DRSC/TRiP Functional Genomics Resources

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Protein Alignment su(Hw) and PRDM14

DIOPT Version :9

Sequence 1:NP_001247098.1 Gene:su(Hw) / 41740 FlyBaseID:FBgn0003567 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_078780.1 Gene:PRDM14 / 63978 HGNCID:14001 Length:571 Species:Homo sapiens


Alignment Length:280 Identity:81/280 - (28%)
Similarity:117/280 - (41%) Gaps:55/280 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 ESYDTFHLGH--------------INCPDCPKSFK-TQTSYERHIFI------------------ 311
            |.::..||.|              :||...||... .....:.|||.                  
Human   304 EIFEDGHLSHFIDGKGGTGNWMSYVNCARFPKEQNLVAVQCQGHIFYESCKEIHQNQELLVWYGD 368

  Fly   312 THSEFSDFPCSICNANLRSEALLALHEEQHKSRG------KPYACKICGKDFTRSYHLKRHQKYS 370
            .:.:|.|.|.|           |.:.|...:..|      :.|.|:.|||.||..|:..:|.||:
Human   369 CYEKFLDIPVS-----------LQVTEPGKQPSGPSEESAEGYRCERCGKVFTYKYYRDKHLKYT 422

  Fly   371 SCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTH 435
            .|.........|.:|.|.|.:.|.||.|:   |......:| :.|.||..||...|:||.|:|.|
Human   423 PCVDKGDRKFPCSLCKRSFEKRDRLRIHI---LHVHEKHRP-HKCSTCGKCFSQSSSLNKHMRVH 483

  Fly   436 TGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKR-HTGERPHKC 499
            :|::|:.|..|.|:|:|...|:.|.|.|:||||:.|..|.::||.....:.|::| |..:....|
Human   484 SGDRPYQCVYCTKRFTASSILRTHIRQHSGEKPFKCKYCGKSFASHAAHDSHVRRSHKEDDGCSC 548

  Fly   500 DECGKSFIQATQLRTHSKTH 519
            ..|||.|.......:|.|.|
Human   549 SICGKIFSDQETFYSHMKFH 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
su(Hw)NP_001247098.1 C2H2 Zn finger 292..313 CDD:275368 6/39 (15%)
COG5048 <312..517 CDD:227381 68/211 (32%)
C2H2 Zn finger 321..341 CDD:275368 3/19 (16%)
zf-C2H2 348..368 CDD:278523 9/19 (47%)
C2H2 Zn finger 350..368 CDD:275368 8/17 (47%)
C2H2 Zn finger 382..402 CDD:275368 8/19 (42%)
C2H2 Zn finger 415..435 CDD:275368 10/19 (53%)
zf-H2C2_2 428..451 CDD:290200 10/22 (45%)
C2H2 Zn finger 443..463 CDD:275368 8/19 (42%)
zf-H2C2_2 455..479 CDD:290200 10/23 (43%)
COG5048 <467..620 CDD:227381 17/54 (31%)
C2H2 Zn finger 471..491 CDD:275368 6/20 (30%)
zf-H2C2_2 484..508 CDD:290200 8/24 (33%)
C2H2 Zn finger 499..519 CDD:275368 7/19 (37%)
C2H2 Zn finger 525..545 CDD:275368
C2H2 Zn finger 555..572 CDD:275368
C2H2 Zn finger 598..615 CDD:275371
PRDM14NP_078780.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..191
Interaction with CBFA2T2. /evidence=ECO:0000250|UniProtKB:E9Q3T6 194..384 16/90 (18%)
SET 266..371 CDD:214614 11/66 (17%)
C2H2 Zn finger 402..426 CDD:275368 11/23 (48%)
C2H2 Zn finger 434..453 CDD:275368 8/21 (38%)
COG5048 <460..568 CDD:227381 41/108 (38%)
C2H2 Zn finger 463..483 CDD:275368 10/19 (53%)
C2H2 Zn finger 491..511 CDD:275368 8/19 (42%)
C2H2 Zn finger 519..537 CDD:275368 5/17 (29%)
C2H2 Zn finger 548..565 CDD:275371 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4835
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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