Protein Alignment Set8 and G9a

DIOPT Version :10

• Sequence 1: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 118/597 - (19%)
• Similarity: 206/597 - (34%)
• Gaps: 203/597 - (34%)

  Fly    80 KAGRTIGVPLATRSQTRTIENFFKANAAAKDSQ-KTIHTEEQLNLGNQE---------------- 127
            :.|..:.:.|| ..:|....|......|:|:.: |....||:....|||
  Fly    25 EGGTLLNLNLA-EDKTLKWRNLANNQFASKEKKHKDKEEEERKEARNQEEIEDIKALLADVVDAA 88

  Fly   128 -LKLDDEELNGQIKLDDEVLKLADKQINENLPFADEV---DAKAEQKLMDEELQQVVEELLFDGS 188
             :||::||.....|::.......:::..:.:.:..:|   |::.|:|...:.....|:   .:.:
  Fly    89 AVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEMEKKQNGKATSITVK---MESN 150

  Fly   189 SRASSNSPFYQHDMDVMQEIQQTPEIPHIKKVTEPLEGLGSLADFQTHRSALRDSHSSTHSSSTD 253
            .||..::          .||..|.        ||..|......:.|..::|.::
  Fly   151 ERAEKHA----------TEIATTS--------TERWENESFKTEQQNKKAAEKE----------- 186

  Fly   254 NIFLQEPVLT----LDIDRTPTKASSIKINRSFELAGAVFSSPPSVLNACLNGRFNQIVSLNGQK 314
                :||:|.    |:.:..|...:.|::         ..:||             .:||....|
  Fly   187 ----EEPILAATQKLEANAEPLTTTRIEV---------AVASP-------------LVVSSASVK 225

  Fly   315 EALDLPHFDLDQHDSSSCDSGVACGLTANTE-SPAGQPRRRKPATPHRILCPSPIKTALKVTGGI 378
            .|.|..:     ...::..:|.|.....|.: ||.|..|.|:        .|.||.|...||...
  Fly   226 LAADATN-----QMRAATSAGAATLADKNVQVSPGGTRRSRR--------TPRPIDTPTSVTDEH 277

  Fly   379 CKV-----GSADP---------------------LSPRKSPRKLPTTTA-------AVAACKSRR 410
            .:|     |.::.                     |..:..|.| |:.||       |.|..:.|.
  Fly   278 VQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDK-PSLTALSPEENSAPAPKRGRG 341

  Fly   411 RLNQPKPQA---------PYQPQL-QKPPSQQQ--------QQQQDDIVVVLDDDDDEGDDE-DD 456
            |..:.:|.|         |.:..| :|.|.:::        |||..|:|||..:.::.||.. .|
  Fly   342 RARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGD 406

  Fly   457 VRALIKAA-------------EERENQNKAP-ATANSNKAGMKTMLKPAPV---KSKTKSKGPTK 504
            |:.:.::.             ||.:.:...| .:|..:.|.:.:.:.|..|   |:..|.:| .|
  Fly   407 VKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPPKKRG-RK 470

  Fly   505 GQPP-----------LPLAATNGNREMTDF------FPVRRSVRKTKTAVKEEWMRGLEQAVLEE 552
            .:.|           ||.|  |||::....      .| :||.|:.|...|          :||.
  Fly   471 AKTPCVKLESETSCGLPFA--NGNKKTNSSGGCELQLP-KRSKRRIKPTPK----------ILEN 522

  Fly   553 ---RCDGLQVRH 561
               ||: .:.:|
  Fly   523 DELRCE-FETKH 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	5/26 (19%)
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	23/155 (15%)
		EHMT_ZBD	786..933	CDD:411018
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941