Protein Alignment Set8 and Nsd1

DIOPT Version :10

• Sequence 1: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001388465.1
• Gene: Nsd1 / 306764
• RGDID: 1307748
• Length: 2689
• Species: Rattus norvegicus
• Alignment Length: 951
• Identity: 174/951 - (18%)
• Similarity: 290/951 - (30%)
• Gaps: 336/951 - (35%)

  Fly     5 RRRQRPAKEAASSSSGGASSGS------GIPV--------DQALPLNVAGNLLEDQYFASPK--- 52
            :||.:|.|.|:.......|.|:      |.||        :|..|   ..::|||. .|.|.
  Rat  1162 QRRPKPGKRASRFREKENSEGAFGVLLPGDPVQKGRDDYLEQRAP---PTSILEDS-AADPNHVS 1222

  Fly    53 ----------------------RKDCRLMKVTQNGQLPEATMMAHNKD-NKAGRTIGVPLATRSQ 94
                                  .|:..:..:|...::||..:.:..|. .|..:.:      ...
  Rat  1223 HSESVGPRLNVCDKSSVSMGDLEKETGIPSLTPQTKIPEPAVRSEKKRLRKPSKWL------LEY 1281

  Fly    95 TRTIENFFKANAAAKDSQKTIHTEEQLNLGNQELKLDDEEL------NGQIKLDDEVLKLADKQ- 152
            |...:..|    |.|..||.:  :||::  ....:.:||.|      :.|.|..||...::.|:
  Rat  1282 TEEYDQIF----APKKKQKKV--QEQVH--KVSSRCEDESLLARCRSSAQNKQVDENSLISTKEE 1338

  Fly   153 ---INENLPFADEVDAKAEQKLMDEELQQVV-----------------EELL------FDGS-SR 190
               :....||.:....:::..:...||.|:.                 ||||      ::|. .|
  Rat  1339 PPVLEREAPFLEGPLVQSDLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGNYEGKRQR 1403

  Fly   191 ASSNSPFYQHDMD---------------------VMQEIQQTPEIPHIKKVTEPLEGLGSLADFQ 234
            ..:......:|:|                     :...:..:...||:|:.     |.|:...|.
  Rat  1404 KPTKKLLESNDLDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEF-----GGGTTRIFD 1463

  Fly   235 THRSALRDSHSS----------------THSSSTDNIFLQ------EPVLTLDIDRTPTKASSIK 277
            ..|...|..|.:                |.||:...:.:.      :.:|...|:..|..::|.:
  Rat  1464 KPRKRKRQRHGTARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGIEHDPGMSASKR 1528

  Fly   278 INRSFELAGAVFSSPPSVLNACLN-GRFNQIVSLNGQ------KEALDLPHFDLDQHDSSSCDSG 335
            : :.....||....     |.|.| .:..:::....|      .|.|.|......:...:.|.:|
  Rat  1529 L-QGERGGGAALKE-----NVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTG 1587

  Fly   336 V-------------------ACG----------------------------LTANTESPA----- 348
            :                   .||                            :|.:..:||
  Rat  1588 IHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVVQNKGFRCPLHICITCHAANPANVSAS 1652

  Fly   349 -GQPRR--RKPATPH----------RILCPSPIKTALKVTGGICKVGSADPLSPRKSPRK----- 395
             |:..|  |.|...|          :||..:.|         ||    .:..:||:..|.
  Rat  1653 KGRLMRCVRCPVAYHANDFCLAAGSKILASNSI---------IC----PNHFTPRRGCRNHEHVN 1704

  Fly   396 -----LPTTTAAVAACKS------RRRLNQPKPQA------------PYQPQL------------ 425
                 :.:...::..|.|      |..||...|:.            |:..::
  Rat  1705 VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWP 1769

  Fly   426 ------QKPPSQQQQQQQD--DIVVVLDDDDD-------------EGD-----------DEDDVR 458
                  :..||...:.:.|  :..|:....:|             |||           |....:
  Rat  1770 AEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKK 1834

  Fly   459 ALIKAAEERENQNKAPATANSNKAGMKTMLKPAPVKSKTKSKGP-------TKGQPPLPLAATNG 516
            ||.:|| .|..:.||.......:...|...||.|.| ..|...|       |.....:|..
  Rat  1835 ALQEAA-ARFEELKAQKELRQLQEDRKNDKKPPPYK-HIKVNRPIGRVQIFTADLSEIPRC---- 1893

  Fly   517 NREMTDFFPV--------RRSVRKTKTAVKEEWMRGLEQAVLEERCDGLQVRHFMGKGRGVVADR 573
            |.:.||..|.        |..:.:....|.....|...|...:.:...:::...:.:|.|:....
  Rat  1894 NCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKT 1958

  Fly   574 PFKRNEFVVEYVGDLISIGEAAEREKRYALDEN-AGCYMYYFKHKSQQYCIDATVDTGKLG---R 634
            ..|:.|||.||||:||...|...| .|||.:.: ...||.....       |..:|.|..|   |
  Rat  1959 DIKKGEFVNEYVGELIDEEECRAR-IRYAQEHDITNFYMLTLDK-------DRIIDAGPKGNYAR 2015

  Fly   635 LINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
            .:||....|..|:...:.....:.|.|..||:.|.|||::|
  Rat  2016 FMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNY 2056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	39/141 (28%)
Nsd1	NP_001388465.1	PWWP_NSD1_rpt1	318..433	CDD:438989
		TNG2	<1452..1585	CDD:227367	23/143 (16%)
		PHD1_NSD1_2	1543..1585	CDD:277118	6/41 (15%)
		PHD2_NSD1	1590..1636	CDD:277120	2/45 (4%)
		PHD3_NSD1	1637..1690	CDD:277123	13/65 (20%)
		PHD4_NSD1	1707..1746	CDD:277126	6/38 (16%)
		PWWP_NSD1_rpt2	1753..1848	CDD:438992	14/95 (15%)
		AWS	1899..1937	CDD:465559	6/37 (16%)
		SET_NSD1	1939..2080	CDD:380987	37/126 (29%)
		PHD5_NSD1	2118..2160	CDD:277129
		C5HCH	2159..2208	CDD:465605
		PHA03247	<2221..2593	CDD:223021