Protein Alignment Set8 and setd2

DIOPT Version :10

• Sequence 1: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: XP_009290459.2
• Gene: setd2 / 794199
• ZFINID: ZDB-GENE-030131-2140
• Length: 2737
• Species: Danio rerio
• Alignment Length: 836
• Identity: 166/836 - (19%)
• Similarity: 274/836 - (32%)
• Gaps: 281/836 - (33%)

  Fly    68 PEATMMAHNKDNKAG---RTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQLNLG----N 125
            ||.:::.:.|.:::.   ..|..|:     |.|::      ...|||::.|.:.||.|.|    :
Zfish   717 PEGSLILNTKSDESSLIISQISTPV-----TLTVQ------PCEKDSEQNIGSPEQPNTGISKKD 770

  Fly   126 QELKLDDEELNGQIKLD-DEVLKLADKQIN-----ENLPFADEVDAKAEQKLMDEELQQVVEELL 184
            ...|....::.||:..: ....||.:..:.     :.:.|:|.......|||..|...:...|:.
Zfish   771 ASAKKSRWDIVGQVTSEYQSPAKLVNPDVKKVMLAQKIEFSDTTPDNCSQKLDPEVPSEKSVEVH 835

  Fly   185 FDGSSRASSN---SPFYQ-------HDMDVMQEIQQTPEIPHIKKVTEPLEGLGSLADFQTHRSA 239
            ...::.|.|:   |.|..       ||     |:|:|.|||   :.|..|    .::|||..:..
Zfish   836 ARDTTAAESHQEISSFTSNFGTKGTHD-----ELQKTVEIP---QSTSAL----VVSDFQPSKEK 888

  Fly   240 LR-----------------------DSHSSTHSSSTDN------------IFLQEPVLTLDID-- 267
            :.                       ||.|....|.:|:            :..:...:.|:.:
Zfish   889 VNVDKTKPEIQDPDSLNHDGKCHSDDSESEESDSDSDDGRVSLKRLHSVVVVPKNSTIALETNDK 953

  Fly   268 RTPTKASSI-----------KINRSF-----------ELAGAVFS-------SPPSVLNACLNGR 303
            ..|..|||:           .||:.|           |.:.|::.       ..|:|.......:
Zfish   954 AEPAPASSLFSGNQQTDTHESINKEFPYGFNNQSTLKESSAALYKGSAQAACQSPNVKGVSYQSQ 1018

  Fly   304 FNQIVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGLTANTESP--AGQPRR----------RKP 356
            .|.:.|.:    .|::....:|::.|:.             |.|  :||..:          .||
Zfish  1019 SNMVDSTS----HLEVMSAHVDKNWSAQ-------------ERPNISGQINQEYVQNFEKTCEKP 1066

  Fly   357 ATPHRILCPSPIKTALKVTGGICKVGSADPLSPRKSPRKLPTTTAAVAACKSRRRLNQPKP---- 417
            .|.|......|  .:.....|...||..|.|....:..:.|::|..    :.....:.|:|
Zfish  1067 ETDHHQYHGRP--DSWNGRKGDFSVGRGDSLVWDFNQSEQPSSTFQ----QPDSSYSTPQPLFDS 1125

  Fly   418 ---QAPY-QPQLQKPPSQQQQQ---QQDDIVVVLDDDDDEGDDEDDVRA---------------- 459
               :.|: ||.:.|........   |..|:|..:..|....|.:||...
Zfish  1126 VHREDPWAQPAISKTSRTVNTHVPFQYHDLVHQIHPDSLTNDHDDDREGRILGIKQASLLSAGLP 1190

  Fly   460 ----LIKAAE---------ERENQNKAP-----------------------ATANSNKAGMKTM- 487
                .::|.|         |.:|.::||                       .:.|..:||:...
Zfish  1191 GPSPFVQAPEISSNCSFTTESQNISEAPRDDNQKPHRGRGPPKKRRQEFESESDNEAEAGLSKRE 1255

  Fly   488 --------LKPA------------PVKSKT--------KSKGPTKGQPP--------LPLAATNG 516
                    ||.|            |:.|..        :.|...|..||        |.|.....
Zfish  1256 CFDESSRPLKDAKESFHQIQEVQRPLLSLKEFSDPFVWRDKAKQKKMPPYFDLIEENLYLTERKK 1320

  Fly   517 NREMTDFFPVRRSVRKTKTAVKEEWMRG--------LEQAVLEE---RC-DGLQV--RHFM---- 563
            |:...|   ::|...:.....|||..||        |.:.::.|   || :|...  |.|.
Zfish  1321 NKSHRD---IKRMQCECAILSKEERARGILACGEDCLNRLLMIECSSRCLNGAYCSNRRFQMKQH 1382

  Fly   564 ---------GKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQ 619
                     .||.|:.|.:..:.|.||:||.|:::...|...|.|.||.::|   ..|||.....
Zfish  1383 ADYEVILTESKGWGLRAAKDLQPNTFVLEYCGEVLDHREFKARVKEYARNKN---IHYYFMALKN 1444

  Fly   620 QYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
            ...||||: .|...|.:|||...|..|:...:..:..:.......:..|.|||:||
Zfish  1445 NEIIDATL-KGNCSRFMNHSCEPNCETQKWTVNGQLRIGFFTTKAVTAGTELTFDY 1499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	47/164 (29%)
setd2	XP_009290459.2	None