.:|::|..|.....:.::.
Mouse   278 ERLSPALGITWANQLLMRLMVDRTHE-----DDVTTGLPRSPVRTLRVLFAPHLPLSSCCYTVSG 337

  Fly   321 EGVVNVP 327
            ||:..:|
Mouse   338 EGIRGMP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-B	NP_476740.1	Rad51	87..323	CDD:285604	91/265 (34%)
spn-B	NP_476740.1	Rad51_DMC1_radA	88..324	CDD:238543	91/265 (34%)
Xrcc3	NP_083151.1	Rad51_DMC1_radA	82..341	CDD:238543	91/265 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849103
Domainoid	1	1.000	138	1.000	Domainoid score	I4831
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36178
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4489
Isobase	1	0.950	-	0	Normalized mean entropy	S3725
OMA	1	1.010	-	-		QHG58343
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005621
OrthoInspector	1	1.000	-	-		oto94157
orthoMCL	1	0.900	-	-		OOG6_104619
Panther	1	1.100	-	-	LDO	PTHR46487
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1065
SonicParanoid	1	1.000	-	-		X5264
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740