DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PR-Set7 and set1

DIOPT Version :9

Sequence 1:	NP_001247100.1	Gene:	PR-Set7 / 41743	FlyBaseID:	FBgn0011474	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_587812.1	Gene:	set1 / 2538762	PomBaseID:	SPCC306.04c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	771	Identity:	174/771 - (22%)
Similarity:	285/771 - (36%)	Gaps:	207/771 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QRPAKEAASSSSGGASSGSGIPVDQA----------LPLNVAG--NLLEDQYFASPKRKDCRLMK 60
            ::|:|.:.:.|:|.........|||.          :|.|:..  .||.|..|..|.|.....:|
pombe   231 RQPSKNSQTLSNGDLQHSKVQNVDQKSGFLTSSETDVPKNINDYIYLLIDDRFVPPDRVYYTDIK 295

  Fly    61 VTQNGQLPEATMMAHNKDNKAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQLNLGN 125
            ......|.|...|     ||.|..|           |..|:.:|:...:...:|.       :.|
pombe   296 HHFRKFLYEKIYM-----NKDGFYI-----------TFNNYREASNCYRALDRTY-------VQN 337

  Fly   126 QELKLDDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVVEELLFDGSSR 190
            ..:||...::..:.|.|.:  |.|.:::  .|| .:|..|:|...:    |:.:...||.|..|:
pombe   338 CRIKLKFHDIPSRTKEDGK--KSAVRRV--VLP-PEEAYAEATSVV----LRDLEAALLRDVKSK 393

  Fly   191 ASSNSPF-YQHDM---DVMQEIQQ--------TPEIPHIKKVTEPLEGLGSLADF---------- 233
            ....:.| |.|.|   .|.:|:|:        .|::|  .|:...:..|.||..|
pombe   394 IIGPAIFKYLHSMPKPSVKEELQENLLVSSTSVPDVP--LKIESTVGKLPSLPKFKKRVDSSKMN 456

  Fly   234 --------------QTHRSALRDSH--------SSTHSSSTDNIFLQEPVLTLDIDRTPT-KASS 275
                          :..|...|..|        ||...:.:|    ||.:|:...:|... |..|
pombe   457 LSAGSKTKSKLQRRRRRRHEARPLHYQLNQMYNSSASEAESD----QELLLSSGDERVERGKIGS 517

  Fly   276 IKINRSFELAGAVFSSPPSVLNACLNGRFNQIVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGL 340
            ||..:|.| |..|||.....     |.:|::..:    |..:....::..:.|.:|
pombe   518 IKSVKSDE-ATPVFSDTSDE-----NDKFHRFRT----KSKISKKKYEKMEVDYTS--------- 563

  Fly   341 TANTESPAGQPRRRKPATPHRILCPSPIKTALKVTGGICKVGSA---DPLSPRKSPRKLPTTTAA 402
            ::.|||.|.            ||.||         ..|.|.|||   :.:||:|.       ...
pombe   564 SSETESDAS------------ILSPS---------AAIPKSGSAIKDELISPKKE-------IDE 600

  Fly   403 VAACKSRRRLNQ-PKPQAPYQPQLQKPPSQQQQQQQDDIVVVLDDDDDEGDDEDDVRALIKAAEE 466
            |.|...:.|:|: .:..:.|...|      .....:||:::.||.......:::|...|.:|.::
pombe   601 VLALAPKWRINEFDETGSVYYGAL------PYNYPEDDVLLDLDGLQYLVKNDEDYSYLQEALKD 659

  Fly   467 R-----------ENQNKAPATANSNKAGMKTMLKPAP---VKSKTKSKGPTKGQPPLPLAATNGN 517
            .           ..:.|:....|.:.....|.:.|.|   .:|.|.....::|...:|      .
pombe   660 EPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEPKGYFRSNTSGSAKSEGYYIIP------T 718

  Fly   518 REMTDFFPVRRSVRKTKTAVKEEWMR---------------GLEQAVLEERCD-----GLQVR-- 560
            .|.:.:.|:|.  |.|...:.....|               |:|::.|....|     .|:.|
pombe   719 TEKSLYLPLRN--RSTIDTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRFNALKARKK 781

  Fly   561 --HFMGKGR----GVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQ 619
              || |..|    |:.|.....:|:.|:||:|::|....|..|||.|..:.....|::..   .:
pombe   782 QLHF-GPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNREKNYVREGIGDSYLFRI---DE 842

  Fly   620 QYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
            ...:||| ..|.:.|.||||.|.|.:.:::.::.:..:|:.|..||..||||||||
pombe   843 DVIVDAT-KKGNIARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMHGEELTYDY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PR-Set7	NP_001247100.1	SET	566..676	CDD:279228	38/114 (33%)
set1	NP_587812.1	RRM	<90..>226	CDD:223796
		RRM_spSet1p_like	96..180	CDD:240749
		SET_assoc	279..342	CDD:288600	17/85 (20%)
		SET	457..920	CDD:225491	116/511 (23%)
		N-SET	641..771	CDD:288597	22/137 (16%)
		SET	783..899	CDD:214614	41/120 (34%)
		PostSET	904..920	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910