DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set8 and KMT2C

DIOPT Version :10

Sequence 1:NP_650354.1 Gene:Set8 / 41743 FlyBaseID:FBgn0011474 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_733751.2 Gene:KMT2C / 58508 HGNCID:13726 Length:4911 Species:Homo sapiens


Alignment Length:192 Identity:55/192 - (28%)
Similarity:89/192 - (46%) Gaps:31/192 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   487 MLKPAPVKSKTKSK---GPTKGQPPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWMRGLEQA 548
            :|:|..:.|.:.||   ....|:...|.:....:.:.:.:       ||.||    ||...:..|
Human  4723 VLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQY-------RKMKT----EWKSNVYLA 4776

  Fly   549 VLEERCDGLQVRHFMGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYY 613
              ..|..||          |:.|.|..:::..|:||:|.:|. .|.|.|:::....:|.|.||: 
Human  4777 --RSRIQGL----------GLYAARDIEKHTMVIEYIGTIIR-NEVANRKEKLYESQNRGVYMF- 4827

  Fly   614 FKHKSQQYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
              .....:.||||: ||...|.||||.|.|.:.:||..::...:::.:...|:.||||.|||
Human  4828 --RMDNDHVIDATL-TGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDY 4886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set8NP_650354.1 SET_SETD8 539..678 CDD:380926 44/137 (32%)
KMT2CNP_733751.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..203
ePHD1_KMT2C 247..330 CDD:277166
PHD1_KMT2C_like 343..388 CDD:276984
PHD2_KMT2C 390..435 CDD:277069
PHD3_KMT2C 466..517 CDD:276986
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..742
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..798
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 828..864
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 885..912
PHD4_KMT2C 952..1008 CDD:277071
PHD5_KMT2C_like 1009..1055 CDD:276988
RanBP2-type Zn finger 1084..1106 CDD:275375
PHD6_KMT2C 1086..1136 CDD:277073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1215..1324
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1406..1431
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1458..1485
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1630
HMG-box_KMT2C 1633..1713 CDD:438835
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1709..2448
PHA03247 <1876..2353 CDD:223021
Atrophin-1 2219..>2547 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2589..2694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2793..2887
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2925..2954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2989..3029
TPH <3176..>3272 CDD:464007
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3205..3241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3353..3409
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3527..3583
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3596..3919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4024..4053
ePHD2_KMT2C 4402..4506 CDD:277167
FYRN 4551..4602 CDD:461787
FYRC 4610..4697 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 4707..4712
SET_KMT2C_2D 4758..4910 CDD:380948 48/157 (31%)
Blue background indicates that the domain is not in the aligned region.

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