DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and Zfp966

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001170878.1	Gene:	Zfp966 / 667962	MGIID:	3709288	Length:	485	Species:	Mus musculus

Alignment Length:	465	Identity:	138/465 - (29%)
Similarity:	207/465 - (44%)	Gaps:	77/465 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 EHVCGKCYKTFR------RVQSLKKHLEF--CRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDIC 275
            ||.....::|.|      |..|.::|.||  |.....|..|
Mouse    68 EHTIEDHFQTSRSHGRHERRSSAEQHSEFIPCGKAFAYQSR------------------------ 108

  Fly   276 FCCSESYDTFHLG--HINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHE 338
               |:.:...|.|  |..|..|.|.|.|::..:| :..||:....:.|:.........:.|.:|:
Mouse   109 ---SQRHVRIHNGEKHYECNQCGKDFGTRSVLQR-LKRTHTGEKPYECNHYGKAFAESSTLQIHK 169

  Fly   339 EQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHL 403
            .:|... |||.|..|.|.|.:...|:.|::..:...    ...||.|.:.|.:..:|..|.:.|.
Mouse   170 RKHTGE-KPYECNHCVKAFAKMSKLQIHKRIHTGEK----PYECKQCGKAFTQSSHLGIHKRTHT 229

  Fly   404 GTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKP 468
            |    :|| |.|..|...|...|||..|.:|||||||::|..|||.|.....|:.|:|.||||||
Mouse   230 G----EKP-YECKQCGKAFTRSSTLQTHKQTHTGEKPYECKQCDKAFVRRGELQIHKRTHTGEKP 289

  Fly   469 YSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEK 531
            |.|..|.:|||....|..|.:.||||:|::|.:|||:|..::.|:.|.:||.  :|:.|:|||:.
Mouse   290 YECKQCGKAFAQSGTLQIHKRTHTGEKPYECKQCGKAFAHSSTLQIHKRTHTGEKPYECKQCDKA 354

  Fly   532 FKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRS-------- 588
            |....:|:.|.:||:..|  .:.|.:|.:.|.....|:.|  |..|:.::.....:.
Mouse   355 FVKRGELQIHKQTHTGEK--PYECKQCGKAFAQSGTLQVH--ERTHTGEKPFECNQCGKAFVQCI 415

  Fly   589 AVKIMERT-------DCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEV 646
            |::|.|||       :|..|.|.|..|:||:.|.|| |.       |.:|:..|:..|.......
Mouse   416 ALRIHERTHTGEKPYECKQCGKAFAHSNTLQIHKRT-HT-------GEKPYECKQCGKAFAHSST 472

  Fly   647 VPVALNTSAG 656
            :.:...|..|
Mouse   473 LQIHKQTHTG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	74/204 (36%)
		C2H2 Zn finger	321..341	CDD:275368	3/19 (16%)
		zf-C2H2	348..368	CDD:278523	7/19 (37%)
		C2H2 Zn finger	350..368	CDD:275368	6/17 (35%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..451	CDD:290200	13/22 (59%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..479	CDD:290200	13/23 (57%)
		COG5048	<467..620	CDD:227381	57/169 (34%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	12/23 (52%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	7/16 (44%)
Zfp966	NP_001170878.1	KRAB	22..63	CDD:366587
		COG5048	94..478	CDD:227381	129/433 (30%)
		C2H2 Zn finger	99..116	CDD:275368	4/43 (9%)
		C2H2 Zn finger	124..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	3/19 (16%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	6/21 (29%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		C2H2 Zn finger	432..452	CDD:275368	10/20 (50%)
		C2H2 Zn finger	460..480	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100