Protein Alignment Set8 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: XP_063121507.1
• Gene: Kmt2a / 315606
• RGDID: 1586165
• Length: 4017
• Species: Rattus norvegicus
• Alignment Length: 635
• Identity: 149/635 - (23%)
• Similarity: 231/635 - (36%)
• Gaps: 169/635 - (26%)

  Fly   188 SSRASSNSPFYQHDMDVMQEIQQTPEIP-HIKKVTEPLEG---LGSLADF---QTHRS-ALRDSH 244
            |:.||.:|......|........:..:| |:....:.|.|   :||::..   .:|:| .::|..
  Rat  3380 SALASGSSVLNVVSMQTTTTPTSSTSVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQP 3444

  Fly   245 SSTHSSSTDNIFLQEPVLTLDIDRTP-----TKASSIKINRSFELAGAVFSSPP---------SV 295
            .:...||  .:|.|     |...:||     |.||||.:..|.:.||...:|||         ..
  Rat  3445 VALPQSS--GMFPQ-----LGTSQTPSAAAMTAASSICVLPSSQTAGMTAASPPREAEEQYKLQR 3502

  Fly   296 LNACLNGR----------------------FNQIVSL-NGQK--EALDLPHFDLDQHDSSSCDSG 335
            :|..|.|:                      |.|.... ||.:  :...||  ...|..|:|..|.
  Rat  3503 VNQLLAGKTGTLSLQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLP--SAKQASSTSPGSS 3565

  Fly   336 VACGLTANTESPAGQPRRRKPATPHRILCPSPIKTALKVTGGICKVG-------------SADPL 387
            .:.|..:.:.|..| |.:.||.. .||..|..     |.:|...||.             .|:|
  Rat  3566 PSSGQQSGSSSVPG-PTKPKPKV-KRIQLPLD-----KGSGKKHKVSHLRTSSEAHIPHREANP- 3622

  Fly   388 SPRKSPRKLPTT-----TAAVAACKSRRRLNQPKPQAPYQPQLQ------------KPPS----- 430
            :|:.|.::.|..     .||.....|::...||...|...|::|            :|.:
  Rat  3623 APQPSVKRTPRADREQQEAAGVEQPSQKECGQPAGPATALPEIQATQNPANEQENAEPKAVEEEE 3687

  Fly   431 -----------QQQQQQQDDIV-------VVLDDDDDEG------DDEDDVRALI-KAAEERENQ 470
                       ||:|::::.|.       :|.:...|:|      ..||..::|. |..|.|.|.
  Rat  3688 SSFSSPLMLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNA 3752

  Fly   471 N-KAPATANSNKAGMKTMLKPAPV-------------KSKTKSKGPTK-GQPPL-----PLAATN 515
            . |..:.|..|...|..:|..|.|             ..|.:...|.: .:|||     ..|..:
  Rat  3753 RLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH 3817

  Fly   516 GNREMTDFFPVRRSVRK-------TKTAVKEEWMRGLEQAVLEERCDGLQVRHF-------MG-- 564
            ..:...|.|....|..:       .....:|..::...:|...:....::.||.       :|
  Rat  3818 LRQSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVY 3882

  Fly   565 ----KGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDA 625
                .|||:...|.....|.|:||.|::|...:..:|||.|. .:..||||:..   .....:||
  Rat  3883 RSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYD-SKGIGCYMFRI---DDSEVVDA 3943

  Fly   626 TVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
            |:. |...|.||||...|..::|:.|..:.|:|:.|...|..||||||||
  Rat  3944 TMH-GNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDY 3992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	47/150 (31%)
Kmt2a	XP_063121507.1	None