Protein Alignment Set8 and Ezh2

DIOPT Version :10

• Sequence 1: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001396739.1
• Gene: Ezh2 / 14056
• MGIID: 107940
• Length: 751
• Species: Mus musculus
• Alignment Length: 764
• Identity: 157/764 - (20%)
• Similarity: 257/764 - (33%)
• Gaps: 187/764 - (24%)

  Fly     5 RRRQRPAKEAASSSSGGASSGSGIPVD-----QALPLNVAGNL--LEDQYFASPKRKDCRLMKVT 62
            :||.:|.....|.||...:....:..|     |.:||.....:  :...|..||         :.
Mouse    62 QRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSP---------LQ 117

  Fly    63 QNGQLPEATMMAHNKDNKAGRTIGVPLATRSQTRT-IENFFKANAAAKDSQKTIHTEEQLNLGNQ 126
            ||..:.:.|:: ||........:       .|..| ||...| |...|     :|.:.:....|.
Mouse   118 QNFMVEDETVL-HNIPYMGDEVL-------DQDGTFIEELIK-NYDGK-----VHGDRECGFIND 168

  Fly   127 ELKL-----------DDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVV 180
            |:.:           ||::.:|.   |.:..:...|.:.:|   .|:.:....:|...:::.:.:
Mouse   169 EIFVELVNALGQYNDDDDDDDGD---DPDEREEKQKDLEDN---RDDKETCPPRKFPADKIFEAI 227

  Fly   181 EELLFDGSSRASSNSPFYQHDMDVMQEI------QQTPEI--PHIKKVTEPLEGLGSLADFQT-- 235
            .. :|.....|......|:...:  |::      :.||.|  |:.|.|...    .||..|.|
Mouse   228 SS-MFPDKGTAEELKEKYKELTE--QQLPGALPPECTPNIDGPNAKSVQRE----QSLHSFHTLF 285

  Fly   236 -----------HRSALRDSHSSTHSSSTDNIFLQEPVLTLDIDRTPTKASSIK-INRSFELAGAV 288
                       ||......|      :|.|.:.::...|. :|..|......: :..:.|.|.|:
Mouse   286 CRRCFKYDCFLHRKCSYSFH------ATPNTYKRKNTETA-LDNKPCGPQCYQHLEGAKEFAAAL 343

  Fly   289 ----FSSPPSVLNACLNGRF--------NQIVSLNGQK--------------EALDLPHFDLDQH 327
                ..:||........||.        ...:|:...|              |..|....:....
Mouse   344 TAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDE 408

  Fly   328 DSSSCDSGVAC----GLTANTESPAGQPRRRKPATPHRIL-------------------CPSPIK 369
            .|||.::...|    .:..|.|.|.........|:..|:|                   |....:
Mouse   409 TSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYE 473

  Fly   370 TALKVTGGICKVGSAD-PLSPRKSPRKLPTTTAAVAACKSRRRLNQPKPQAPYQPQLQKPPSQQQ 433
            ..:|.:..|..|.:.| ...|||..||   .....|.|   |::...|..:.......:|....:
Mouse   474 FRVKESSIIAPVPTEDVDTPPRKKKRK---HRLWAAHC---RKIQLKKDGSSNHVYNYQPCDHPR 532

  Fly   434 QQQQDDIVVVLDDDDDEGDDEDDVRALIKAAE-ERENQNKAPATANSNKAGMKTMLKPAPVKSKT 497
            |........|:..:..|           |..: ..|.||:.|..  ..||...|  |..|.....
Mouse   533 QPCDSSCPCVIAQNFCE-----------KFCQCSSECQNRFPGC--RCKAQCNT--KQCPCYLAV 582

  Fly   498 KSKGPTKGQPPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWMRGLEQAVLEERCDGLQVRHF 562
            :...|       .|..|.|..:..|    .::|.....:::    ||.::.:|....|
Mouse   583 RECDP-------DLCLTCGAADHWD----SKNVSCKNCSIQ----RGSKKHLLLAPSD------- 625

  Fly   563 MGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFK-HKSQQYCIDAT 626
             ..|.|:....|.::|||:.||.|::||..||..|.|.|  |:    ||..|. :.:..:.:|||
Mouse   626 -VAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DK----YMCSFLFNLNNDFVVDAT 683

  Fly   627 VDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675
            ....|: |..|||...|...||:::.....:.:.||..|:.||||.:||
Mouse   684 RKGNKI-RFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	44/138 (32%)
Ezh2	NP_001396739.1	Interaction with EED	39..68		2/5 (40%)
		EZH2_WD-Binding	39..68	CDD:463308	2/5 (40%)
		PRC2_HTH_1	158..249	CDD:436286	14/97 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..217		7/42 (17%)
		Interaction with CDYL. /evidence=ECO:0000250	334..527		35/198 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..431		13/85 (15%)
		preSET_CXC	564..595	CDD:408079	8/41 (20%)
		SET_EZH2	614..733	CDD:380995	43/133 (32%)