DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and PRDM15

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_011527985.1	Gene:	PRDM15 / 63977	HGNCID:	13999	Length:	1441	Species:	Homo sapiens

Alignment Length:	1007	Identity:	210/1007 - (20%)
Similarity:	370/1007 - (36%)	Gaps:	277/1007 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KDKRPATRMK--------------LLNDVGAGEDSEAS--TTTTTSRTPSNKQEKRGSVAGSRIK 72
            :|..|.|.::              :|...|:|..:..:  .:......||....|..|.....::
Human   446 RDIPPGTELRVWYAAFYAKKMDKPMLKQAGSGVHAAGTPENSAPVESEPSQWACKVCSATFLELQ 510

  Fly    73 ILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAV-ETTKIKTSPSKRKKMEHYVL 136
            :|||.:||..:..|.....|.:.||:..|   |:.||.....|| |:..:.|...|:|..
Human   511 LLNEHLLGHLEQAKSLPPGSQSEAAAPEK---EQDTPRGEPPAVPESENVATKEQKKKPR----- 567

  Fly   137 QAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTE--DDEDLGEDGDED 199
            :..|.:.:||:..:.:|.:::.|        |:|..           ::||  .||.:....||
Human   568 RGRKPKVSKAEQPLVIVEDKEPT--------EQVAE-----------IITEVPPDEPVSATPDE- 612

  Fly   200 GEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSG-YHLRKADMLKNLEKIE 263
                            .|:|.|.||...|.....|:.|   |..:.:. ..|:::.:|.:...|.
Human   613 ----------------RIMELVLGKLATTTTDTSSVPK---FTHHQNNTITLKRSLILSSRHGIR 658

  Fly   264 KDAV--VMEKKDI--CFCCSESY-DTFHLG-HI--------NCPDCPKSFKTQTSYERHIFITHS 314
            :..:  :.|.|.:  |..||:.: ::.:|. |:        .|.:|.|.|..:.|.::|:...||
Human   659 RKLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRSHGDKLFKCEECAKLFSRKESLKQHVSYKHS 723

  Fly   315 ------EFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCS 373
                  |:. :.|..|....|.|:.|..|  ..::..|.:.|::|.:.|:.:.:|.:|:|
Human   724 RNEVDGEYR-YRCGTCEKTFRIESALEFH--NCRTDDKTFQCEMCFRFFSTNSNLSKHKK----- 780

  Fly   374 SNETDTMSCKVCDRVFYRLDNLRSHLKQHL--------------GTQVV--KKPEYMCHTCKNCF 422
            .:.....:|:||.::|||.|.:..|.::||              |..:|  ||....|..|...|
Human   781 KHGDKKFACEVCSKMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGENLVRYKKEPSGCPVCGKVF 845

  Fly   423 YSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYH------------------------ 463
            ...|.:|.|:.|| |:|.:.|::|.:||..:..|:.|...|
Human   846 SCRSNMNKHLLTH-GDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSE 909

  Fly   464 ---------------------------------------TGEKPYSCTVCNQAFAVKEV------ 483
                                                   ..||.|.|::||:.||:|..
Human   910 ENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMV 974

  Fly   484 ------------------------------LNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKT 518
                                          |.||...|||.:.|.|::|||||.:...|:.|.:.
Human   975 IHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRV 1039

  Fly   519 H--IRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDE------- 574
            |  :|.:.|.:|.:..||:..|..|:|.|...|.  :.|.||.|.|.....:.:|...
Human  1040 HDNVREYLCAECGKGMKTKHALRHHMKLHKGIKE--YECKECHRRFAQKVNMLKHCKRHTGIKDF 1102

  Fly   575 -----GK-HSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHP 633
                 || .|.:....:.:....:.::..|::|||.:.:...|::|::..|:
Human  1103 MCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHD------------- 1154

  Fly   634 SKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLD 698
                |.:.:|.::....::|.|.  :|.........|....:|:.|...:|.|::..:..|:..:
Human  1155 ----KVEAQSCQLCGTKVSTRAS--MSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPE 1213

  Fly   699 GAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTE 763
            ..:|.|.|.       |.|..:|......:|::.:..|.:.....|...|.|..|.:|:|.: .:
Human  1214 LTLEQEDLA-------EGKHGKAAKRSHKRKQKPEEEAGAPVPEDATFSEYSEKETEFTGSV-GD 1270

  Fly   764 EDIKLKENVGKLIDMLVDPPIL---KKYGWPN---APEETVLCKVIEN-----CGHDLTKGGENY 817
            |.....:::.:::..|.||.:.   ...|..|   .|..|.......|     .||..|.  |..
Human  1271 ETNSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAATQFTNLQPVAVGHLTTP--ERQ 1333

  Fly   818 AELDYGSRMREYCKLLFTVVIHNDSIKSLLNN 849
            .:||         ..:.||.....|..::|:|
Human  1334 LQLD---------NSILTVTFDTVSGSAMLHN 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	71/325 (22%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		zf-C2H2	348..368	CDD:278523	5/19 (26%)
		C2H2 Zn finger	350..368	CDD:275368	5/17 (29%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	9/22 (41%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	9/86 (10%)
		COG5048	<467..620	CDD:227381	49/203 (24%)
		C2H2 Zn finger	471..491	CDD:275368	9/55 (16%)
		zf-H2C2_2	484..508	CDD:290200	13/23 (57%)
		C2H2 Zn finger	499..519	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	598..615	CDD:275371	5/16 (31%)
PRDM15	XP_011527985.1	SET	349..465	CDD:214614	3/18 (17%)
		GAGA_bind	<515..>580	CDD:283799	19/72 (26%)
		COG5048	663..1125	CDD:227381	104/472 (22%)
		zf-C2H2	672..694	CDD:278523	5/21 (24%)
		C2H2 Zn finger	674..694	CDD:275368	5/19 (26%)
		C2H2 Zn finger	701..722	CDD:275368	6/20 (30%)
		C2H2 Zn finger	735..751	CDD:275368	5/15 (33%)
		C2H2 Zn finger	789..809	CDD:275368	8/19 (42%)
		C2H2 Zn finger	838..858	CDD:275368	6/19 (32%)
		C2H2 Zn finger	865..885	CDD:275368	6/19 (32%)
		C2H2 Zn finger	928..949	CDD:275370	0/20 (0%)
		C2H2 Zn finger	956..976	CDD:275368	6/19 (32%)
		C2H2 Zn finger	992..1012	CDD:275368	3/19 (16%)
		zf-H2C2_2	1004..1029	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1020..1040	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1048..1068	CDD:275368	7/19 (37%)
		zf-H2C2_2	1060..1085	CDD:290200	10/26 (38%)
		C2H2 Zn finger	1076..1096	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1104..1124	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1132..1153	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910