DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and E4f1

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001171975.1	Gene:	E4f1 / 681359	RGDID:	1596731	Length:	783	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	171/897 - (19%)
Similarity:	299/897 - (33%)	Gaps:	312/897 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 TTTSRTPSNKQEKRGSVAGSRIKILNEEILGTP-------------------------------- 82
            |..:|..:..:...|.||.: ..:.|...||.|
  Rat    14 TAEARAEAGHEAGEGGVAAA-AALSNGGFLGLPAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKI 77

  Fly    83 -KTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKA 146
             ||..|...::....::...:|.::..|:|.         :..|.:...:.|.|::|..
  Rat    78 QKTCHRAPQEALPTTSAATSLLGQEVVPTAA---------EEGPEEPITVAHIVVEATS------ 127

  Fly   147 DTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGK----- 206
                             ||:|....|..:.:.:.:|::|..:    .|.||.:..::.|.
  Rat   128 -----------------LAEDMSHAPDLVGSGHIKEVIVAAE----AEPGDGEMAEAPGSPNHQE 171

  Fly   207 ----GNSSQTKIKEIV----EHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIE 263
                |...|.::|.:|    .:||..|:|||:....||.|:
  Rat   172 LGLIGEGEQAQVKLLVNKEGRYVCMLCHKTFKTGSILKAHM------------------------ 212

  Fly   264 KDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANL 328
                                                           :|||...|..|.:|.|:.
  Rat   213 -----------------------------------------------VTHSSRKDHECKLCGASF 230

  Fly   329 RSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQK-YSSC-------------------- 372
            |::..|..|..:|... :||.|..|||.|..|..|.||.| .:.|
  Rat   231 RTKGSLIRHHRRHTDE-RPYKCAKCGKSFRESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVP 294

  Fly   373 ---SSNETDTMSCKVCDR------VFYRLDNLRSHLKQHLGTQVVKKP--------------EYM 414
               |::...|::..|...      |.:.:.:.:..:...:..|:.:.|              |..
  Rat   295 AGSSASTVGTVTSSVAGEPMETSPVIHLVTDAKGTVIHEVHVQMQELPLGMKALTPESADCEELP 359

  Fly   415 C---HTCKNCFYSL---------------STL------------------------------NIH 431
            |   ::.:|..:..               |||                              .:.
  Rat   360 CSRENSRENLLHQAMQNSGIVLDRVAGEESTLQPAPPSGSSPQSLGDGPSELPLLEVEQIETQVA 424

  Fly   432 IRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERP 496
            ....|..:...|..|.:.|.:...|:.|:|.|.|.:|::||.|.:||....:|.:|.:.|..||.
  Rat   425 SEAATVPRTHPCSQCSETFPSAATLEAHKRGHIGPRPFTCTQCGKAFPKAYLLKKHQEVHVHERR 489

  Fly   497 HKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECK 559
            .:|.:|||.:.....:|.|.:.|.  |||||.||.:::||:...:.|.:||...|..|  |..|.
  Rat   490 FRCGDCGKLYKTIAHVRGHRRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHV--CQFCS 552

  Fly   560 RNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHEC--D 622
            |.||....|..|:   :|...::...            |..|.:.|....||.||:||...|  :
  Rat   553 RGFREKGSLVRHV---RHHTGEKPFK------------CYKCGRGFAEHGTLNRHLRTKGGCLLE 602

  Fly   623 PDDIFGVEPHPSKRAKKDIESEEVVPVALN-------------------TSAGSLI----SSQTD 664
            .:::...|..||..|....|....|.|..:                   ||..:.|    .::.|
  Rat   603 VEELLVSEESPSAAATVLAEDPHTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVD 667

  Fly   665 GNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKK 729
            .:.:.|.:.:|.:. ||...|.::|.|              :..||.:..||...:. ::....:
  Rat   668 SHIMKVVQQIVHQA-GAGHQIIVQNVT--------------MDQEAALGSEAAAADT-ITIATPE 716

  Fly   730 EQRKSLAASLAAAIADNLEESC-----SEDDFSGEILTEEDIKLKENVGKLI 776
            ...:.:|.:||:||::....:.     |.:..:..:::.|||::.|:.|:|:
  Rat   717 SLTEQVAMTLASAISEGTVLTARAGPNSTEQATVTMVSSEDIEILEHGGELV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	0/20 (0%)
		COG5048	<312..517	CDD:227381	62/296 (21%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		zf-C2H2	348..368	CDD:278523	10/19 (53%)
		C2H2 Zn finger	350..368	CDD:275368	9/17 (53%)
		C2H2 Zn finger	382..402	CDD:275368	2/25 (8%)
		C2H2 Zn finger	415..435	CDD:275368	5/67 (7%)
		zf-H2C2_2	428..451	CDD:290200	4/52 (8%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	10/23 (43%)
		COG5048	<467..620	CDD:227381	49/154 (32%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	9/23 (39%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..572	CDD:275368	6/16 (38%)
		C2H2 Zn finger	598..615	CDD:275371	6/16 (38%)
E4f1	NP_001171975.1	COG5048	193..594	CDD:227381	101/489 (21%)
		C2H2 Zn finger	195..215	CDD:275368	8/90 (9%)
		zf-C2H2	221..243	CDD:278523	6/21 (29%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-H2C2_2	235..258	CDD:290200	9/23 (39%)
		C2H2 Zn finger	251..269	CDD:275368	9/17 (53%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		zf-H2C2_2	449..471	CDD:290200	9/21 (43%)
		zf-C2H2	462..484	CDD:278523	7/21 (33%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		zf-H2C2_2	504..529	CDD:290200	10/24 (42%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	548..568	CDD:275368	7/22 (32%)
		zf-H2C2_2	560..584	CDD:290200	5/38 (13%)
		C2H2 Zn finger	576..595	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100