DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and AZF1

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	774	Identity:	163/774 - (21%)
Similarity:	259/774 - (33%)	Gaps:	194/774 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSV 66
            |:.:|....:..||    |.....|..:.......::....|.|:...|.|:.:.||:.....|.
Yeast   222 SSRRESNSMRPPLL----IPAATTKSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQNPYFLSS 282

  Fly    67 AGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKM 131
            ..:.:| .|.|........:....:.|...:|....:.|.:..|.:|    ..|....|     :
Yeast   283 RNNSLK-FNPEDFDFQFKRRNSFVRGTLDHSSQNAFIPESRLNSLSV----NNKANGDP-----V 337

  Fly   132 EHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDG 196
            ...|...:|.::.:.|.                 ||.........|||      ..::.:...|.
Yeast   338 ADNVTNNMKGKSNEVDN-----------------DDGNDSSNNNNNNN------NNNNNENNNDN 379

  Fly   197 DEDGEDSSGKGNSSQTKIKEIVEH------VCGKCYKTFRRV-QSLKKHL-EFCRYDSGYH--LR 251
            :.|..|:| ..:::.|.|....:|      ......|..:.: |.|:||| :...|.|...  |.
Yeast   380 NNDNNDNS-INSATSTNIPNQEDHSLASTDTTSNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLD 443

  Fly   252 KADMLKNLEKIEK---------DAVVMEKKD--ICFCCSESYDTFHLGHINCPDCPKSFKTQTSY 305
            |.|:::..|.:.|         :.:...|||  ..:..:|...|         |.|.|....||.
Yeast   444 KNDVIEGSEGLNKHIDESGMQPNIIKKRKKDDSTVYVKNEMPRT---------DPPMSKDNSTSA 499

  Fly   306 ERHIFITH----------SEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRS 360
            |.......          |..||...::..|....:.:|.:...:              |.||..
Yeast   500 EGAAMANFSGKEPPIPDISSVSDDATNLIGATKVDQLMLIIQARK--------------KGFTEK 550

  Fly   361 YHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQ---VVKKPEYMCHTCKNCF 422
            .:          ::.:.|.:..:..| :......|...:::..|||   .|||.|  |..|...|
Yeast   551 VN----------TTQDGDLLFNQTMD-ILPPKSELVGGVEKPKGTQNTRAVKKHE--CPYCHRLF 602

  Fly   423 YSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRH 487
            ...:.|.:|:|:|.|.|||.||.|.|:|:....|:.|.|.|||||||||.:|::.|:.|..|..|
Yeast   603 SQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAH 667

  Fly   488 MKRHTGERPHKC--DECGKSFIQ-----ATQLRTHSKT---------HIRP---FPCE--QCDEK 531
            :..|...:|..|  :.|.|:|.|     |.|.|.|.:|         .:.|   .|.|  |..|.
Yeast   668 LVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEY 732

  Fly   532 FKT-EKQLERHVKTHSR---TKRPVFSCAECKRNFRTPALL--------------------KEHM 572
            |.: .|...|.:|...:   ||:...|..|   |.....:|                    :.::
Yeast   733 FASIYKNSNRGIKGRGKGVGTKKSTISSPE---NHPASTILNPNTNANNAIANDSENNGNPEGNI 794

  Fly   573 DEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDD------IFGVEP 631
            |...:|.....|.:....|.|..........||::|         |:..:|.:      .:...|
Yeast   795 DSSSNSNPGSHSMISPTQKDMGTLQSQFIQNNFNNS---------VNSSNPSNQPIINYNYTTLP 850

  Fly   632 HPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENE 690
            |                    :..||..||.|:.|.   ..|.|....|.....|..|:
Yeast   851 H--------------------SRLGSSSSSNTNNNN---SNFSVGAAPGVLMAPTTNND 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	62/224 (28%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		zf-C2H2	348..368	CDD:278523	3/19 (16%)
		C2H2 Zn finger	350..368	CDD:275368	3/17 (18%)
		C2H2 Zn finger	382..402	CDD:275368	2/19 (11%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	12/22 (55%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..479	CDD:290200	13/23 (57%)
		COG5048	<467..620	CDD:227381	46/197 (23%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	8/25 (32%)
		C2H2 Zn finger	499..519	CDD:275368	10/35 (29%)
		C2H2 Zn finger	525..545	CDD:275368	7/22 (32%)
		C2H2 Zn finger	555..572	CDD:275368	3/36 (8%)
		C2H2 Zn finger	598..615	CDD:275371	3/16 (19%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	115/488 (24%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		C2H2 Zn finger	679..702	CDD:275368	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010