DRSC/TRiP Functional Genomics Resources

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Protein Alignment su(Hw) and ZNF148

DIOPT Version :9

Sequence 1:NP_001247098.1 Gene:su(Hw) / 41740 FlyBaseID:FBgn0003567 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001335353.1 Gene:ZNF148 / 7707 HGNCID:12933 Length:794 Species:Homo sapiens


Alignment Length:622 Identity:139/622 - (22%)
Similarity:221/622 - (35%) Gaps:170/622 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   425 LSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMK 489
            |.|...|:          |:.|:..|.....|::|...||||||:.|:.|:..|..|.:|.||.|
Human   165 LKTPKSHV----------CEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEK 219

  Fly   490 RHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKF-KTEKQLERHVKTHSRTKRP 551
            .||||:|.:|||||..|||...:..|.:||.  :|:.||.|.:.| :|::.|:.....|....:.
Human   220 IHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKK 284

  Fly   552 VFSCAECKRNFRTPALLKEHMDEG-KHSPK------------QQRSSMRSAVKIMERTDCAICDK 603
            :..||      ....||....|.| ..|||            :::||.......::::|.. .||
Human   285 LNRCA------IKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLK-KDK 342

  Fly   604 N-----FDSSDTLRRHI-----------RTVHECDPDDIFGVEPHPSKRAKKDIESEEVV--PVA 650
            |     :.||..::...           .:|.....:|..| |.||.|...|.|.|:..:  |:.
Human   343 NDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASG-EIHPPKLVLKKINSKRSLKQPLE 406

  Fly   651 LNTSAGSLISSQTDGNGVVVREF-LVDEGDGAAQTITLENETYTILPLDGAIEGEQLTD--EAGV 712
            .|.:...|  |..:.:.|....| |||:              ..:|..:|..:.:|:.:  |...
Human   407 QNQTISPL--STYEESKVSKYAFELVDK--------------QALLDSEGNADIDQVDNLQEGPS 455

  Fly   713 KPEAKKEEAQVSPVVKKEQRKSLAAS-------------------LAAAIADNLEESCSEDDFSG 758
            ||.........:....|::|...|||                   ..||:|..::||.:......
Human   456 KPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILES 520

  Fly   759 EILTEEDIKLKENVGK------LIDMLVDPPILKKYGW--------------------PNAPEET 797
            :.|   ::::|.|..|      ::..|:|....|..|.                    ...||.|
Human   521 QAL---NVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVT 582

  Fly   798 VLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLN----NFPIDD---- 854
                ..||.|     .....:..|..:.::||.|.|...:.......:.||    ||..|:    
Human   583 ----PSENVG-----SSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLP 638

  Fly   855 -----------------VIEYVLG-------DEDQDEGGLDKDNESH----SGDEEAVSVTGETK 891
                             :..:..|       ..|:...||...:..|    ||||  .:....|.
Human   639 NQPAFSSIDKQVYATMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDE--TNHASATS 701

  Fly   892 TNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVR 928
            |.:..:    :..|.|..:.:.|.:|....:.|:..|
Human   702 TQDFLD----QVTSQKKAEAQPVHQAYQMSSFEQPFR 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
su(Hw)NP_001247098.1 C2H2 Zn finger 292..313 CDD:275368
COG5048 <312..517 CDD:227381 36/91 (40%)
C2H2 Zn finger 321..341 CDD:275368
zf-C2H2 348..368 CDD:278523
C2H2 Zn finger 350..368 CDD:275368
C2H2 Zn finger 382..402 CDD:275368
C2H2 Zn finger 415..435 CDD:275368 3/9 (33%)
zf-H2C2_2 428..451 CDD:290200 3/22 (14%)
C2H2 Zn finger 443..463 CDD:275368 5/19 (26%)
zf-H2C2_2 455..479 CDD:290200 10/23 (43%)
COG5048 <467..620 CDD:227381 52/184 (28%)
C2H2 Zn finger 471..491 CDD:275368 8/19 (42%)
zf-H2C2_2 484..508 CDD:290200 15/23 (65%)
C2H2 Zn finger 499..519 CDD:275368 9/19 (47%)
C2H2 Zn finger 525..545 CDD:275368 6/20 (30%)
C2H2 Zn finger 555..572 CDD:275368 4/16 (25%)
C2H2 Zn finger 598..615 CDD:275371 5/21 (24%)
ZNF148NP_001335353.1 zf-C2H2 171..193 CDD:395048 6/31 (19%)
C2H2 Zn finger 173..193 CDD:275368 5/19 (26%)
zf-H2C2_2 185..210 CDD:404364 11/24 (46%)
C2H2 Zn finger 201..221 CDD:275368 8/19 (42%)
zf-H2C2_2 214..238 CDD:404364 15/23 (65%)
C2H2 Zn finger 229..249 CDD:275368 9/19 (47%)
zf-H2C2_2 241..266 CDD:404364 8/24 (33%)
C2H2 Zn finger 257..275 CDD:275368 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..336 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..596 6/30 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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